BRPI0411688A - antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados - Google Patents

antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados

Info

Publication number
BRPI0411688A
BRPI0411688A BRPI0411688-7A BRPI0411688A BRPI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A
Authority
BR
Brazil
Prior art keywords
derivatives
substituted oxazolidinone
group substituted
cyclopropyl group
antibiotics
Prior art date
Application number
BRPI0411688-7A
Other languages
English (en)
Inventor
Yasumichi Fukuda
Original Assignee
Merck & Co Inc
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Kyorin Seiyaku Kk filed Critical Merck & Co Inc
Publication of BRPI0411688A publication Critical patent/BRPI0411688A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

"ANTIBIóTICOS DE OXAZOLIDINONA SUBSTITUìDA DE GRUPO DE CICLOPROPIL E SEUS DERIVADOS". Esta invenção está relacionada a novas oxazolidinonas, que possuem metade de ciclopropil, que são eficazes contra patogêneses aeróbicas e anaeróbicas, como estafilococos, estreptococos e enterococos multi-resistentes espécie de Bacterióides spp., de Clostridia spp., bem como organismos de ácido rápido como Mycobacterium tuberculosis e outras espécies de micobactérias. Os compostos são representados pela fórmula estrutural (I) : seu enantiónero, diastereómero ou sal ou éster aceitável farmaceuticamente.
BRPI0411688-7A 2003-07-02 2004-06-29 antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados BRPI0411688A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
BRPI0411688A true BRPI0411688A (pt) 2006-12-26

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411688-7A BRPI0411688A (pt) 2003-07-02 2004-06-29 antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados

Country Status (23)

Country Link
US (2) US7462633B2 (pt)
EP (1) EP1646629B1 (pt)
JP (1) JP4607107B2 (pt)
KR (1) KR20060113625A (pt)
AR (1) AR044990A1 (pt)
AT (1) ATE471937T1 (pt)
AU (1) AU2004256083B2 (pt)
BR (1) BRPI0411688A (pt)
CA (1) CA2530140C (pt)
CL (1) CL2004001678A1 (pt)
DE (1) DE602004027811D1 (pt)
EC (1) ECSP056257A (pt)
IL (1) IL172785A0 (pt)
IS (1) IS8178A (pt)
MA (1) MA27938A1 (pt)
MX (1) MXPA06000228A (pt)
MY (1) MY140137A (pt)
NO (1) NO20060558L (pt)
NZ (1) NZ544237A (pt)
PE (1) PE20050732A1 (pt)
RU (1) RU2348628C2 (pt)
TW (1) TW200510421A (pt)
WO (1) WO2005005398A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027083A1 (en) * 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
US6969726B2 (en) * 2003-06-03 2005-11-29 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
EP1713785A1 (en) * 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
DE602006019870D1 (de) 2005-06-08 2011-03-10 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
US8030495B2 (en) * 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
NZ594408A (en) * 2009-02-03 2014-03-28 Trius Therapeutics Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
RU2012102094A (ru) 2009-06-26 2013-08-10 Панацеа Биотек Лтд. Новые азабициклогексаны
US9133116B2 (en) 2010-09-28 2015-09-15 Panacea Biotec Ltd. Bicyclic compounds
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053593A (en) * 1975-11-26 1977-10-11 Lew Frumoff Medical product combining antimicrobial, antiporasitic and vitamin complex
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
WO1994013649A1 (en) * 1992-12-08 1994-06-23 The Upjohn Company Tropone-substituted phenyloxazolidinone antibacterial agents
TW286317B (pt) 1993-12-13 1996-09-21 Hoffmann La Roche
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE69614847T2 (de) 1995-05-11 2002-04-04 Upjohn Co Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
WO2000070758A1 (fr) 1999-05-14 2000-11-23 Kabushiki Kaisha Toshiba Dispositif d'onde acoustique de surface
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
EP1263742B1 (en) 2000-02-10 2005-08-24 Pharmacia & Upjohn Company LLC Oxazolidinone thioamides with piperazine amide substituents
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
AU5889701A (en) * 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
JP2004504321A (ja) * 2000-07-17 2004-02-12 ランバクシー　ラボラトリーズ　リミテッド 抗微生物剤としてのオキサゾリジノン誘導体
WO2002027029A2 (en) * 2000-09-27 2002-04-04 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
US6689769B2 (en) 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
WO2003027083A1 (en) 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
EP1448536A1 (en) * 2001-11-29 2004-08-25 Merck & Co., Inc. Cyclopropyl-containing oxazolidinone antibiotics and derivatives thereof
CN1155585C (zh) 2001-12-19 2004-06-30 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
TW200302095A (en) 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
RU2004129276A (ru) 2002-02-28 2005-06-10 Астразенека Аб (Se) Производные 3-циклического-5-(азотсодержащего 5-членного кольцевого) метил-оксазолидинона и их применение в качестве антибактериальных средств
WO2003097059A1 (en) 2002-05-15 2003-11-27 Ranbaxy Laboratories Limited Polymorphic forms of phenyl oxazolidinone derivatives
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
EP1581524A2 (en) * 2002-11-28 2005-10-05 AstraZeneca AB Oxazolidinones as antibacterial agents
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
EP1615916A1 (en) * 2003-04-09 2006-01-18 Pharmacia & Upjohn Company LLC Antimicrobial 3.1.0 bicyclohexylphenyl-oxazolidinone derivatives and analogues
WO2004099199A1 (en) 2003-05-06 2004-11-18 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP2007521282A (ja) 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド オキサゾリジノン抗生物質およびその誘導体
WO2005005422A1 (en) 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
WO2005005420A1 (en) 2003-07-02 2005-01-20 Merck & Co., Inc. Cyclopropyl group substituted oyazolidinone antibiotics and derivatives thereof

Also Published As

Publication number Publication date
MA27938A1 (fr) 2006-06-01
PE20050732A1 (es) 2005-11-02
RU2005140379A (ru) 2007-08-10
DE602004027811D1 (de) 2010-08-05
US20050038092A1 (en) 2005-02-17
CL2004001678A1 (es) 2005-05-20
AU2004256083B2 (en) 2007-10-11
NZ544237A (en) 2008-09-26
KR20060113625A (ko) 2006-11-02
TW200510421A (en) 2005-03-16
WO2005005398A2 (en) 2005-01-20
AU2004256083A1 (en) 2005-01-20
MXPA06000228A (es) 2006-06-27
CA2530140C (en) 2010-11-09
NO20060558L (no) 2006-02-02
RU2348628C2 (ru) 2009-03-10
ECSP056257A (es) 2006-04-19
MY140137A (en) 2009-11-30
WO2005005398A3 (en) 2005-04-28
US20070203187A1 (en) 2007-08-30
IS8178A (is) 2005-12-13
JP2007521281A (ja) 2007-08-02
US7582659B2 (en) 2009-09-01
US7462633B2 (en) 2008-12-09
EP1646629A2 (en) 2006-04-19
IL172785A0 (en) 2006-06-11
ATE471937T1 (de) 2010-07-15
EP1646629B1 (en) 2010-06-23
CA2530140A1 (en) 2005-01-20
AR044990A1 (es) 2005-10-12
JP4607107B2 (ja) 2011-01-05

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: KYORIN PHARMACEUTICAL CO., LTD. (JP) , MERCK SHARP

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.