EA200001140A1 - СОЕДИНЕНИЯ-ИНГИБИТОРЫ sPLA2 ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ - Google Patents

СОЕДИНЕНИЯ-ИНГИБИТОРЫ sPLA2 ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ

Info

Publication number
EA200001140A1
EA200001140A1 EA200001140A EA200001140A EA200001140A1 EA 200001140 A1 EA200001140 A1 EA 200001140A1 EA 200001140 A EA200001140 A EA 200001140A EA 200001140 A EA200001140 A EA 200001140A EA 200001140 A1 EA200001140 A1 EA 200001140A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disease
spla2
treatment
compounds inhibitors
inhibitors
Prior art date
Application number
EA200001140A
Other languages
English (en)
Inventor
Вилльям Луис Макиас
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200001140A1 publication Critical patent/EA200001140A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Раскрыт способ лечения воспалительной болезни кишечника путем введения человеку, нуждающемуся в этом, терапевтически эффективного количества ингибитора sPLA, такого как ингибитор sPLAна основе 1H-индол-3-глиоксиламида.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001140A 1998-05-01 1999-04-20 СОЕДИНЕНИЯ-ИНГИБИТОРЫ sPLA2 ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ EA200001140A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8387498P 1998-05-01 1998-05-01
PCT/US1999/008654 WO1999057100A1 (en) 1998-05-01 1999-04-20 Spla2 inhibitor compounds for treatment of disease

Publications (1)

Publication Number Publication Date
EA200001140A1 true EA200001140A1 (ru) 2001-04-23

Family

ID=22181224

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001140A EA200001140A1 (ru) 1998-05-01 1999-04-20 СОЕДИНЕНИЯ-ИНГИБИТОРЫ sPLA2 ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ

Country Status (20)

Country Link
US (1) US6340699B1 (ru)
EP (1) EP1084108A4 (ru)
JP (1) JP2002513783A (ru)
KR (1) KR20010043190A (ru)
CN (1) CN1299348A (ru)
AU (1) AU3656299A (ru)
BR (1) BR9910095A (ru)
CA (1) CA2330856A1 (ru)
CZ (1) CZ20004052A3 (ru)
EA (1) EA200001140A1 (ru)
HR (1) HRP20000739A2 (ru)
HU (1) HUP0102243A2 (ru)
ID (1) ID27153A (ru)
IL (1) IL139019A0 (ru)
NO (1) NO20005479L (ru)
PL (1) PL343708A1 (ru)
SK (1) SK16342000A3 (ru)
TR (1) TR200003194T2 (ru)
WO (1) WO1999057100A1 (ru)
ZA (1) ZA200005563B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
WO2001055108A2 (en) * 2000-01-25 2001-08-02 Eli Lilly And Company Use of spl a2 inhibitors for the treatment of inflammation
JPWO2002000621A1 (ja) 2000-06-29 2004-04-22 塩野義製薬株式会社 Ｘ型ｓＰＬＡ２阻害作用を有する化合物
AU2002224531B2 (en) * 2000-07-24 2005-08-25 Dow Global Technologies Inc. Thermoplastic superabsorbent polymer blend compositions and their preparation
CA2627353A1 (en) * 2005-11-03 2007-05-18 Ilypsa, Inc. Indole compounds having c4-acidic substituents and use thereof as phospholipase-a2 inhibitors
CA2720275A1 (en) * 2008-04-01 2009-10-08 Astellas Pharma Inc. Indolinone compound
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
US9290752B2 (en) 2013-03-13 2016-03-22 Sunny Delight Beverages Co. Process for enhancing the amylase inhibitory efficacy from phaseolus vulgaris extracts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356919A (en) 1991-05-30 1994-10-18 G. D. Searle & Co. Leukotriene B4 synthesis inhibitors
DE4218096A1 (de) 1992-06-02 1993-12-09 Boehringer Mannheim Gmbh Spiro-oxetane, Verfahren zu ihrer Herstellung und Arzneimittel
DE4323409A1 (de) 1993-07-13 1995-01-19 Boehringer Mannheim Gmbh Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel
CZ82295A3 (en) 1994-04-01 1995-12-13 Lilly Co Eli Derivative of 1h-indole-3-glyoxylamide and a pharmaceutical composition containing thereof
WO1995033462A1 (en) * 1994-06-02 1995-12-14 Smithkline Beecham Corporation Anti-inflammatory compounds
NZ298145A (en) * 1994-12-29 1998-08-26 Yamanouchi Pharma Co Ltd Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament
TR199900956T2 (xx) 1996-10-30 1999-07-21 Eli Lilly And Company S�bstit�e edilmi� trisiklik bile�imler.
EA003876B1 (ru) * 1998-02-25 2003-10-30 Дженетикс Инститьют, Ллс Ингибиторы фосфолипазных ферментов

Also Published As

Publication number Publication date
PL343708A1 (en) 2001-08-27
CZ20004052A3 (cs) 2002-05-15
BR9910095A (pt) 2000-12-26
WO1999057100A1 (en) 1999-11-11
SK16342000A3 (sk) 2002-04-04
EP1084108A4 (en) 2005-01-12
KR20010043190A (ko) 2001-05-25
AU3656299A (en) 1999-11-23
HUP0102243A2 (hu) 2001-10-28
NO20005479D0 (no) 2000-10-31
CA2330856A1 (en) 1999-11-11
EP1084108A1 (en) 2001-03-21
NO20005479L (no) 2000-12-20
ID27153A (id) 2001-03-08
TR200003194T2 (tr) 2001-03-21
ZA200005563B (en) 2002-01-10
HRP20000739A2 (en) 2001-10-31
IL139019A0 (en) 2001-11-25
US6340699B1 (en) 2002-01-22
CN1299348A (zh) 2001-06-13
JP2002513783A (ja) 2002-05-14

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