EA200000723A1 - Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола - Google Patents

Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола

Info

Publication number
EA200000723A1
EA200000723A1 EA200000723A EA200000723A EA200000723A1 EA 200000723 A1 EA200000723 A1 EA 200000723A1 EA 200000723 A EA200000723 A EA 200000723A EA 200000723 A EA200000723 A EA 200000723A EA 200000723 A1 EA200000723 A1 EA 200000723A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diola
purin
tetrahydrofuran
derivatives
therapy
Prior art date
Application number
EA200000723A
Other languages
English (en)
Other versions
EA003194B1 (ru
Inventor
Чуэн Чен
Ричард Питер Чарлз Казинз
Брайан Кокс
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802066.2A external-priority patent/GB9802066D0/en
Priority claimed from GBGB9813528.8A external-priority patent/GB9813528D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200000723A1 publication Critical patent/EA200000723A1/ru
Publication of EA003194B1 publication Critical patent/EA003194B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Abstract

Согласно изобретению предложены новые соединения формулы (I), где значения R, Rи Rданы в описании, способы их получения, содержащие их препараты и их применение в терапии для лечения воспалительных заболеваний.Отчет о международном поиске был опубликован 1999.09.30.
EA200000723A 1998-01-31 1999-01-29 Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола, способы их получения, фармацевтическая композиция и способ лечения или профилактики воспалительных заболеваний с их применением EA003194B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9802066.2A GB9802066D0 (en) 1998-01-31 1998-01-31 Chemical compounds
GBGB9813528.8A GB9813528D0 (en) 1998-06-23 1998-06-23 Chemical compounds
PCT/EP1999/000503 WO1999038877A2 (en) 1998-01-31 1999-01-29 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES

Publications (2)

Publication Number Publication Date
EA200000723A1 true EA200000723A1 (ru) 2001-04-23
EA003194B1 EA003194B1 (ru) 2003-02-27

Family

ID=26313042

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000723A EA003194B1 (ru) 1998-01-31 1999-01-29 Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола, способы их получения, фармацевтическая композиция и способ лечения или профилактики воспалительных заболеваний с их применением

Country Status (39)

Country Link
US (1) US6762170B1 (ru)
EP (1) EP1051425B1 (ru)
JP (1) JP2002501928A (ru)
KR (1) KR20010034473A (ru)
CN (1) CN1289338A (ru)
AP (1) AP2000001875A0 (ru)
AR (1) AR014508A1 (ru)
AT (1) ATE226957T1 (ru)
AU (1) AU757183B2 (ru)
BG (1) BG63783B1 (ru)
BR (1) BR9907270A (ru)
CA (1) CA2318278A1 (ru)
CO (1) CO4980872A1 (ru)
DE (1) DE69903708T2 (ru)
DK (1) DK1051425T3 (ru)
EA (1) EA003194B1 (ru)
EE (1) EE200000441A (ru)
ES (1) ES2186330T3 (ru)
GE (1) GEP20022839B (ru)
HK (1) HK1030611A1 (ru)
HR (1) HRP20000511A2 (ru)
HU (1) HUP0101305A3 (ru)
ID (1) ID26326A (ru)
IL (1) IL137042A0 (ru)
IS (1) IS5550A (ru)
MA (1) MA26601A1 (ru)
NO (1) NO20003867D0 (ru)
NZ (1) NZ505452A (ru)
OA (1) OA11447A (ru)
PE (1) PE20000280A1 (ru)
PL (1) PL342670A1 (ru)
PT (1) PT1051425E (ru)
SI (1) SI1051425T1 (ru)
SK (1) SK11192000A3 (ru)
SV (1) SV1999000009A (ru)
TR (1) TR200002218T2 (ru)
TW (1) TW434250B (ru)
WO (1) WO1999038877A2 (ru)
YU (1) YU44900A (ru)

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Also Published As

Publication number Publication date
HUP0101305A3 (en) 2002-08-28
CO4980872A1 (es) 2000-11-27
BR9907270A (pt) 2000-10-24
JP2002501928A (ja) 2002-01-22
HK1030611A1 (en) 2001-05-11
AR014508A1 (es) 2001-02-28
EP1051425A2 (en) 2000-11-15
ES2186330T3 (es) 2003-05-01
IL137042A0 (en) 2001-06-14
DE69903708D1 (de) 2002-12-05
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CA2318278A1 (en) 1999-08-05
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US6762170B1 (en) 2004-07-13
MA26601A1 (fr) 2004-12-20
CN1289338A (zh) 2001-03-28
AU2719799A (en) 1999-08-16
DE69903708T2 (de) 2003-07-03
WO1999038877A3 (en) 1999-09-30
NZ505452A (en) 2003-01-31
NO20003867L (no) 2000-07-28
HUP0101305A2 (hu) 2002-04-29
TR200002218T2 (tr) 2000-12-21
WO1999038877A2 (en) 1999-08-05
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EE200000441A (et) 2001-12-17
PE20000280A1 (es) 2000-03-28
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EA003194B1 (ru) 2003-02-27
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