ATE471937T1 - Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon - Google Patents

Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Info

Publication number
ATE471937T1
ATE471937T1 AT04777196T AT04777196T ATE471937T1 AT E471937 T1 ATE471937 T1 AT E471937T1 AT 04777196 T AT04777196 T AT 04777196T AT 04777196 T AT04777196 T AT 04777196T AT E471937 T1 ATE471937 T1 AT E471937T1
Authority
AT
Austria
Prior art keywords
derivatives
group substituted
cyclopropyl group
substituted oxazolidinone
oxazolidinone antibiotics
Prior art date
Application number
AT04777196T
Other languages
English (en)
Inventor
Yasumichi Fukuda
Original Assignee
Merck Sharp & Dohme
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Kyorin Seiyaku Kk filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE471937T1 publication Critical patent/ATE471937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AT04777196T 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon ATE471937T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE471937T1 true ATE471937T1 (de) 2010-07-15

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04777196T ATE471937T1 (de) 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Country Status (23)

Country Link
US (2) US7462633B2 (de)
EP (1) EP1646629B1 (de)
JP (1) JP4607107B2 (de)
KR (1) KR20060113625A (de)
AR (1) AR044990A1 (de)
AT (1) ATE471937T1 (de)
AU (1) AU2004256083B2 (de)
BR (1) BRPI0411688A (de)
CA (1) CA2530140C (de)
CL (1) CL2004001678A1 (de)
DE (1) DE602004027811D1 (de)
EC (1) ECSP056257A (de)
IL (1) IL172785A0 (de)
IS (1) IS8178A (de)
MA (1) MA27938A1 (de)
MX (1) MXPA06000228A (de)
MY (1) MY140137A (de)
NO (1) NO20060558L (de)
NZ (1) NZ544237A (de)
PE (1) PE20050732A1 (de)
RU (1) RU2348628C2 (de)
TW (1) TW200510421A (de)
WO (1) WO2005005398A2 (de)

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ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
US8324398B2 (en) * 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
PL1656370T3 (pl) * 2003-06-03 2013-03-29 Melinta Subsidiary Corp Biarylowe związki heterocykliczne oraz sposoby ich wytwarzania i stosowania
EP1646630A1 (de) * 2003-07-02 2006-04-19 Merck & Co., Inc. Oxazolidinonantibiotika und derivate davon
RU2348628C2 (ru) 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
EP1713785A1 (de) * 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenierte heterocyclische biarylverbindungen und verfahren zu deren herstellung und verwendung
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
WO2006133397A2 (en) * 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
EP1912980A2 (de) * 2005-06-20 2008-04-23 Wockhardt Limited Oxazolidinone mit einer antimikrobiell wirkenden zusammensetzung und herstellungsverfahren
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
AU2008260647A1 (en) * 2007-05-23 2008-12-11 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
MX2011003820A (es) * 2008-10-10 2011-06-16 Trius Therapeutics Metodos para preparar oxazolidinonas y composiciones que las contienen.
MY156354A (en) 2009-02-03 2016-02-15 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2010150281A2 (en) 2009-06-26 2010-12-29 Panacea Biotec Ltd. Novel azabicyclohexanes
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

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US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
AU667198B2 (en) 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
RU2119484C1 (ru) * 1992-12-08 1998-09-27 Дзе Апджон Компани Тропонзамещенный фенилоксазолидинон или его фармацевтически приемлемые соли или гидраты
TW286317B (de) 1993-12-13 1996-09-21 Hoffmann La Roche
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE69614847T2 (de) 1995-05-11 2002-04-04 Upjohn Co Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
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WO2000070758A1 (fr) 1999-05-14 2000-11-23 Kabushiki Kaisha Toshiba Dispositif d'onde acoustique de surface
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RU2004136573A (ru) 2002-05-15 2005-08-10 Рэнбакси Лабораториз Лимитед (In) Производные фенилоксазолидинона
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RU2348628C2 (ru) * 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
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Also Published As

Publication number Publication date
AU2004256083B2 (en) 2007-10-11
ECSP056257A (es) 2006-04-19
CA2530140C (en) 2010-11-09
AR044990A1 (es) 2005-10-12
JP4607107B2 (ja) 2011-01-05
US7462633B2 (en) 2008-12-09
CA2530140A1 (en) 2005-01-20
MA27938A1 (fr) 2006-06-01
AU2004256083A1 (en) 2005-01-20
KR20060113625A (ko) 2006-11-02
EP1646629B1 (de) 2010-06-23
MXPA06000228A (es) 2006-06-27
US20050038092A1 (en) 2005-02-17
IL172785A0 (en) 2006-06-11
RU2348628C2 (ru) 2009-03-10
US20070203187A1 (en) 2007-08-30
NZ544237A (en) 2008-09-26
NO20060558L (no) 2006-02-02
IS8178A (is) 2005-12-13
WO2005005398A3 (en) 2005-04-28
EP1646629A2 (de) 2006-04-19
WO2005005398A2 (en) 2005-01-20
US7582659B2 (en) 2009-09-01
JP2007521281A (ja) 2007-08-02
TW200510421A (en) 2005-03-16
RU2005140379A (ru) 2007-08-10
BRPI0411688A (pt) 2006-12-26
PE20050732A1 (es) 2005-11-02
DE602004027811D1 (de) 2010-08-05
CL2004001678A1 (es) 2005-05-20
MY140137A (en) 2009-11-30

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties