PE20010931A1 - Oxazolidinonas que tienen la funcion de una sulfoximina - Google Patents
Oxazolidinonas que tienen la funcion de una sulfoximinaInfo
- Publication number
- PE20010931A1 PE20010931A1 PE2000001363A PE0013632000A PE20010931A1 PE 20010931 A1 PE20010931 A1 PE 20010931A1 PE 2000001363 A PE2000001363 A PE 2000001363A PE 0013632000 A PE0013632000 A PE 0013632000A PE 20010931 A1 PE20010931 A1 PE 20010931A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- oxazolidinones
- sulfoximine
- function
- thiazinan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A OXAZOLIDINONAS DE FORMULA I, DONDE A ES i, iii, iv, ENTRE OTROS; B ES a, b, c; W ES NHC(=X)R1, Y-HET; CUANDO A ES iv; W NO ES Y-HET; X ES O, S; CUANDO X ES O; B NO ES b; Y ES NH, O, S; Z ES S(=O)(=NR5); R1 ES ALQUILO C1-C4, CICLOALQUILO C3-C6(CH2)p OPCIONALMENTE SUSTITUIDO CON F, Cl, CN; R2 Y R3 SON H, F, Cl, ALQUILO; R4 ES H, CH3, F; R5 ES ALQUILO C1-C5, CO-ALQUILO C1-C4, ENTRE OTROS; p ES 0-2; n ES 2-3; j ES 1-5; SON COMPUESTOS PREFERIDOS N-({(5S)-3-[3-FLUORO-4-(1-IMINO-1-OXIDO-1 4,TIAZINAN-4-IL)FENIL]-2-OXO-1,3-OXAZOLIDIN-5-IL)METIL)ETANOTIOAMIDA, N-({(5S)-3-[3-FLUORO-4-(1-IMINO-1-OXIDO-1 4,4-TIAZINAN-4-IL)FENIL]-2-OXO-1,3-OXAZOLIDIN-5-IL)METIL)PROPANOTIOAMIDA, ENTRE OTROS. EL COMPUESTO I PUEDE SER UTIL COMO ANTIBIOTICO EN INFECCIONES OCULARES, CUTANEAS; UTILIZANDOSE DE 0,1 mg/Kg DE PESO/DIA A 100 mg/Kg DE PESO/DIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17191699P | 1999-12-21 | 1999-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010931A1 true PE20010931A1 (es) | 2001-08-29 |
Family
ID=22625632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000001363A PE20010931A1 (es) | 1999-12-21 | 2000-12-19 | Oxazolidinonas que tienen la funcion de una sulfoximina |
Country Status (22)
Country | Link |
---|---|
US (1) | US20010046987A1 (es) |
EP (1) | EP1242417A1 (es) |
JP (1) | JP2003518117A (es) |
KR (1) | KR20020067557A (es) |
CN (1) | CN1221548C (es) |
AR (1) | AR029211A1 (es) |
AU (1) | AU782078B2 (es) |
BR (1) | BR0016605A (es) |
CA (1) | CA2389482A1 (es) |
CO (1) | CO5251427A1 (es) |
CZ (1) | CZ20022142A3 (es) |
EA (1) | EA005567B1 (es) |
HU (1) | HUP0203869A2 (es) |
IL (1) | IL150348A0 (es) |
MX (1) | MXPA02006233A (es) |
NO (1) | NO20022973L (es) |
NZ (1) | NZ519725A (es) |
PE (1) | PE20010931A1 (es) |
PL (1) | PL356478A1 (es) |
SK (1) | SK7572002A3 (es) |
WO (1) | WO2001046185A1 (es) |
ZA (1) | ZA200204166B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
GB0108793D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0108764D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0108794D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
ES2268011T3 (es) * | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
BRPI0409217A (pt) | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
US7265140B2 (en) * | 2003-09-23 | 2007-09-04 | Pfizer Inc | Acyloxymethylcarbamate prodrugs of oxazolidinones |
DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
WO2006056877A2 (en) * | 2004-11-29 | 2006-06-01 | Pharmacia & Upjohn Company Llc | Diazepine oxazolidinones as antibacterial agents |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
ES2335307T3 (es) | 2005-06-29 | 2010-03-24 | PHARMACIA & UPJOHN COMPANY LLC | Homomorfolin oxalidinonas como agentes antibacterianos. |
DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
EP1934208B1 (de) | 2005-10-04 | 2011-03-23 | Bayer Schering Pharma Aktiengesellschaft | Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid |
DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
DE102007028319A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
WO2021184339A1 (en) * | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
ATE233766T1 (de) * | 1994-11-15 | 2003-03-15 | Upjohn Co | Antibakterielle bizyklische oxazin und thiazin- oxazolidinone |
ATE207487T1 (de) * | 1995-09-01 | 2001-11-15 | Upjohn Co | Phenyloxazolidinone mit einer c-c-bindung zu 4-8 gliedrigen heterocyclen |
ATE293609T1 (de) * | 1997-05-30 | 2005-05-15 | Upjohn Co | Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität |
-
2000
- 2000-12-12 JP JP2001547095A patent/JP2003518117A/ja active Pending
- 2000-12-12 PL PL00356478A patent/PL356478A1/xx not_active Application Discontinuation
- 2000-12-12 BR BR0016605-7A patent/BR0016605A/pt not_active IP Right Cessation
- 2000-12-12 SK SK757-2002A patent/SK7572002A3/sk unknown
- 2000-12-12 CZ CZ20022142A patent/CZ20022142A3/cs unknown
- 2000-12-12 HU HU0203869A patent/HUP0203869A2/hu unknown
- 2000-12-12 KR KR1020027007958A patent/KR20020067557A/ko not_active Application Discontinuation
- 2000-12-12 WO PCT/US2000/032451 patent/WO2001046185A1/en not_active Application Discontinuation
- 2000-12-12 IL IL15034800A patent/IL150348A0/xx unknown
- 2000-12-12 CA CA002389482A patent/CA2389482A1/en not_active Abandoned
- 2000-12-12 NZ NZ519725A patent/NZ519725A/en unknown
- 2000-12-12 EP EP00983792A patent/EP1242417A1/en not_active Withdrawn
- 2000-12-12 EA EA200200699A patent/EA005567B1/ru not_active IP Right Cessation
- 2000-12-12 CN CNB008160449A patent/CN1221548C/zh not_active Expired - Fee Related
- 2000-12-12 AU AU20502/01A patent/AU782078B2/en not_active Ceased
- 2000-12-12 MX MXPA02006233A patent/MXPA02006233A/es unknown
- 2000-12-14 US US09/736,858 patent/US20010046987A1/en not_active Abandoned
- 2000-12-19 PE PE2000001363A patent/PE20010931A1/es not_active Application Discontinuation
- 2000-12-20 CO CO00096639A patent/CO5251427A1/es not_active Application Discontinuation
- 2000-12-20 AR ARP000106795A patent/AR029211A1/es unknown
-
2002
- 2002-05-24 ZA ZA200204166A patent/ZA200204166B/xx unknown
- 2002-06-20 NO NO20022973A patent/NO20022973L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2389482A1 (en) | 2001-06-28 |
MXPA02006233A (es) | 2002-12-05 |
HUP0203869A2 (hu) | 2003-07-28 |
WO2001046185A1 (en) | 2001-06-28 |
JP2003518117A (ja) | 2003-06-03 |
AU782078B2 (en) | 2005-06-30 |
SK7572002A3 (en) | 2002-12-03 |
NO20022973D0 (no) | 2002-06-20 |
EA200200699A1 (ru) | 2003-02-27 |
US20010046987A1 (en) | 2001-11-29 |
CN1221548C (zh) | 2005-10-05 |
ZA200204166B (en) | 2003-10-29 |
CN1391572A (zh) | 2003-01-15 |
BR0016605A (pt) | 2003-02-25 |
AR029211A1 (es) | 2003-06-18 |
NZ519725A (en) | 2004-05-28 |
PL356478A1 (en) | 2004-06-28 |
KR20020067557A (ko) | 2002-08-22 |
EA005567B1 (ru) | 2005-04-28 |
IL150348A0 (en) | 2002-12-01 |
EP1242417A1 (en) | 2002-09-25 |
CO5251427A1 (es) | 2003-02-28 |
NO20022973L (no) | 2002-08-20 |
AU2050201A (en) | 2001-07-03 |
CZ20022142A3 (cs) | 2002-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |