PE20060619A1 - Derivados de oxazolidinona como antibacterianos - Google Patents

Derivados de oxazolidinona como antibacterianos

Info

Publication number
PE20060619A1
PE20060619A1 PE2005000792A PE2005000792A PE20060619A1 PE 20060619 A1 PE20060619 A1 PE 20060619A1 PE 2005000792 A PE2005000792 A PE 2005000792A PE 2005000792 A PE2005000792 A PE 2005000792A PE 20060619 A1 PE20060619 A1 PE 20060619A1
Authority
PE
Peru
Prior art keywords
alkyl
thioamide
oxazolidinyl
furan
oxo
Prior art date
Application number
PE2005000792A
Other languages
English (en)
Inventor
Biosca Montserrat Cano
Albert Palomer Benet
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of PE20060619A1 publication Critical patent/PE20060619A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

REFERIDA A UN COMPUESTO DE OXAZOLIDINONA DE FORMULA I, DONDE R1, R2, R3 Y R4 SON H, F Y Cl; A ES UN RADICAL SELECCIONADO DE (i), (ii), (iii) Y (iv); R5 Y R6 SON H, F, Br, CN, ENTRE OTROS; R7 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R8 Y R9 SON H, CN, CLQUILO C1-C6, ENTRE OTROS; R10 ES H, ALQUILO C1-C6, COR13, ENTRE OTROS; n ES 0 O 1; R13 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[[(5S)-3-[3-FLUORO-4-MORFOLIN-4-IL-FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]FURAN-3-IL-TIOAMIDA, N-[[(5S)-3-[3-FLUORO-4-(4'-TIOACETIL-4-PIPERAZINIL)-FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]FURAN-3-IL-TIOAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ACTIVOS CONTRA BACTERIAS GRAMPOSITIVAS Y GRAMNEGATIVAS, CON UNA DEBIL ACTIVIDAD INHIBITORIA DE LA MONOAMINOOXIDASA (MAO) Y SON UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS
PE2005000792A 2004-07-29 2005-07-07 Derivados de oxazolidinona como antibacterianos PE20060619A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04103657 2004-07-29

Publications (1)

Publication Number Publication Date
PE20060619A1 true PE20060619A1 (es) 2006-07-11

Family

ID=35355681

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000792A PE20060619A1 (es) 2004-07-29 2005-07-07 Derivados de oxazolidinona como antibacterianos

Country Status (17)

Country Link
US (1) US20090005369A1 (es)
EP (1) EP1786805A1 (es)
JP (1) JP2008508236A (es)
KR (1) KR20070048227A (es)
CN (1) CN101027296A (es)
AR (1) AR050426A1 (es)
AU (1) AU2005266318A1 (es)
BR (1) BRPI0512691A (es)
CA (1) CA2574668A1 (es)
MX (1) MX2007001065A (es)
NO (1) NO20070870L (es)
PA (1) PA8640401A1 (es)
PE (1) PE20060619A1 (es)
RU (1) RU2007107490A (es)
TW (1) TW200612923A (es)
UY (1) UY29012A1 (es)
WO (1) WO2006010756A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
EP2072513A1 (en) 2007-12-17 2009-06-24 Ferrer Internacional, S.A. A cyano piperidinyl-phenil-oxazolidinone and use thereof
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
CN103420995B (zh) * 2013-09-07 2015-07-01 吉首大学 噁唑烷酮-烷胺基-呋喃酮型化合物及其制法和用途
CN103420996B (zh) * 2013-09-07 2015-06-24 吉首大学 苯并吡喃酮-胺甲基-噁唑烷酮类化合物及其制法和用途
CN103483329B (zh) * 2013-09-07 2015-08-05 吉首大学 呋喃酮-芳基-噁唑烷酮型化合物及其制法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1252101A (es) * 1969-03-18 1971-11-03
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10105989A1 (de) * 2001-02-09 2002-08-14 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
CA2463794A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
TW200302095A (en) 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
RU2354372C2 (ru) * 2002-03-29 2009-05-10 Фармация Энд Апджон Компани Ллс Парентеральное, внутривенное и пероральное введение оксазолидинонов для лечения инфекционных поражений стопы при диабете
US20080214565A1 (en) * 2003-04-07 2008-09-04 Anita Mehta Oxazolidinone Derivatives as Antimicrobials

Also Published As

Publication number Publication date
KR20070048227A (ko) 2007-05-08
AR050426A1 (es) 2006-10-25
MX2007001065A (es) 2007-04-10
UY29012A1 (es) 2005-10-31
BRPI0512691A (pt) 2008-04-01
EP1786805A1 (en) 2007-05-23
RU2007107490A (ru) 2008-09-10
US20090005369A1 (en) 2009-01-01
CN101027296A (zh) 2007-08-29
WO2006010756A1 (en) 2006-02-02
AU2005266318A1 (en) 2006-02-02
TW200612923A (en) 2006-05-01
NO20070870L (no) 2007-04-16
CA2574668A1 (en) 2006-02-02
PA8640401A1 (es) 2006-03-24
JP2008508236A (ja) 2008-03-21

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