HK1044545A1 - 貝他分泌酶組合物及其方法 - Google Patents
貝他分泌酶組合物及其方法Info
- Publication number
- HK1044545A1 HK1044545A1 HK02104538.9A HK02104538A HK1044545A1 HK 1044545 A1 HK1044545 A1 HK 1044545A1 HK 02104538 A HK02104538 A HK 02104538A HK 1044545 A1 HK1044545 A1 HK 1044545A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- compositions
- human beta
- secretase enzyme
- secretase
- Prior art date
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11957199P | 1999-02-10 | 1999-02-10 | |
US13917299P | 1999-06-15 | 1999-06-15 | |
PCT/US2000/003819 WO2000047618A2 (en) | 1999-02-10 | 2000-02-10 | HUMAN β-SECRETASE ENZYME, INHIBITORS AND THEIR COMPOSITIONS AND USES |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1044545A1 true HK1044545A1 (zh) | 2002-10-25 |
Family
ID=26817477
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02104538.9A HK1044545A1 (zh) | 1999-02-10 | 2002-06-18 | 貝他分泌酶組合物及其方法 |
HK02104530.7A HK1044543B (zh) | 1999-02-10 | 2002-06-18 | 貝他分泌酶組合物及其方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02104530.7A HK1044543B (zh) | 1999-02-10 | 2002-06-18 | 貝他分泌酶組合物及其方法 |
Country Status (10)
Country | Link |
---|---|
US (3) | US6627739B1 (zh) |
EP (1) | EP1165609A2 (zh) |
JP (1) | JP4653318B2 (zh) |
CN (1) | CN1390232A (zh) |
AU (1) | AU4000900A (zh) |
CA (1) | CA2359785A1 (zh) |
GB (1) | GB2364059B (zh) |
HK (2) | HK1044545A1 (zh) |
NZ (1) | NZ534876A (zh) |
WO (1) | WO2000047618A2 (zh) |
Families Citing this family (67)
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US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
US6699671B1 (en) | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
US20040234976A1 (en) * | 1998-09-24 | 2004-11-25 | Gurney Mark E. | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
US7115410B1 (en) | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
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AU3770800A (en) * | 1999-03-26 | 2000-10-16 | Amgen, Inc. | Beta secretase genes and polypeptides |
US7087399B1 (en) * | 1999-05-13 | 2006-08-08 | Scios, Inc. | β-secretase and modulation of β-secretase activity |
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US6545127B1 (en) | 1999-06-28 | 2003-04-08 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
EP1496124A1 (en) * | 1999-06-28 | 2005-01-12 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
US20090162883A1 (en) * | 1999-09-23 | 2009-06-25 | Pharmacia & Upjohn Company | Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof |
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JP2004504018A (ja) | 2000-07-19 | 2004-02-12 | ファルマシア・アンド・アップジョン・カンパニー | β−セレクターゼ活性の基質およびアッセイ |
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GB9925136D0 (en) | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
US6361975B1 (en) | 1999-11-16 | 2002-03-26 | Smithkline Beecham Corporation | Mouse aspartic secretase-2(mASP-2) |
US6291223B1 (en) | 1999-11-23 | 2001-09-18 | Smithkline Beecham Corporation | Mouse aspartic secretase-1 (mASP1) |
-
2000
- 2000-02-10 WO PCT/US2000/003819 patent/WO2000047618A2/en active Application Filing
- 2000-02-10 CA CA002359785A patent/CA2359785A1/en not_active Abandoned
- 2000-02-10 GB GB0121314A patent/GB2364059B/en not_active Expired - Fee Related
- 2000-02-10 CN CN00806471A patent/CN1390232A/zh active Pending
- 2000-02-10 NZ NZ534876A patent/NZ534876A/en not_active IP Right Cessation
- 2000-02-10 AU AU40009/00A patent/AU4000900A/en not_active Abandoned
- 2000-02-10 EP EP00919298A patent/EP1165609A2/en not_active Ceased
- 2000-02-10 JP JP2000598533A patent/JP4653318B2/ja not_active Expired - Fee Related
- 2000-11-28 US US09/724,566 patent/US6627739B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,571 patent/US7067271B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,569 patent/US7109017B1/en not_active Expired - Fee Related
-
2002
- 2002-06-18 HK HK02104538.9A patent/HK1044545A1/zh unknown
- 2002-06-18 HK HK02104530.7A patent/HK1044543B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB0121314D0 (en) | 2001-10-24 |
GB2364059A (en) | 2002-01-16 |
AU4000900A (en) | 2000-08-29 |
JP2003524393A (ja) | 2003-08-19 |
WO2000047618A9 (en) | 2001-10-25 |
US7109017B1 (en) | 2006-09-19 |
EP1165609A2 (en) | 2002-01-02 |
JP4653318B2 (ja) | 2011-03-16 |
HK1044543B (zh) | 2004-12-03 |
NZ534876A (en) | 2006-02-24 |
US7067271B1 (en) | 2006-06-27 |
WO2000047618A3 (en) | 2001-09-07 |
WO2000047618A2 (en) | 2000-08-17 |
US6627739B1 (en) | 2003-09-30 |
GB2364059B (en) | 2004-01-14 |
HK1044543A1 (en) | 2002-10-25 |
CA2359785A1 (en) | 2000-08-17 |
CN1390232A (zh) | 2003-01-08 |
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