HK1044933B - 支鏈氨基酸依賴性氨基轉移酶的抑制劑及其在治療糖尿病性視網膜病中的應用 - Google Patents
支鏈氨基酸依賴性氨基轉移酶的抑制劑及其在治療糖尿病性視網膜病中的應用Info
- Publication number
- HK1044933B HK1044933B HK02106385.8A HK02106385A HK1044933B HK 1044933 B HK1044933 B HK 1044933B HK 02106385 A HK02106385 A HK 02106385A HK 1044933 B HK1044933 B HK 1044933B
- Authority
- HK
- Hong Kong
- Prior art keywords
- aminotranserase
- inhibitors
- dependent
- treatment
- amino acid
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16963599P | 1999-12-08 | 1999-12-08 | |
US17539900P | 2000-01-11 | 2000-01-11 | |
US23002000P | 2000-09-05 | 2000-09-05 | |
PCT/US2000/030769 WO2001042191A1 (en) | 1999-12-08 | 2000-11-08 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1044933A1 HK1044933A1 (en) | 2002-11-08 |
HK1044933B true HK1044933B (zh) | 2005-06-03 |
Family
ID=27389690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02106385.8A HK1044933B (zh) | 1999-12-08 | 2002-08-29 | 支鏈氨基酸依賴性氨基轉移酶的抑制劑及其在治療糖尿病性視網膜病中的應用 |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP1157000B1 (zh) |
JP (1) | JP2003516379A (zh) |
KR (1) | KR20010101811A (zh) |
CN (2) | CN1626069A (zh) |
AP (1) | AP2001002242A0 (zh) |
AR (1) | AR037738A1 (zh) |
AT (1) | ATE308510T1 (zh) |
AU (1) | AU784553B2 (zh) |
BG (1) | BG105875A (zh) |
BR (1) | BR0008443A (zh) |
CA (1) | CA2361647A1 (zh) |
CO (1) | CO5280055A1 (zh) |
CZ (1) | CZ20012758A3 (zh) |
DE (1) | DE60023657T2 (zh) |
DZ (1) | DZ3141A1 (zh) |
EA (1) | EA006597B1 (zh) |
EE (1) | EE200100416A (zh) |
ES (1) | ES2252075T3 (zh) |
GE (1) | GEP20043298B (zh) |
HK (1) | HK1044933B (zh) |
HR (1) | HRP20010581A2 (zh) |
HU (1) | HUP0200570A3 (zh) |
IS (1) | IS6033A (zh) |
MA (1) | MA26777A1 (zh) |
MX (1) | MXPA01008085A (zh) |
NO (1) | NO20013844L (zh) |
OA (1) | OA11759A (zh) |
PE (1) | PE20010929A1 (zh) |
PL (1) | PL349193A1 (zh) |
SK (1) | SK11022001A3 (zh) |
UY (1) | UY26474A1 (zh) |
WO (1) | WO2001042191A1 (zh) |
YU (1) | YU57401A (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
AU2002310409C1 (en) * | 2001-06-11 | 2008-04-17 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
MXPA02010430A (es) * | 2001-11-27 | 2003-06-02 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
DE602004010135T2 (de) * | 2004-09-20 | 2008-09-04 | Kao Corp. | Verfahren zur Herstellung von Lactonen und deren Verwendung als Geruchsstoffe |
EP1811986B1 (en) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Gabapentin prodrug sustained release oral dosage forms |
WO2008103319A2 (en) * | 2007-02-16 | 2008-08-28 | Ark Diagnostics, Inc. | Compounds and methods for use in detecting gabapentin |
WO2008155619A2 (en) * | 2007-06-21 | 2008-12-24 | Pfizer Inc. | Preparation of optically-active cyclic amino acids |
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
EP2481801A1 (en) | 2011-01-28 | 2012-08-01 | Deutsches Krebsforschungszentrum | Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia |
US10941109B2 (en) | 2011-06-13 | 2021-03-09 | Ergon Pharmaceuticals Llc | Compositions and methods of treatment using a BCAT1 inhibitor |
