TR200003194T2 - Hastalık tedavisine mahsus sPLA2 önleyici bileşikler - Google Patents

Hastalık tedavisine mahsus sPLA2 önleyici bileşikler

Info

Publication number
TR200003194T2
TR200003194T2 TR2000/03194T TR200003194T TR200003194T2 TR 200003194 T2 TR200003194 T2 TR 200003194T2 TR 2000/03194 T TR2000/03194 T TR 2000/03194T TR 200003194 T TR200003194 T TR 200003194T TR 200003194 T2 TR200003194 T2 TR 200003194T2
Authority
TR
Turkey
Prior art keywords
inhibitory compounds
disease therapy
spla2
spla2 inhibitory
spla2 inhibitor
Prior art date
Application number
TR2000/03194T
Other languages
English (en)
Inventor
Louis Macias William
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200003194T2 publication Critical patent/TR200003194T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bir 1H-indol-3-glioksilamid sPLA2 önleyicisi gibi, bir sPLA2 önleyicisinin tedavi edici etkin bir miktarinin bunun ihtiyaci içinde olan bir insana ilaç olarak verilmesi ile bagirsak iltihabi hastaliginin tedavi edilmesine mahsus bir metot açiklanmaktadir.
TR2000/03194T 1998-05-01 1999-04-20 Hastalık tedavisine mahsus sPLA2 önleyici bileşikler TR200003194T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8387498P 1998-05-01 1998-05-01

Publications (1)

Publication Number Publication Date
TR200003194T2 true TR200003194T2 (tr) 2001-03-21

Family

ID=22181224

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03194T TR200003194T2 (tr) 1998-05-01 1999-04-20 Hastalık tedavisine mahsus sPLA2 önleyici bileşikler

Country Status (20)

Country Link
US (1) US6340699B1 (tr)
EP (1) EP1084108A4 (tr)
JP (1) JP2002513783A (tr)
KR (1) KR20010043190A (tr)
CN (1) CN1299348A (tr)
AU (1) AU3656299A (tr)
BR (1) BR9910095A (tr)
CA (1) CA2330856A1 (tr)
CZ (1) CZ20004052A3 (tr)
EA (1) EA200001140A1 (tr)
HR (1) HRP20000739A2 (tr)
HU (1) HUP0102243A2 (tr)
ID (1) ID27153A (tr)
IL (1) IL139019A0 (tr)
NO (1) NO20005479L (tr)
PL (1) PL343708A1 (tr)
SK (1) SK16342000A3 (tr)
TR (1) TR200003194T2 (tr)
WO (1) WO1999057100A1 (tr)
ZA (1) ZA200005563B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
AU2001236440A1 (en) * 2000-01-25 2001-08-07 Eli Lilly And Company Method for the treatment of inflammation with spla2 inhibitors
JPWO2002000621A1 (ja) * 2000-06-29 2004-04-22 塩野義製薬株式会社 Ｘ型ｓＰＬＡ２阻害作用を有する化合物
IL154029A0 (en) * 2000-07-24 2003-07-31 Dow Global Technologies Inc Thermoplastic superabsorbent polymer blend compositions and their preparation
AU2006311766A1 (en) * 2005-11-03 2007-05-18 Ilypsa, Inc. Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors
CN101983188A (zh) * 2008-04-01 2011-03-02 安斯泰来制药有限公司 吲哚啉酮化合物
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
US9290752B2 (en) 2013-03-13 2016-03-22 Sunny Delight Beverages Co. Process for enhancing the amylase inhibitory efficacy from phaseolus vulgaris extracts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356919A (en) 1991-05-30 1994-10-18 G. D. Searle & Co. Leukotriene B4 synthesis inhibitors
DE4218096A1 (de) 1992-06-02 1993-12-09 Boehringer Mannheim Gmbh Spiro-oxetane, Verfahren zu ihrer Herstellung und Arzneimittel
DE4323409A1 (de) 1993-07-13 1995-01-19 Boehringer Mannheim Gmbh Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel
PT675110E (pt) 1994-04-01 2002-11-29 Lilly Co Eli 1h-indole-3-glioxilamidas inibidoras da spla2
WO1995033462A1 (en) * 1994-06-02 1995-12-14 Smithkline Beecham Corporation Anti-inflammatory compounds
NZ298145A (en) * 1994-12-29 1998-08-26 Yamanouchi Pharma Co Ltd Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament
BR9713261A (pt) 1996-10-30 2000-03-28 Lilly Co Eli Tricìclicos substituìdos
PL343007A1 (en) * 1998-02-25 2001-07-30 Genetics Inst Inhibitors of phospholipase enzymes

Also Published As

Publication number Publication date
WO1999057100A1 (en) 1999-11-11
CN1299348A (zh) 2001-06-13
HRP20000739A2 (en) 2001-10-31
KR20010043190A (ko) 2001-05-25
BR9910095A (pt) 2000-12-26
PL343708A1 (en) 2001-08-27
NO20005479D0 (no) 2000-10-31
CA2330856A1 (en) 1999-11-11
NO20005479L (no) 2000-12-20
ZA200005563B (en) 2002-01-10
ID27153A (id) 2001-03-08
JP2002513783A (ja) 2002-05-14
AU3656299A (en) 1999-11-23
EP1084108A1 (en) 2001-03-21
EA200001140A1 (ru) 2001-04-23
HUP0102243A2 (hu) 2001-10-28
SK16342000A3 (sk) 2002-04-04
EP1084108A4 (en) 2005-01-12
CZ20004052A3 (cs) 2002-05-15
US6340699B1 (en) 2002-01-22
IL139019A0 (en) 2001-11-25

Similar Documents

Publication Publication Date Title
CY1118651T1 (el) Αζακυκλικες ενωσεις για χρηση στην θεραπευτικη αντιμετωπιση ασθενειων που σχετιζονται με τη σεροτονινη
WO2001081312A3 (en) Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
DK1169060T3 (da) Natriumkanalblokkerpræparater og anvendelse deraf
EA200001223A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
AU7321598A (en) Use of cholinesterase inhibitors to treat disorders of attention
EA200001224A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
EA200700538A1 (ru) Соединения пиридиловых ингибиторов передачи сигналов белком hedgehog, способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе
PT988301E (pt) Acetais ciclicos de imidazolilo
EA199900494A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
ES2191069T3 (es) Diaril-2-(5h)-furanonas como inhibidores de cox-2.
UA49869C2 (uk) Нафтил-заміщені похідні бензимідазолу, фармацевтична композиція, спосіб лікування (варіанти) та спосіб інгібування людського фактора
EA200500859A1 (ru) Хинолинилпирролопиразолы
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
RU94044454A (ru) Ингибитор аутоимунных заболеваний
DE69825154D1 (de) Pyridazinone als inhibitoren von cyclooxygenase-2
TR200003194T2 (tr) Hastalık tedavisine mahsus sPLA2 önleyici bileşikler
PT1039900E (pt) Agentes terapeuticos
EA200601249A1 (ru) Пиперазины, пригодные для лечения боли
TR200101693T2 (tr) Lemfotoksin (LT) sentezlenme yolunun inhibitörleri kullanılarak foliküler lemfomaların tedavisi.
SE0004101D0 (sv) New use
DK0986393T3 (da) Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer
ATE293602T1 (de) 2-aminopyridine als inhibitoren von cyclooxygenase-2
TR200103526T2 (tr) Kardiyovaskular hastalıkların terapisi için aminotetralin türevi.
HK1080768A1 (en) Use of epothilone derivatives for the treatment ofhyperparathyroidism
HRP20050281A2 (en) Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes