AR037738A1 - Inhibidores de aminotransferasa dependiente de aminoacidos de cadena ramificada y su uso en el tratamiento de la retinopatia diabetica - Google Patents

Inhibidores de aminotransferasa dependiente de aminoacidos de cadena ramificada y su uso en el tratamiento de la retinopatia diabetica

Info

Publication number
AR037738A1
AR037738A1 ARP000106493A ARP000106493A AR037738A1 AR 037738 A1 AR037738 A1 AR 037738A1 AR P000106493 A ARP000106493 A AR P000106493A AR P000106493 A ARP000106493 A AR P000106493A AR 037738 A1 AR037738 A1 AR 037738A1
Authority
AR
Argentina
Prior art keywords
hydrogen
inhibitors
dependent
aminotranspherase
treatment
Prior art date
Application number
ARP000106493A
Other languages
English (en)
Inventor
Justin Stephen Bryans
Lainyen Hu
Susan M Hutson
Kathryn Foley Lanoue
Erich Lieth
Michael Francis Rafferty
Todd Robert Ryder
Ti-Zhi Su
Devin Franklin Welty
David Juergen Wustrow
Original Assignee
Warner Lambert Co
Penn State Res Found
Univ Wake Forest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Penn State Res Found, Univ Wake Forest filed Critical Warner Lambert Co
Publication of AR037738A1 publication Critical patent/AR037738A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de la fórmula (1), en donde: R1 a R4 son hidrógeno o alquilo; X es NR5 u O; R5 es hidrógeno o alquilo; R6 es hidrógeno, alquilo, bencilo, alcanoilo, alcoxialcanoilo, arilalquilo, alcoxi, cicloalquilo, alilo, alquilcicloalquilo, halogenoalquilo trisustituido y en donde R1 a R4 son cada uno hidrógeno, entonces R6 no es hidrógeno o metilo; o una sal, éster, prodroga o amida farmacéuticamente aceptable de él. Cuando hay más de un estereoisómero, cada centro quiral puede ser independientemente R ó S. Como inhibidores de la aminotransferasa dependiente de aminoácidos de cadena ramificada.
ARP000106493A 1999-12-08 2000-12-07 Inhibidores de aminotransferasa dependiente de aminoacidos de cadena ramificada y su uso en el tratamiento de la retinopatia diabetica AR037738A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16963599P 1999-12-08 1999-12-08
US17539900P 2000-01-11 2000-01-11
US23002000P 2000-09-05 2000-09-05

Publications (1)

Publication Number Publication Date
AR037738A1 true AR037738A1 (es) 2004-12-01

Family

ID=27389690

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106493A AR037738A1 (es) 1999-12-08 2000-12-07 Inhibidores de aminotransferasa dependiente de aminoacidos de cadena ramificada y su uso en el tratamiento de la retinopatia diabetica

Country Status (33)

Country Link
EP (1) EP1157000B1 (es)
JP (1) JP2003516379A (es)
KR (1) KR20010101811A (es)
CN (2) CN1626069A (es)
AP (1) AP2001002242A0 (es)
AR (1) AR037738A1 (es)
AT (1) ATE308510T1 (es)
AU (1) AU784553B2 (es)
BG (1) BG105875A (es)
BR (1) BR0008443A (es)
CA (1) CA2361647A1 (es)
CO (1) CO5280055A1 (es)
CZ (1) CZ20012758A3 (es)
DE (1) DE60023657T2 (es)
DZ (1) DZ3141A1 (es)
EA (1) EA006597B1 (es)
EE (1) EE200100416A (es)
ES (1) ES2252075T3 (es)
GE (1) GEP20043298B (es)
HK (1) HK1044933B (es)
HR (1) HRP20010581A2 (es)
HU (1) HUP0200570A3 (es)
IS (1) IS6033A (es)
MA (1) MA26777A1 (es)
MX (1) MXPA01008085A (es)
NO (1) NO20013844L (es)
OA (1) OA11759A (es)
PE (1) PE20010929A1 (es)
PL (1) PL349193A1 (es)
SK (1) SK11022001A3 (es)
UY (1) UY26474A1 (es)
WO (1) WO2001042191A1 (es)
YU (1) YU57401A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
AU2002310409C1 (en) * 2001-06-11 2008-04-17 Xenoport, Inc. Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
MXPA02010231A (es) * 2001-11-27 2004-12-13 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
MXPA02010430A (es) * 2001-11-27 2003-06-02 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
US20040058313A1 (en) * 2002-04-24 2004-03-25 Abreu Marcio Marc Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
DE602004010135T2 (de) * 2004-09-20 2008-09-04 Kao Corp. Verfahren zur Herstellung von Lactonen und deren Verwendung als Geruchsstoffe
EP1811986B1 (en) 2004-11-04 2014-03-26 XenoPort, Inc. Gabapentin prodrug sustained release oral dosage forms
WO2008103319A2 (en) * 2007-02-16 2008-08-28 Ark Diagnostics, Inc. Compounds and methods for use in detecting gabapentin
WO2008155619A2 (en) * 2007-06-21 2008-12-24 Pfizer Inc. Preparation of optically-active cyclic amino acids
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2481801A1 (en) 2011-01-28 2012-08-01 Deutsches Krebsforschungszentrum Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia
US10941109B2 (en) 2011-06-13 2021-03-09 Ergon Pharmaceuticals Llc Compositions and methods of treatment using a BCAT1 inhibitor
JP6053768B2 (ja) * 2011-06-13 2016-12-27 エルゴン ファーマシューティカルズ エルエルシー Ｂｃａｔ１阻害剤を使用する治療方法
CN113694202B (zh) * 2020-06-29 2023-03-31 江苏省中医院 Ass1或bckdk抑制剂在制备治疗溃疡性结肠炎的药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2167717T3 (es) * 1996-03-14 2002-05-16 Warner Lambert Co Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos.

Also Published As

Publication number Publication date
WO2001042191A1 (en) 2001-06-14
AU784553B2 (en) 2006-05-04
SK11022001A3 (sk) 2002-11-06
ES2252075T3 (es) 2006-05-16
CN1344245A (zh) 2002-04-10
DE60023657D1 (de) 2005-12-08
BR0008443A (pt) 2001-10-30
EE200100416A (et) 2002-12-16
UY26474A1 (es) 2001-01-31
ATE308510T1 (de) 2005-11-15
BG105875A (en) 2002-05-31
DZ3141A1 (fr) 2001-01-14
CA2361647A1 (en) 2001-06-14
CN1626069A (zh) 2005-06-15
CO5280055A1 (es) 2003-05-30
CZ20012758A3 (cs) 2002-09-11
JP2003516379A (ja) 2003-05-13
PL349193A1 (en) 2002-07-01
HUP0200570A3 (en) 2003-02-28
HK1044933B (zh) 2005-06-03
EA200100791A1 (ru) 2002-04-25
NO20013844D0 (no) 2001-08-07
EP1157000B1 (en) 2005-11-02
GEP20043298B (en) 2004-03-10
EA006597B1 (ru) 2006-02-24
CN1170811C (zh) 2004-10-13
DE60023657T2 (de) 2006-07-20
YU57401A (sh) 2004-05-12
MA26777A1 (fr) 2004-12-20
HUP0200570A2 (en) 2002-06-29
HK1044933A1 (en) 2002-11-08
MXPA01008085A (es) 2002-04-24
OA11759A (en) 2005-07-19
EP1157000A1 (en) 2001-11-28
PE20010929A1 (es) 2001-09-08
HRP20010581A2 (en) 2002-08-31
AU1477901A (en) 2001-06-18
AP2001002242A0 (en) 2001-09-30
IS6033A (is) 2001-07-31
KR20010101811A (ko) 2001-11-14
NO20013844L (no) 2001-10-04

Similar Documents

Publication Publication Date Title
AR037738A1 (es) Inhibidores de aminotransferasa dependiente de aminoacidos de cadena ramificada y su uso en el tratamiento de la retinopatia diabetica
MXPA03011981A (es) 3-fluoruro-pirrolidinas como agentes antidiabeticos.
DK1280797T3 (da) Dipeptidylpeptidase IV-inhibitorer
PE20020509A1 (es) Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih
MX9606709A (es) Inhibidores de metaloproteasas de matriz.
PE20020585A1 (es) Inhibidores de metaloproteinasa del tipo pirimidin-2,4,6-triona
KR900018098A (ko) 피리돈 카르복실산과 항균제
NZ512864A (en) Triazole compounds with dopamine-D3-receptor affinity
PE20010482A1 (es) Derivados de 3-ureido-pirazol y procedimiento para su preparacion
MY105618A (en) N-phenylalkyl substitutes alpha-amino carboxamide derivatives and process for their preparation.
DK0738262T3 (da) Hidtil ukendte heterocykliske forbindelser
CO5611143A2 (es) Profarmacos de fosfatos de fluorooxindoles
PE20020500A1 (es) Derivados de piperidina, tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas
PE20000345A1 (es) Inhibidores enzimaticos
MY129473A (en) 3,3-diarylpropylamines, their use and preparation
ZA953981B (en) New azolidinediones as antihyperglycemic agents
PE20010931A1 (es) Oxazolidinonas que tienen la funcion de una sulfoximina
PE69099A1 (es) Inhibidores de proteasas
CA2321188A1 (en) Derivatives of azetidine and pyrrolidine
ES8403453A1 (es) Un procedimiento para preparar amidas del acido 1-metil-5-p-toluoilpirrol-2-acetico.
PE20020294A1 (es) Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina
UY24425A1 (es) Derivados de tiol con actividad inhibidora de metalopeptidasa.
ES8601165A1 (es) Procedimiento para la preparacion de derivados de acilamida.
MY111474A (en) Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders.
NZ332030A (en) Sulfonamide substituted chromans, processes for their preparation, their use as a medicament and pharmaceutical preparations comprising them

Legal Events

Date Code Title Description
FA Abandonment or withdrawal