PE20061490A1 - Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 - Google Patents
Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1Info
- Publication number
- PE20061490A1 PE20061490A1 PE2006000608A PE2006000608A PE20061490A1 PE 20061490 A1 PE20061490 A1 PE 20061490A1 PE 2006000608 A PE2006000608 A PE 2006000608A PE 2006000608 A PE2006000608 A PE 2006000608A PE 20061490 A1 PE20061490 A1 PE 20061490A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- optionally substituted
- alkyl
- inhibitors
- glycine transporter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/70—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/30—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES -(CH2)n-R1a, n ES 0-6, R1a ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO O OH, CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6), HALOGENO, ENTRE OTROS, -O-ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, ENTRE OTROS SUSTITUYENTES, ENTRE OTROS; R2 ES ALQUILO(C1-C8) OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, ENTRE OTROS, CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, ENTRE OTROS SUSTITUYENTES, ENTRE OTROS; R3 ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH, ENTRE OTROS, CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, ENTRE OTROS, (ALQUIL C1-C6)CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, ENTRE OTROS SUSTITUYENTES, ENTRE OTROS; R4 Y R5 SON H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO O OH, ENTRE OTROS; A ES O O -NR10- DONDE R10 ES H, BENCILO, FENILO, ENTRE OTROS; m ES 0 O 1. SON COMPUESTOS PREFERIDOS: 2,4-DICLORO-N-({1-CICLOPROPILMETIL-4-[(1-METIL-1H-1,2,3-TRIAZOL-4-IL)SULFONIL]CICLOHEXIL}METIL)BENZAMIDA, 2,4-DICLORO-N-(4-CICLOPROPILMETANOSULFONIL-1-CICLOPROPILMETILCICLOHEXILMETIL)BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL TRANSPORTADOR DE GLICINA (GlyT1) SIENDO UTILES PARA EL TRATAMIENTO DE ESQUIZOFRENIA
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0511452A GB0511452D0 (en) | 2005-06-06 | 2005-06-06 | Therapeutic agents |
GB0516787A GB0516787D0 (en) | 2005-08-17 | 2005-08-17 | Therapeutic agents |
GB0524968A GB0524968D0 (en) | 2005-12-08 | 2005-12-08 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061490A1 true PE20061490A1 (es) | 2007-02-09 |
Family
ID=36636407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000608A PE20061490A1 (es) | 2005-06-06 | 2006-06-05 | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 |
Country Status (10)
Country | Link |
---|---|
US (2) | US7626056B2 (es) |
EP (2) | EP1891002B1 (es) |
JP (1) | JP5281395B2 (es) |
AR (1) | AR057350A1 (es) |
AU (1) | AU2006256583B2 (es) |
CA (1) | CA2609969C (es) |
DO (1) | DOP2006000125A (es) |
PE (1) | PE20061490A1 (es) |
TW (1) | TW200716531A (es) |
WO (2) | WO2006131711A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007512251A (ja) * | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | 4−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
AU2005228133B2 (en) * | 2004-03-24 | 2011-09-08 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine glycine transporter inhibitors |
JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
US7576083B2 (en) * | 2004-05-05 | 2009-08-18 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
ATE488501T1 (de) * | 2004-09-30 | 2010-12-15 | Merck Sharp & Dohme | Cyclopropylpiperidinglycin-transporter-inhibito |
EP1831201B1 (en) * | 2004-12-21 | 2010-08-04 | Merck Sharp & Dohme Ltd. | Piperidine and azetidine derivatives as glyt1 inhibitors |
PE20061490A1 (es) | 2005-06-06 | 2007-02-09 | Merck Sharp & Dohme | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 |
US8163956B2 (en) | 2005-06-13 | 2012-04-24 | Merck Sharp & Dohme Corp. | Inhibitors of GLYT1 transporters |
GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
WO2009081789A1 (ja) * | 2007-12-26 | 2009-07-02 | Banyu Pharmaceutical Co., Ltd. | スルホニル置換六員環誘導体 |
CA2771710A1 (en) * | 2009-09-18 | 2011-03-24 | Zalicus Pharmaceuticals Ltd. | Aryl sulphone derivatives as calcium channel blockers |
US8937900B2 (en) | 2010-07-20 | 2015-01-20 | Qualcomm Incorporated | Enhancing pilot channel transmission in TD-SCDMA multicarrier systems using secondary carrier frequencies |
ES2963362T3 (es) * | 2010-07-20 | 2024-03-26 | Minerva Neurosciences Inc | Métodos de uso de derivados de amidas cíclicas para tratar la esquizofrenia y sus síntomas |
JPWO2014199960A1 (ja) * | 2013-06-10 | 2017-02-23 | 大正製薬株式会社 | グリシントランスポーター阻害物質 |
EP3134406A1 (en) | 2014-04-24 | 2017-03-01 | Dart Neuroscience (Cayman) Ltd | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors |
EP3215500A1 (en) | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Substituted azetidinyl compounds as glyt1 inhibitors |
UA122780C2 (uk) | 2014-12-02 | 2021-01-06 | Мінерва Ньюросаєнсиз, Інк. | Композиції, що містять 2-((1-(2-(4-фторфеніл)-2-оксоетил)піперидин-4-іл)метил)ізоіндолін-1-он, для лікування шизофренії |
CN106467477A (zh) * | 2016-08-26 | 2017-03-01 | 天津雅奥科技发展有限公司 | 一种合成化合物(1‑环丙基‑1‑氰基‑4‑环己酮)的新方法 |
CN106916089B (zh) * | 2017-03-14 | 2018-10-19 | 大连九信精细化工有限公司 | 一种选择性合成顺式4-正戊基环己硫醇的制备方法 |
UA127349C2 (uk) | 2017-06-21 | 2023-07-26 | Мінерва Ньюросаєнсиз, Інк. | Кишковорозчинна лікарська форма для перорального застосування з контрольованим вивільненням |
WO2020041504A1 (en) | 2018-08-21 | 2020-02-27 | Minerva Neurosciences, Inc. | Use of roluperidone to treat negative symptoms and disorders, increase neuroplasticity, and promote neuroprotection |
JP2023512000A (ja) | 2020-01-31 | 2023-03-23 | ソルヴェイ(ソシエテ アノニム) | ハロアルキル置換ピリジン化合物の製造のプロセス |
CN114426494B (zh) * | 2022-01-13 | 2023-09-15 | 江苏海洋大学 | 一种具有作用于taar激动剂的取代甲胺类衍生物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998024760A1 (en) * | 1996-12-03 | 1998-06-11 | Graybill Todd L | Aminobenzenedicarboxylic acid-based combinatorial libraries |
SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
KR20040066896A (ko) * | 2001-12-12 | 2004-07-27 | 에프. 호프만-라 로슈 아게 | 치환된 사이클로헥산 유도체 |
GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
FR2861073B1 (fr) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
JP2007512251A (ja) * | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | 4−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
AU2005228133B2 (en) * | 2004-03-24 | 2011-09-08 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine glycine transporter inhibitors |
JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
US7576083B2 (en) * | 2004-05-05 | 2009-08-18 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
ATE488501T1 (de) * | 2004-09-30 | 2010-12-15 | Merck Sharp & Dohme | Cyclopropylpiperidinglycin-transporter-inhibito |
EP1831201B1 (en) * | 2004-12-21 | 2010-08-04 | Merck Sharp & Dohme Ltd. | Piperidine and azetidine derivatives as glyt1 inhibitors |
PE20061490A1 (es) * | 2005-06-06 | 2007-02-09 | Merck Sharp & Dohme | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 |
-
2006
- 2006-06-05 PE PE2006000608A patent/PE20061490A1/es not_active Application Discontinuation
- 2006-06-05 DO DO2006000125A patent/DOP2006000125A/es unknown
- 2006-06-05 US US11/446,735 patent/US7626056B2/en active Active
- 2006-06-05 AR ARP060102342A patent/AR057350A1/es unknown
- 2006-06-05 AU AU2006256583A patent/AU2006256583B2/en not_active Ceased
- 2006-06-05 WO PCT/GB2006/002035 patent/WO2006131711A1/en active Application Filing
- 2006-06-05 WO PCT/GB2006/002052 patent/WO2006131713A1/en not_active Application Discontinuation
- 2006-06-05 CA CA2609969A patent/CA2609969C/en not_active Expired - Fee Related
- 2006-06-05 JP JP2008514201A patent/JP5281395B2/ja not_active Expired - Fee Related
- 2006-06-05 EP EP06744106A patent/EP1891002B1/en active Active
- 2006-06-05 TW TW095119888A patent/TW200716531A/zh unknown
- 2006-06-05 EP EP06744089A patent/EP1893566B1/en active Active
-
2009
- 2009-10-01 US US12/571,904 patent/US7851638B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2006256583B2 (en) | 2012-01-12 |
CA2609969A1 (en) | 2006-12-14 |
AR057350A1 (es) | 2007-11-28 |
US20100029726A1 (en) | 2010-02-04 |
EP1891002A1 (en) | 2008-02-27 |
CA2609969C (en) | 2015-10-27 |
US7626056B2 (en) | 2009-12-01 |
WO2006131713A1 (en) | 2006-12-14 |
EP1891002B1 (en) | 2012-05-30 |
EP1893566B1 (en) | 2013-02-13 |
JP2008542348A (ja) | 2008-11-27 |
AU2006256583A1 (en) | 2006-12-14 |
US20060276655A1 (en) | 2006-12-07 |
WO2006131711A1 (en) | 2006-12-14 |
TW200716531A (en) | 2007-05-01 |
DOP2006000125A (es) | 2006-12-31 |
JP5281395B2 (ja) | 2013-09-04 |
US7851638B2 (en) | 2010-12-14 |
EP1893566A1 (en) | 2008-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20061490A1 (es) | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 | |
MX2011011485A (es) | Sulfonamidas nematocidas. | |
AR052866A1 (es) | Fenil-metanonas monociclicas sustituidas | |
PE20091376A1 (es) | Derivados de fenilamino como moduladores de beta-amiloide | |
CO5700757A2 (es) | Derivados de (3-oxo-3,4-dihidro-quinoxalin-2-il-amino)-benzamida y compuesto relacionado, como inhibidores de glucogeno fosforilasa para el tratamiento de la diabetes y obesidad | |
PE20060777A1 (es) | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas | |
PE20131463A1 (es) | Piperidino-dihidrotienopirimidinas sustituidas | |
PE20090601A1 (es) | Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 | |
ECSP066968A (es) | Compuestos de metil-aril o heteroaril-amida sustituida | |
PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
NZ592533A (en) | METHOD FOR THE PREPARATION OF N-(5-CHLORO-2-PYRIDINYL)-2-[[4-[(DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO]-5-METHOXY-BENZAMIDE, A FACTOR Xa INHIBITOR | |
CY1107008T1 (el) | Παραγωγο βενζιμιδαζολης και χρηση ως ανταγωνιστου υποδοχεα aii | |
NO20071642L (no) | N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger | |
PE20140192A1 (es) | Derivados de bencimidazol como inhibidores de cinasa pi3 | |
PE20050948A1 (es) | Compuestos de carbamoil-amina como inhibidores de la dipeptidil peptidasa iv | |
PE20110150A1 (es) | Amidofenoxiindazoles como inhibidores de c-met | |
CY1111671T1 (el) | Ετεροκυκλικη ενωση | |
PE20061303A1 (es) | Composicion farmaceutica que comprende oxaprozina | |
MX343596B (es) | Sulfonamidas nematocidas. | |
SMP201100019B (it) | Composti organici | |
RS52823B (en) | NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | |
ECSP088479A (es) | Derivados de oxadiazol | |
AR063788A1 (es) | Derivados de 5-hidroximetil-oxazolidin -2-ona | |
NO20082096L (no) | Azaindol-2-karboksamidderivativer | |
PE20090880A1 (es) | Compuestos heterociclicos como inhibidores de fosfatidilinositol 3-cinasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |