ES2167717T3 - Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. - Google Patents

Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos.

Info

Publication number
ES2167717T3
ES2167717T3 ES97908655T ES97908655T ES2167717T3 ES 2167717 T3 ES2167717 T3 ES 2167717T3 ES 97908655 T ES97908655 T ES 97908655T ES 97908655 T ES97908655 T ES 97908655T ES 2167717 T3 ES2167717 T3 ES 2167717T3
Authority
ES
Spain
Prior art keywords
amino acids
pharmaceutical agents
acids replaced
new
cyclical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97908655T
Other languages
English (en)
Inventor
David Christopher Horwell
Justin S Bryans
Clare O Kneen
Andrew I Morrell
Giles S Ratcliffe
Johannes Hartenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2167717T3 publication Critical patent/ES2167717T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS AMINOACIDOS CICLICOS SUSTITUIDOS DE FORMULA (I), QUE SON UTILES COMO AGENTES PARA EL TRATAMIENTO DE LA EPILEPSIA, ATAQUE DE DEBILIDAD, HIPOQUINESIA, ALTERACIONES CRANEALES, ALTERACIONES NEURODEGENERATIVAS, DEPRESION, ANSIEDAD, PANICO, DOLOR Y ALTERACIONES NEUROPATOLOGICAS. SE PRESENTAN ASIMISMO PROCEDIMIENTOS PARA LA PREPARACION E INTERMEDIARIOS UTILIZADOS EN DICHA PREPARACION.
ES97908655T 1996-03-14 1997-02-18 Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. Expired - Lifetime ES2167717T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1343296P 1996-03-14 1996-03-14

Publications (1)

Publication Number Publication Date
ES2167717T3 true ES2167717T3 (es) 2002-05-16

Family

ID=21759938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97908655T Expired - Lifetime ES2167717T3 (es) 1996-03-14 1997-02-18 Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos.

Country Status (29)

Country Link
US (1) US6103932A (es)
EP (1) EP0888286B1 (es)
JP (1) JP2000506861A (es)
KR (1) KR100512506B1 (es)
AT (1) ATE207878T1 (es)
AU (1) AU734173B2 (es)
BG (1) BG63662B1 (es)
BR (1) BR9708200A (es)
CA (1) CA2244912C (es)
CZ (1) CZ293759B6 (es)
DE (1) DE69707842T2 (es)
DK (2) DK0888286T3 (es)
EA (1) EA002765B1 (es)
EE (1) EE9800309A (es)
ES (1) ES2167717T3 (es)
GE (1) GEP20012413B (es)
HU (1) HU224720B1 (es)
IL (1) IL125544A (es)
IS (1) IS1990B (es)
MX (1) MX9806069A (es)
NO (1) NO984205L (es)
NZ (1) NZ331143A (es)
PL (1) PL185991B1 (es)
PT (1) PT888286E (es)
SK (1) SK283295B6 (es)
TR (1) TR199801807T2 (es)
UA (1) UA49011C2 (es)
WO (1) WO1997033858A1 (es)
ZA (1) ZA972200B (es)

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Also Published As

Publication number Publication date
SK123898A3 (en) 2000-04-10
IS4819A (is) 1998-08-10
ATE207878T1 (de) 2001-11-15
NO984205D0 (no) 1998-09-11
MX9806069A (es) 1998-11-30
HUP9902136A2 (hu) 1999-10-28
HUP9902136A3 (en) 2000-03-28
CZ293759B6 (cs) 2004-07-14
NO984205L (no) 1998-09-14
IS1990B (is) 2005-02-15
SK283295B6 (sk) 2003-05-02
BR9708200A (pt) 1999-07-27
DE69707842D1 (de) 2001-12-06
NZ331143A (en) 2001-06-29
PL328816A1 (en) 1999-02-15
PT888286E (pt) 2002-04-29
EP0888286B1 (en) 2001-10-31
EA199800798A1 (ru) 1999-04-29
DK0888285T3 (da) 2002-04-08
CZ286398A3 (cs) 1999-03-17
CA2244912C (en) 2005-07-12
US6103932A (en) 2000-08-15
KR19990087756A (ko) 1999-12-27
KR100512506B1 (ko) 2005-12-21
BG63662B1 (bg) 2002-08-30
TR199801807T2 (xx) 1998-12-21
PL185991B1 (pl) 2003-09-30
EE9800309A (et) 1999-02-15
EA002765B1 (ru) 2002-08-29
IL125544A0 (en) 1999-03-12
BG102733A (en) 1999-04-30
DE69707842T2 (de) 2002-05-16
DK0888286T3 (da) 2002-02-18
AU734173B2 (en) 2001-06-07
GEP20012413B (en) 2001-04-25
IL125544A (en) 2002-03-10
EP0888286A1 (en) 1999-01-07
AU2051197A (en) 1997-10-01
UA49011C2 (uk) 2002-09-16
ZA972200B (en) 1997-09-17
HU224720B1 (en) 2006-01-30
JP2000506861A (ja) 2000-06-06
WO1997033858A1 (en) 1997-09-18
CA2244912A1 (en) 1997-09-18

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