BRPI0512691A - compostos de oxazolidinona e composições e métodos relacionados a estes - Google Patents

compostos de oxazolidinona e composições e métodos relacionados a estes

Info

Publication number
BRPI0512691A
BRPI0512691A BRPI0512691-6A BRPI0512691A BRPI0512691A BR PI0512691 A BRPI0512691 A BR PI0512691A BR PI0512691 A BRPI0512691 A BR PI0512691A BR PI0512691 A BRPI0512691 A BR PI0512691A
Authority
BR
Brazil
Prior art keywords
oxazolidinone compounds
compounds
compositions
formula
methods related
Prior art date
Application number
BRPI0512691-6A
Other languages
English (en)
Inventor
Montserrat Cano
Albert Palomer
Antonio Guglietta
Original Assignee
Ferrer Internat S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internat S A filed Critical Ferrer Internat S A
Publication of BRPI0512691A publication Critical patent/BRPI0512691A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

COMPOSTOS DE OXAZOLIDINONA E COMPOSIçõES E MéTODOS RELACIONADOS A ESTES A presente invenção refere-se a novas oxazolidinonas da fórmula (I) onde R~ 1~, R~ 2~, R~ 3~ e R~ 4~ são independentemente selecionados de hidrogênio, F e CI; A é selecionado de certos heterociclos opcionalmente substituídos; X é selecionado de O, S, NRs e CR~ 8~Rg; Y é selecionado de O, S, SO, SO~ 2~, NO, NR~ 11~ e CR~ 11~R~ 12~; e n é selecionado de 0 e 1. A invenção também fornece diferentes processos para a preparação de tais compostos. Compostos de oxazolidinona de fórmula (I) são ativos contra patógenos humanos e veterinários Gram-positivos e alguns Gram-negativos com uma fraca atividade inibidora de monoamina oxidase (MAO). Eles são úteis para o tratamento de infecções bacterianas.
BRPI0512691-6A 2004-07-29 2005-07-26 compostos de oxazolidinona e composições e métodos relacionados a estes BRPI0512691A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04103657 2004-07-29
PCT/EP2005/053627 WO2006010756A1 (en) 2004-07-29 2005-07-26 Oxazolidinone compounds and compositions and methods related thereto

Publications (1)

Publication Number Publication Date
BRPI0512691A true BRPI0512691A (pt) 2008-04-01

Family

ID=35355681

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512691-6A BRPI0512691A (pt) 2004-07-29 2005-07-26 compostos de oxazolidinona e composições e métodos relacionados a estes

Country Status (17)

Country Link
US (1) US20090005369A1 (pt)
EP (1) EP1786805A1 (pt)
JP (1) JP2008508236A (pt)
KR (1) KR20070048227A (pt)
CN (1) CN101027296A (pt)
AR (1) AR050426A1 (pt)
AU (1) AU2005266318A1 (pt)
BR (1) BRPI0512691A (pt)
CA (1) CA2574668A1 (pt)
MX (1) MX2007001065A (pt)
NO (1) NO20070870L (pt)
PA (1) PA8640401A1 (pt)
PE (1) PE20060619A1 (pt)
RU (1) RU2007107490A (pt)
TW (1) TW200612923A (pt)
UY (1) UY29012A1 (pt)
WO (1) WO2006010756A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
EP2072513A1 (en) 2007-12-17 2009-06-24 Ferrer Internacional, S.A. A cyano piperidinyl-phenil-oxazolidinone and use thereof
EP2655362A1 (en) 2010-12-22 2013-10-30 Abbvie Inc. Hepatitis c inhibitors and uses thereof
CN103420996B (zh) * 2013-09-07 2015-06-24 吉首大学 苯并吡喃酮-胺甲基-噁唑烷酮类化合物及其制法和用途
CN103483329B (zh) * 2013-09-07 2015-08-05 吉首大学 呋喃酮-芳基-噁唑烷酮型化合物及其制法和用途
CN103420995B (zh) * 2013-09-07 2015-07-01 吉首大学 噁唑烷酮-烷胺基-呋喃酮型化合物及其制法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1252101A (pt) * 1969-03-18 1971-11-03
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10105989A1 (de) * 2001-02-09 2002-08-14 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
EP1448536A1 (en) * 2001-11-29 2004-08-25 Merck & Co., Inc. Cyclopropyl-containing oxazolidinone antibiotics and derivatives thereof
TW200302095A (en) 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
WO2003084534A1 (en) * 2002-03-29 2003-10-16 Pharmacia & Upjohn Company Llc Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials

Also Published As

Publication number Publication date
TW200612923A (en) 2006-05-01
KR20070048227A (ko) 2007-05-08
NO20070870L (no) 2007-04-16
RU2007107490A (ru) 2008-09-10
UY29012A1 (es) 2005-10-31
MX2007001065A (es) 2007-04-10
AR050426A1 (es) 2006-10-25
PE20060619A1 (es) 2006-07-11
EP1786805A1 (en) 2007-05-23
PA8640401A1 (es) 2006-03-24
AU2005266318A1 (en) 2006-02-02
CN101027296A (zh) 2007-08-29
JP2008508236A (ja) 2008-03-21
WO2006010756A1 (en) 2006-02-02
CA2574668A1 (en) 2006-02-02
US20090005369A1 (en) 2009-01-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.