JP6053768B2 (ja) * | 2011-06-13 | 2016-12-27 | エルゴン ファーマシューティカルズ エルエルシー | Bcat1阻害剤を使用する治療方法 |
CN113694202B (zh) * | 2020-06-29 | 2023-03-31 | 江苏省中医院 | Ass1或bckdk抑制剂在制备治疗溃疡性结肠炎的药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2167717T3 (es) * | 1996-03-14 | 2002-05-16 | Warner Lambert Co | Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. |
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2000
- 2000-11-08 ES ES00977094T patent/ES2252075T3/es not_active Expired - Lifetime
- 2000-11-08 CN CNA2004100641172A patent/CN1626069A/zh active Pending
- 2000-11-08 EA EA200100791A patent/EA006597B1/ru not_active IP Right Cessation
- 2000-11-08 BR BR0008443-3A patent/BR0008443A/pt not_active IP Right Cessation
- 2000-11-08 SK SK1102-2001A patent/SK11022001A3/sk unknown
- 2000-11-08 HU HU0200570A patent/HUP0200570A3/hu unknown
- 2000-11-08 KR KR1020017009951A patent/KR20010101811A/ko not_active Application Discontinuation
- 2000-11-08 DZ DZ003141A patent/DZ3141A1/xx active
- 2000-11-08 GE GE4559A patent/GEP20043298B/en unknown
- 2000-11-08 YU YU57401A patent/YU57401A/sh unknown
- 2000-11-08 EP EP00977094A patent/EP1157000B1/en not_active Expired - Lifetime
- 2000-11-08 OA OA1200100208A patent/OA11759A/en unknown
- 2000-11-08 AP APAP/P/2001/002242A patent/AP2001002242A0/en unknown
- 2000-11-08 AU AU14779/01A patent/AU784553B2/en not_active Ceased
- 2000-11-08 DE DE60023657T patent/DE60023657T2/de not_active Expired - Fee Related
- 2000-11-08 JP JP2001543493A patent/JP2003516379A/ja active Pending
- 2000-11-08 CA CA002361647A patent/CA2361647A1/en not_active Abandoned
- 2000-11-08 AT AT00977094T patent/ATE308510T1/de not_active IP Right Cessation
- 2000-11-08 EE EEP200100416A patent/EE200100416A/xx unknown
- 2000-11-08 CZ CZ20012758A patent/CZ20012758A3/cs unknown
- 2000-11-08 CN CNB008052670A patent/CN1170811C/zh not_active Expired - Fee Related
- 2000-11-08 MX MXPA01008085A patent/MXPA01008085A/es unknown
- 2000-11-08 WO PCT/US2000/030769 patent/WO2001042191A1/en active IP Right Grant
- 2000-11-08 PL PL00349193A patent/PL349193A1/xx not_active Application Discontinuation
- 2000-12-07 AR ARP000106493A patent/AR037738A1/es not_active Application Discontinuation
- 2000-12-07 PE PE2000001315A patent/PE20010929A1/es not_active Application Discontinuation
- 2000-12-07 CO CO00093679A patent/CO5280055A1/es not_active Application Discontinuation
- 2000-12-07 UY UY26474A patent/UY26474A1/es not_active Application Discontinuation
-
2001
- 2001-07-31 IS IS6033A patent/IS6033A/is unknown
- 2001-08-03 HR HR20010581A patent/HRP20010581A2/hr not_active Application Discontinuation
- 2001-08-07 NO NO20013844A patent/NO20013844L/no unknown
- 2001-09-04 MA MA26317A patent/MA26777A1/fr unknown
- 2001-09-05 BG BG105875A patent/BG105875A/xx unknown
-
2002
- 2002-08-29 HK HK02106385.8A patent/HK1044933B/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20081108 |