IS1990B - Nýstárlegar staðgengnar hringamínósýrur notaðar til lyfjagerðar - Google Patents
Nýstárlegar staðgengnar hringamínósýrur notaðar til lyfjagerðarInfo
- Publication number
- IS1990B IS1990B IS4819A IS4819A IS1990B IS 1990 B IS1990 B IS 1990B IS 4819 A IS4819 A IS 4819A IS 4819 A IS4819 A IS 4819A IS 1990 B IS1990 B IS 1990B
- Authority
- IS
- Iceland
- Prior art keywords
- amino acids
- pct
- cyclic amino
- innovative
- acids used
- Prior art date
Links
- -1 cyclic amino acids Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1343296P | 1996-03-14 | 1996-03-14 | |
| PCT/US1997/002295 WO1997033858A1 (en) | 1996-03-14 | 1997-02-18 | Novel substituted cyclic amino acids as pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS4819A IS4819A (is) | 1998-08-10 |
| IS1990B true IS1990B (is) | 2005-02-15 |
Family
ID=21759938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS4819A IS1990B (is) | 1996-03-14 | 1998-08-10 | Nýstárlegar staðgengnar hringamínósýrur notaðar til lyfjagerðar |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6103932A (is) |
| EP (1) | EP0888286B1 (is) |
| JP (1) | JP2000506861A (is) |
| KR (1) | KR100512506B1 (is) |
| AT (1) | ATE207878T1 (is) |
| AU (1) | AU734173B2 (is) |
| BG (1) | BG63662B1 (is) |
| BR (1) | BR9708200A (is) |
| CA (1) | CA2244912C (is) |
| CZ (1) | CZ293759B6 (is) |
| DE (1) | DE69707842T2 (is) |
| DK (2) | DK0888286T3 (is) |
| EA (1) | EA002765B1 (is) |
| EE (1) | EE9800309A (is) |
| ES (1) | ES2167717T3 (is) |
| GE (1) | GEP20012413B (is) |
| HU (1) | HU224720B1 (is) |
| IL (1) | IL125544A (is) |
| IS (1) | IS1990B (is) |
| MX (1) | MX9806069A (is) |
| NO (1) | NO984205L (is) |
| NZ (1) | NZ331143A (is) |
| PL (1) | PL185991B1 (is) |
| PT (1) | PT888286E (is) |
| SK (1) | SK283295B6 (is) |
| TR (1) | TR199801807T2 (is) |
| UA (1) | UA49011C2 (is) |
| WO (1) | WO1997033858A1 (is) |
| ZA (1) | ZA972200B (is) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2200184T7 (es) | 1996-07-24 | 2015-02-10 | Warner-Lambert Company Llc | Isobutilgaba y sus derivados para el tratamiento del dolor |
| KR100589066B1 (ko) * | 1997-10-27 | 2006-06-13 | 워너-램버트 캄파니 엘엘씨 | 약제로서 유용한 시클릭 아미노산 및 그의 유도체 |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| KR20010033158A (ko) * | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 1-치환-1-아미노메틸-시클로알칸 유도체 (=가바펜틴동족체), 그의 제조법 및 신경성 질환 치료에 있어서 그의용도 |
| BR9911917A (pt) | 1998-07-09 | 2001-03-27 | Warner Lambert Co | Composições compreendendo análogos de gaba e cafeìna |
| EP1031350A1 (en) * | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
| US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
| OA11759A (en) * | 1999-12-08 | 2005-07-19 | Penn State Res Found | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy. |
| EP1267896A1 (en) * | 2000-03-28 | 2003-01-02 | Robert J. Delorenzo | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
| DE10048715A1 (de) * | 2000-09-30 | 2004-05-19 | Grünenthal GmbH | Verwendung von Aminosäure zur Behandlung von Schmerz |
| EP1361847A2 (en) | 2000-10-06 | 2003-11-19 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| US6992076B2 (en) * | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| CZ20031432A3 (cs) | 2000-11-02 | 2003-12-17 | Teva Pharmaceutical Industries Ltd. | Zlepšený způsob výroby meziproduktu gabapentinu |
| JP2004524339A (ja) * | 2001-03-16 | 2004-08-12 | ソルケム イタリアーナ エス.ピー.エイ. | 環状アミノ酸の調製方法 |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| EP1902714B1 (en) * | 2001-06-11 | 2012-01-11 | XenoPort, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| US8048917B2 (en) * | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| EP1412324A4 (en) * | 2001-06-11 | 2004-09-29 | Xenoport Inc | AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS |
| US20060167032A1 (en) * | 2002-01-16 | 2006-07-27 | Galer Bradley S | Pharmaceutical composition and method for treating disorders of the central nervous system |
| EP1485082A4 (en) * | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
| AU2003222033A1 (en) * | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| WO2003094842A2 (en) * | 2002-05-07 | 2003-11-20 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US7183259B2 (en) * | 2002-05-17 | 2007-02-27 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| US7060727B2 (en) * | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| AU2003297909A1 (en) * | 2002-12-11 | 2004-06-30 | Xenoport, Inc. | Orally administered dosage forms of fused gaba analog prodrugs having reduced toxicity |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| EP1572173B1 (en) | 2002-12-13 | 2010-04-28 | Warner-Lambert Company LLC | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| GB0301143D0 (en) * | 2003-01-17 | 2003-02-19 | Amedis Pharm Ltd | Compounds and their use |
| KR20050119676A (ko) * | 2003-03-31 | 2005-12-21 | 제노포트 인코포레이티드 | 가바 유사체의 프로드러그를 사용한 열성 홍조의 치료 또는예방 |
| AU2004272111A1 (en) * | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Treating and/or preventing urinary incontinence using prodrugs of GABA analogs |
| DE602004024317D1 (de) | 2003-09-12 | 2010-01-07 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
| SG146643A1 (en) | 2003-09-17 | 2008-10-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| PL1677767T3 (pl) * | 2003-10-14 | 2011-12-30 | Xenoport Inc | Krystaliczna postać analogu kwasu gamma-aminomasłowego |
| DK1691811T3 (da) | 2003-12-11 | 2014-10-20 | Sunovion Pharmaceuticals Inc | Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression |
| US7632864B2 (en) * | 2004-03-17 | 2009-12-15 | Hikal Ltd. | Gabapentin analogues and process thereof |
| CA2570255A1 (en) | 2004-03-17 | 2005-09-22 | Hikal Limited | 4-t-butylgabapentin and its synthesis |
| US20050209332A1 (en) * | 2004-03-17 | 2005-09-22 | Hikal Limited | Gabapentin analogues and process thereof |
| CA2584338C (en) | 2004-11-04 | 2013-08-06 | Xenoport, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| AU2007332904A1 (en) * | 2006-12-08 | 2008-06-19 | Xenoport, Inc. | Use of prodrugs of GABA analogs for treating diseases |
| CA2673545A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| US8828665B2 (en) | 2007-02-16 | 2014-09-09 | Ark Diagnostics, Inc. | Compounds and methods for use in detecting gabapentin |
| TW200908957A (en) * | 2007-06-15 | 2009-03-01 | Xenoport Inc | Use of prodrugs of GABA analogs, antispasticity agents, and prodrugs of GABAB receptor agonists for treating spasticity |
| US20090118365A1 (en) * | 2007-11-06 | 2009-05-07 | Xenoport, Inc | Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain |
| WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
| TWI380812B (zh) * | 2008-01-25 | 2013-01-01 | Xenoport Inc | (3s)-胺甲基-5-甲基己酸前藥之晶形及使用方法 |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| AU2009302241B2 (en) | 2008-10-08 | 2015-10-29 | Xgene Pharmaceutical Inc. | GABA conjugates and methods of use thereof |
| US8168756B2 (en) | 2008-10-24 | 2012-05-01 | Ark Diagnostics, Inc. | Levetiracetam immunoassays |
| EP2400989B1 (en) * | 2009-02-24 | 2016-08-10 | Nektar Therapeutics | Gabapentin-peg conjugates |
| US20110124705A1 (en) * | 2009-11-24 | 2011-05-26 | Xenoport, Inc. | Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
| US20110130454A1 (en) * | 2009-11-24 | 2011-06-02 | Xenoport, Inc. | Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| EP2945942B1 (en) | 2013-01-18 | 2018-05-09 | ARK Diagnostics, Inc. | Voriconazole immunoassays |
| WO2014117176A1 (en) | 2013-01-28 | 2014-07-31 | Lopez Hector L | Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor |
| ES2674704T3 (es) | 2013-02-13 | 2018-07-03 | Ark Diagnostics, Inc. | Inmunoensayos de posaconazol |
| CN112424158A (zh) | 2018-05-14 | 2021-02-26 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
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|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2543821C2 (de) * | 1974-12-21 | 1984-10-18 | Gödecke AG, 1000 Berlin | Bestimmte Salze und Ester von 1-Aminomethyl-1-cycloalkanessigsäuren und diese Verbindungen enthaltende Arzneimittel |
| DE2611690A1 (de) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
| DE2626467C2 (de) * | 1976-06-12 | 1984-11-22 | Gödecke AG, 1000 Berlin | 1-(N-Isopropylaminomethyl)-cyclohexanessigsäure, Verfahren zu deren Herstellung und diese Verbindung enthaltende Arzneimittel |
| US4960931A (en) * | 1988-05-02 | 1990-10-02 | Warner-Lambert Company | Gabapentin mohohydrate and a process for producing the same |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| YU162789A (en) * | 1988-09-01 | 1990-12-31 | Lonza Ag | 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones |
| US5319135A (en) * | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| DE3928184A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
| DE3928183A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| DE3928182A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
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| US5084479A (en) * | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
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| US5025035A (en) * | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
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| DE69318854T2 (de) * | 1993-03-04 | 1998-10-08 | Pfizer | Spiroazacyclischderivate als substanz p antagonisten |
| US5792796A (en) * | 1994-07-27 | 1998-08-11 | Warner-Lambert Company | Methods for treating anxiety and panic |
-
1997
- 1997-02-18 US US09/068,874 patent/US6103932A/en not_active Expired - Fee Related
- 1997-02-18 TR TR1998/01807T patent/TR199801807T2/xx unknown
- 1997-02-18 EP EP97908655A patent/EP0888286B1/en not_active Expired - Lifetime
- 1997-02-18 DK DK97908655T patent/DK0888286T3/da active
- 1997-02-18 CA CA002244912A patent/CA2244912C/en not_active Expired - Fee Related
- 1997-02-18 JP JP9532601A patent/JP2000506861A/ja not_active Ceased
- 1997-02-18 GE GEAP19974526A patent/GEP20012413B/en unknown
- 1997-02-18 DE DE69707842T patent/DE69707842T2/de not_active Expired - Fee Related
- 1997-02-18 CZ CZ19982863A patent/CZ293759B6/cs not_active IP Right Cessation
- 1997-02-18 UA UA98105386A patent/UA49011C2/uk unknown
- 1997-02-18 EE EE9800309A patent/EE9800309A/xx unknown
- 1997-02-18 KR KR10-1998-0707229A patent/KR100512506B1/ko not_active Expired - Fee Related
- 1997-02-18 IL IL12554497A patent/IL125544A/en not_active IP Right Cessation
- 1997-02-18 AU AU20511/97A patent/AU734173B2/en not_active Ceased
- 1997-02-18 DK DK97906630T patent/DK0888285T3/da active
- 1997-02-18 PT PT97908655T patent/PT888286E/pt unknown
- 1997-02-18 PL PL97328816A patent/PL185991B1/pl not_active IP Right Cessation
- 1997-02-18 WO PCT/US1997/002295 patent/WO1997033858A1/en not_active Ceased
- 1997-02-18 HU HU9902136A patent/HU224720B1/hu not_active IP Right Cessation
- 1997-02-18 SK SK1238-98A patent/SK283295B6/sk unknown
- 1997-02-18 ES ES97908655T patent/ES2167717T3/es not_active Expired - Lifetime
- 1997-02-18 EA EA199800798A patent/EA002765B1/ru unknown
- 1997-02-18 AT AT97908655T patent/ATE207878T1/de not_active IP Right Cessation
- 1997-02-18 BR BR9708200A patent/BR9708200A/pt not_active Application Discontinuation
- 1997-02-18 NZ NZ331143A patent/NZ331143A/en unknown
- 1997-03-13 ZA ZA9702200A patent/ZA972200B/xx unknown
-
1998
- 1998-07-28 MX MX9806069A patent/MX9806069A/es active IP Right Grant
- 1998-08-10 IS IS4819A patent/IS1990B/is unknown
- 1998-08-28 BG BG102733A patent/BG63662B1/bg unknown
- 1998-09-11 NO NO984205A patent/NO984205L/no not_active Application Discontinuation
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