DK0986393T3 - Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer - Google Patents

Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer

Info

Publication number
DK0986393T3
DK0986393T3 DK98923772T DK98923772T DK0986393T3 DK 0986393 T3 DK0986393 T3 DK 0986393T3 DK 98923772 T DK98923772 T DK 98923772T DK 98923772 T DK98923772 T DK 98923772T DK 0986393 T3 DK0986393 T3 DK 0986393T3
Authority
DK
Denmark
Prior art keywords
cancer
nitroxide
prodrug
prophylactic
therapeutic treatment
Prior art date
Application number
DK98923772T
Other languages
English (en)
Inventor
James B Mitchell
Angelo Russo
Anne Marie Deluca
Murali Krishna Cherukuri
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of DK0986393T3 publication Critical patent/DK0986393T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK98923772T 1997-05-27 1998-05-27 Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer DK0986393T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4772497P 1997-05-27 1997-05-27
PCT/US1998/010685 WO1998053835A1 (en) 1997-05-27 1998-05-27 The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer

Publications (1)

Publication Number Publication Date
DK0986393T3 true DK0986393T3 (da) 2004-07-05

Family

ID=21950574

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98923772T DK0986393T3 (da) 1997-05-27 1998-05-27 Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer

Country Status (10)

Country Link
EP (1) EP0986393B1 (da)
JP (3) JP4856294B2 (da)
AT (1) ATE262330T1 (da)
AU (1) AU746505B2 (da)
CA (1) CA2289017C (da)
DE (1) DE69822626T8 (da)
DK (1) DK0986393T3 (da)
ES (1) ES2216286T3 (da)
PT (1) PT986393E (da)
WO (1) WO1998053835A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
CA2335986A1 (en) * 1998-06-26 2000-01-06 Simeng Suy Use of tempo and tempo derivatives for inducing cell death
US20040219201A1 (en) * 2001-12-06 2004-11-04 Yechezkel Barenholz Tempamine compositions and methods of use
CA2527522A1 (en) * 2003-05-29 2004-12-09 Kenneth Chang Methods of using nitroxides in conjunction with photosensitizers and sonosensitizers
JP2008528701A (ja) * 2005-02-02 2008-07-31 ミトス・ファーマシューティカルズ・インコーポレーテッド 腫瘍性疾患の治療又は予防に用いるためのニトロキシド類
US8466130B2 (en) 2009-09-04 2013-06-18 Colby Pharmaceutical Company Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers
EP2139522A2 (en) * 2007-03-06 2010-01-06 Colby Pharmaceutical Company Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers
WO2011066537A1 (en) 2009-11-30 2011-06-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitroxide therapy for the treatment of von hippel - lindau disease (vhl) and renal clear cell carcinoma (rcc)
US20180078539A1 (en) 2016-03-23 2018-03-22 Louis Habash T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide
US10231959B2 (en) 2016-03-23 2019-03-19 Louis Habash Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide
JP2019509352A (ja) * 2016-03-23 2019-04-04 ルイス ハバシュ， ヒトの被験物質をニトロキシドで処理することによってａｐｏｐｔｏｓｉｓ関連遺伝子の発現レベルを増加させる

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758580A (en) * 1985-06-26 1988-07-19 Yamanouchi Pharmaceutical Co., Ltd. Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts
DE59007645D1 (de) * 1990-06-21 1994-12-08 Edith Dr Huland Verwendung zytokinhaltiger Aerosole und zytokinhaltige Aerosole selbst.
US6605619B1 (en) * 1992-03-20 2003-08-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxides as protectors against oxidatives stress
WO1996025171A1 (en) * 1995-02-16 1996-08-22 F.Hoffmann-La Roche Ag Inhibition of angiogenesis using interleukin-12

Also Published As

Publication number Publication date
CA2289017A1 (en) 1998-12-03
JP4856294B2 (ja) 2012-01-18
AU746505B2 (en) 2002-05-02
JP2013121964A (ja) 2013-06-20
ES2216286T3 (es) 2004-10-16
ATE262330T1 (de) 2004-04-15
DE69822626D1 (de) 2004-04-29
WO1998053835A1 (en) 1998-12-03
JP2009185034A (ja) 2009-08-20
PT986393E (pt) 2004-06-30
JP2002500671A (ja) 2002-01-08
CA2289017C (en) 2008-07-22
DE69822626T2 (de) 2004-08-12
EP0986393A1 (en) 2000-03-22
EP0986393B1 (en) 2004-03-24
AU7598798A (en) 1998-12-30
DE69822626T8 (de) 2005-02-03
JP5270413B2 (ja) 2013-08-21

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