IT1153356B - Amminoacidi fosfinilalcanoici utili come agenti ipotensivi - Google Patents

Amminoacidi fosfinilalcanoici utili come agenti ipotensivi

Info

Publication number
IT1153356B
IT1153356B IT24380/82A IT2438082A IT1153356B IT 1153356 B IT1153356 B IT 1153356B IT 24380/82 A IT24380/82 A IT 24380/82A IT 2438082 A IT2438082 A IT 2438082A IT 1153356 B IT1153356 B IT 1153356B
Authority
IT
Italy
Prior art keywords
phosphinylalcanoic
hypothensive
agents
amino acids
acids useful
Prior art date
Application number
IT24380/82A
Other languages
English (en)
Other versions
IT8224380A0 (it
IT8224380A1 (it
Inventor
Edward W Petrillo
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8224380A0 publication Critical patent/IT8224380A0/it
Publication of IT8224380A1 publication Critical patent/IT8224380A1/it
Application granted granted Critical
Publication of IT1153356B publication Critical patent/IT1153356B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT24380/82A 1981-11-23 1982-11-23 Amminoacidi fosfinilalcanoici utili come agenti ipotensivi IT1153356B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/323,859 US4396772A (en) 1981-11-23 1981-11-23 Phosphinylalkanoyl amino acids

Publications (3)

Publication Number Publication Date
IT8224380A0 IT8224380A0 (it) 1982-11-23
IT8224380A1 IT8224380A1 (it) 1984-05-23
IT1153356B true IT1153356B (it) 1987-01-14

Family

ID=23261036

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24380/82A IT1153356B (it) 1981-11-23 1982-11-23 Amminoacidi fosfinilalcanoici utili come agenti ipotensivi

Country Status (7)

Country Link
US (1) US4396772A (it)
JP (1) JPS5892684A (it)
CA (1) CA1185248A (it)
DE (1) DE3243057A1 (it)
FR (1) FR2516924B1 (it)
GB (1) GB2109793B (it)
IT (1) IT1153356B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
EP0075334A3 (en) * 1981-09-25 1984-03-21 The Wellcome Foundation Limited Pharmaceutical compounds, and preparation, formulations and use thereof
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4427665A (en) 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions
GR81744B (it) * 1983-01-28 1984-12-12 Schering Corp
US4873356A (en) * 1987-09-30 1989-10-10 E. R. Squibb & Sons, Inc. Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4179464A (en) * 1977-11-14 1979-12-18 Schultz Robert J Preparation of N-(phosphonoacetyl)-L-aspartic acid
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
US4168267A (en) * 1978-10-23 1979-09-18 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl prolines
US4371526A (en) * 1981-08-21 1983-02-01 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted 4,5-dihydropyrazole-5-carboxylic acid derivatives and hypotensive method and composition

Also Published As

Publication number Publication date
GB2109793B (en) 1985-09-04
US4396772A (en) 1983-08-02
IT8224380A0 (it) 1982-11-23
GB2109793A (en) 1983-06-08
FR2516924B1 (fr) 1985-05-31
JPS5892684A (ja) 1983-06-02
IT8224380A1 (it) 1984-05-23
FR2516924A1 (fr) 1983-05-27
DE3243057A1 (de) 1983-05-26
CA1185248A (en) 1985-04-09

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