EA200100791A1 - Ингибиторы аминотрансфераз, зависимых от аминокислот с разветвленной цепью, и их применение в лечении диабетической ретинопатии - Google Patents

Ингибиторы аминотрансфераз, зависимых от аминокислот с разветвленной цепью, и их применение в лечении диабетической ретинопатии

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Publication number
EA200100791A1
EA200100791A1 EA200100791A EA200100791A EA200100791A1 EA 200100791 A1 EA200100791 A1 EA 200100791A1 EA 200100791 A EA200100791 A EA 200100791A EA 200100791 A EA200100791 A EA 200100791A EA 200100791 A1 EA200100791 A1 EA 200100791A1
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Eurasian Patent Office
Prior art keywords
diabetic retinopathy
amino acids
treatment
branched chain
formulas
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EA200100791A
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English (en)
Other versions
EA006597B1 (ru
Inventor
Джастин Стефен Брайнс
Лайн-Йен Ху
Сьюзан М. Хутсон
Катрин Фоли Ланоуэ
Эрих Лиет
Михаель Франсис Рафферти
Тодд Роберт Райдер
Ти-Жи Су
Девин Франклин Велти
Девид Юрген Вустроу
Original Assignee
Варнер-Ламберт Компани
Дзе Пенн Стейт Рисёрч Фаундейшн
Вэйк Форест Юнивёрсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Варнер-Ламберт Компани, Дзе Пенн Стейт Рисёрч Фаундейшн, Вэйк Форест Юнивёрсити filed Critical Варнер-Ламберт Компани
Publication of EA200100791A1 publication Critical patent/EA200100791A1/ru
Publication of EA006597B1 publication Critical patent/EA006597B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение представляет собой способ профилактики и терапевтического лечения диабетической ретинопатии. Способ включает назначение ингибитора формул I, II и III аминотрансфераз, зависимых от аминокислот с разветвленной цепью (BCAT) животным, таким как млекопитающие, в частности человек, в количестве, достаточном для лечения сетчатки при диабетической ретинопатии профилактически или терапевтически. Настоящее изобретение также представляет несколько новых ингибиторов ВСАТ формулы IV. В формулах I-IV n, m, X и R-Rимеют значения, данные в описании.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100791A 1999-12-08 2000-11-08 Ингибиторы аминотрансфераз, зависимых от аминокислот с разветвленной цепью, и их применение в лечении диабетической ретинопатии EA006597B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16963599P 1999-12-08 1999-12-08
US17539900P 2000-01-11 2000-01-11
US23002000P 2000-09-05 2000-09-05
PCT/US2000/030769 WO2001042191A1 (en) 1999-12-08 2000-11-08 Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy

Publications (2)

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EA200100791A1 true EA200100791A1 (ru) 2002-04-25
EA006597B1 EA006597B1 (ru) 2006-02-24

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EA200100791A EA006597B1 (ru) 1999-12-08 2000-11-08 Ингибиторы аминотрансфераз, зависимых от аминокислот с разветвленной цепью, и их применение в лечении диабетической ретинопатии

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EP (1) EP1157000B1 (ru)
JP (1) JP2003516379A (ru)
KR (1) KR20010101811A (ru)
CN (2) CN1626069A (ru)
AP (1) AP2001002242A0 (ru)
AR (1) AR037738A1 (ru)
AT (1) ATE308510T1 (ru)
AU (1) AU784553B2 (ru)
BG (1) BG105875A (ru)
BR (1) BR0008443A (ru)
CA (1) CA2361647A1 (ru)
CO (1) CO5280055A1 (ru)
CZ (1) CZ20012758A3 (ru)
DE (1) DE60023657T2 (ru)
DZ (1) DZ3141A1 (ru)
EA (1) EA006597B1 (ru)
EE (1) EE200100416A (ru)
ES (1) ES2252075T3 (ru)
GE (1) GEP20043298B (ru)
HK (1) HK1044933B (ru)
HR (1) HRP20010581A2 (ru)
HU (1) HUP0200570A3 (ru)
IS (1) IS6033A (ru)
MA (1) MA26777A1 (ru)
MX (1) MXPA01008085A (ru)
NO (1) NO20013844L (ru)
OA (1) OA11759A (ru)
PE (1) PE20010929A1 (ru)
PL (1) PL349193A1 (ru)
SK (1) SK11022001A3 (ru)
UY (1) UY26474A1 (ru)
WO (1) WO2001042191A1 (ru)
YU (1) YU57401A (ru)

