EA199901026A1 - Соединения и способы ингибирования экспрессии vcam-1 - Google Patents

Соединения и способы ингибирования экспрессии vcam-1

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Publication number
EA199901026A1
EA199901026A1 EA199901026A EA199901026A EA199901026A1 EA 199901026 A1 EA199901026 A1 EA 199901026A1 EA 199901026 A EA199901026 A EA 199901026A EA 199901026 A EA199901026 A EA 199901026A EA 199901026 A1 EA199901026 A1 EA 199901026A1
Authority
EA
Eurasian Patent Office
Prior art keywords
expression
methods
compounds
vcam
inhibiting
Prior art date
Application number
EA199901026A
Other languages
English (en)
Other versions
EA009370B1 (ru
Inventor
Патриция К. Самерс
Ли К. Хоонг
Чарльз К. Менг
Original Assignee
Атеродженикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атеродженикс, Инк. filed Critical Атеродженикс, Инк.
Priority to EA200500249A priority Critical patent/EA009987B1/ru
Publication of EA199901026A1 publication Critical patent/EA199901026A1/ru
Publication of EA009370B1 publication Critical patent/EA009370B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/21—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Настоящее изобретение относится к способам и композициям для ингибирования экспрессии VCAM-1, а в частности, для лечения заболеваний, опосредованных VCAM-1, включая сердечно-сосудистые и воспалительные заболевания.Отчет о международном поиске был опубликован после публикации международной заявки.
EA199901026A 1997-05-14 1998-05-14 Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1 EA009370B1 (ru)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA200500249A EA009987B1 (ru) 1997-05-14 1998-05-14 Производные пробукола для лечения заболеваний, опосредованных vcam-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4702097P 1997-05-14 1997-05-14
PCT/US1998/009781 WO1998051662A2 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1

Publications (2)

Publication Number Publication Date
EA199901026A1 true EA199901026A1 (ru) 2000-08-28
EA009370B1 EA009370B1 (ru) 2007-12-28

Family

ID=21946634

Family Applications (5)

Application Number Title Priority Date Filing Date
EA200500249A EA009987B1 (ru) 1997-05-14 1998-05-14 Производные пробукола для лечения заболеваний, опосредованных vcam-1
EA200800375A EA200800375A1 (ru) 1997-05-14 1998-05-14 Соединения и способы ингибирования экспрессии vcam-1
EA199901026A EA009370B1 (ru) 1997-05-14 1998-05-14 Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1
EA199901027A EA010183B1 (ru) 1997-05-14 1998-05-14 Сложный моноэфир янтарной кислоты и пробукола для лечения сердечно-сосудистых и воспалительных заболеваний
EA200601059A EA012847B1 (ru) 1997-05-14 1998-05-14 Сложные моноэфиры пробукола для лечения сердечно-сосудистых и воспалительных заболеваний, опосредованных vcam-1

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA200500249A EA009987B1 (ru) 1997-05-14 1998-05-14 Производные пробукола для лечения заболеваний, опосредованных vcam-1
EA200800375A EA200800375A1 (ru) 1997-05-14 1998-05-14 Соединения и способы ингибирования экспрессии vcam-1

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA199901027A EA010183B1 (ru) 1997-05-14 1998-05-14 Сложный моноэфир янтарной кислоты и пробукола для лечения сердечно-сосудистых и воспалительных заболеваний
EA200601059A EA012847B1 (ru) 1997-05-14 1998-05-14 Сложные моноэфиры пробукола для лечения сердечно-сосудистых и воспалительных заболеваний, опосредованных vcam-1

Country Status (26)

Country Link
US (9) US6147250A (ru)
EP (2) EP0981343B1 (ru)
JP (4) JP3930056B2 (ru)
KR (5) KR20010012504A (ru)
CN (7) CN100453530C (ru)
AT (3) ATE356113T1 (ru)
AU (2) AU747801C (ru)
BR (2) BR9809793A (ru)
CA (3) CA2428130A1 (ru)
CY (1) CY1107645T1 (ru)
CZ (4) CZ301183B6 (ru)
DE (3) DE69837295T2 (ru)
DK (2) DK1464639T3 (ru)
EA (5) EA009987B1 (ru)
ES (3) ES2241139T3 (ru)
HK (2) HK1024629A1 (ru)
HU (2) HUP0004592A3 (ru)
ID (2) ID23877A (ru)
IL (7) IL164568A0 (ru)
NO (3) NO327603B1 (ru)
NZ (2) NZ528906A (ru)
PL (2) PL194329B1 (ru)
PT (1) PT1464639E (ru)
SK (4) SK286674B6 (ru)
TR (2) TR199902802T2 (ru)
WO (2) WO1998051289A2 (ru)

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BR9809793A (pt) 2000-06-27
WO1998051289A2 (en) 1998-11-19
AU7485198A (en) 1998-12-08
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CN1263522A (zh) 2000-08-16
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