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IL159299A0 (en) * 2001-06-11 2004-06-01 Xenoport Inc Orally administered dosage forms of gaba analog prodrugs having reduced toxicity
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
MXPA02010430A (es) * 2001-11-27 2003-06-02 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
MXPA02010231A (es) * 2001-11-27 2004-12-13 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
US20040058313A1 (en) * 2002-04-24 2004-03-25 Abreu Marcio Marc Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
ES2295751T3 (es) * 2004-09-20 2008-04-16 Kao Corporation Procedimiento para preparar lactonas y uso de las mismas como material odorifero.
US8795725B2 (en) 2004-11-04 2014-08-05 Xenoport, Inc. GABA analog prodrug sustained release oral dosage forms
US8828665B2 (en) 2007-02-16 2014-09-09 Ark Diagnostics, Inc. Compounds and methods for use in detecting gabapentin
WO2008155619A2 (en) * 2007-06-21 2008-12-24 Pfizer Inc. Preparation of optically-active cyclic amino acids
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2481801A1 (en) * 2011-01-28 2012-08-01 Deutsches Krebsforschungszentrum Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia
US10941109B2 (en) 2011-06-13 2021-03-09 Ergon Pharmaceuticals Llc Compositions and methods of treatment using a BCAT1 inhibitor
US9422224B2 (en) * 2011-06-13 2016-08-23 Ergon Pharmaceuticals Llc Methods of treatment using a BCAT1 inhibitor
CN113694202B (zh) * 2020-06-29 2023-03-31 江苏省中医院 Ass1或bckdk抑制剂在制备治疗溃疡性结肠炎的药物中的应用

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CZ293759B6 (cs) * 1996-03-14 2004-07-14 Warner-Lambert Company Substituovaná cyklická aminokyselina, její použití a farmaceutický prostředek na její bázi

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OA11759A (en) 2005-07-19
CN1170811C (zh) 2004-10-13
NO20013844D0 (no) 2001-08-07
YU57401A (sh) 2004-05-12
NO20013844L (no) 2001-10-04
AU784553B2 (en) 2006-05-04
DZ3141A1 (fr) 2001-01-14
AR037738A1 (es) 2004-12-01
EP1157000B1 (en) 2005-11-02
EP1157000A1 (en) 2001-11-28
CN1626069A (zh) 2005-06-15
KR20010101811A (ko) 2001-11-14
HK1044933A1 (en) 2002-11-08
JP2003516379A (ja) 2003-05-13
DE60023657T2 (de) 2006-07-20
HRP20010581A2 (en) 2002-08-31
WO2001042191A1 (en) 2001-06-14
ES2252075T3 (es) 2006-05-16
BG105875A (en) 2002-05-31
IS6033A (is) 2001-07-31
EA006597B1 (ru) 2006-02-24
CO5280055A1 (es) 2003-05-30
GEP20043298B (en) 2004-03-10
PE20010929A1 (es) 2001-09-08
AU1477901A (en) 2001-06-18
EE200100416A (et) 2002-12-16
ATE308510T1 (de) 2005-11-15
AP2001002242A0 (en) 2001-09-30
BR0008443A (pt) 2001-10-30
CA2361647A1 (en) 2001-06-14
HK1044933B (zh) 2005-06-03
MXPA01008085A (es) 2002-04-24
HUP0200570A3 (en) 2003-02-28
DE60023657D1 (de) 2005-12-08
HUP0200570A2 (en) 2002-06-29
MA26777A1 (fr) 2004-12-20
CZ20012758A3 (cs) 2002-09-11
SK11022001A3 (sk) 2002-11-06
PL349193A1 (en) 2002-07-01
CN1344245A (zh) 2002-04-10
UY26474A1 (es) 2001-01-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU