JPS52125170A - Pyridine derivatives - Google Patents
Pyridine derivativesInfo
- Publication number
- JPS52125170A JPS52125170A JP4144376A JP4144376A JPS52125170A JP S52125170 A JPS52125170 A JP S52125170A JP 4144376 A JP4144376 A JP 4144376A JP 4144376 A JP4144376 A JP 4144376A JP S52125170 A JPS52125170 A JP S52125170A
- Authority
- JP
- Japan
- Prior art keywords
- pyridine derivatives
- pyridine
- formula
- lower alkyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: Pyridine derivatives of formula I [Y is - O -,- S -, - N(R4)-; R1-2 are H, OH, lower alkyl; R3 is H, hydroxymethyl, radical of formula II; R4 is H, lower alkyl, aralkyl, aryl, allyl, cycloalkyl; n is 0 - 3; m is 0,1]; for example, 3-(3,5-di-t-butyl-4-hydroxybenzyloxylmethyl)pyridine.
COPYRIGHT: (C)1977,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4144376A JPS52125170A (en) | 1976-04-12 | 1976-04-12 | Pyridine derivatives |
FR7709451A FR2348201A1 (en) | 1976-04-12 | 1977-03-30 | NEW DRUGS FOR THE TREATMENT OF ISCHEMIC VASCULAR DISORDERS |
GB14443/77A GB1557622A (en) | 1976-04-12 | 1977-04-05 | 3 5 ditertiary butyl 4 hydroxaphenylpyridine compounds |
DE19772716125 DE2716125A1 (en) | 1976-04-12 | 1977-04-12 | 3,5-DI-TERT.-BUTYL-4-HYDROXYPHENYLPYRIDINE COMPOUNDS, METHOD FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
SE7704197A SE7704197L (en) | 1976-04-12 | 1977-04-12 | PYRIDINE ASSOCIATIONS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4144376A JPS52125170A (en) | 1976-04-12 | 1976-04-12 | Pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS52125170A true JPS52125170A (en) | 1977-10-20 |
JPS6126539B2 JPS6126539B2 (en) | 1986-06-20 |
Family
ID=12608501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4144376A Granted JPS52125170A (en) | 1976-04-12 | 1976-04-12 | Pyridine derivatives |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS52125170A (en) |
DE (1) | DE2716125A1 (en) |
FR (1) | FR2348201A1 (en) |
GB (1) | GB1557622A (en) |
SE (1) | SE7704197L (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0794439B2 (en) * | 1990-05-31 | 1995-10-11 | フアイザー・インコーポレイテツド | Method for producing substituted piperidine |
JP2006188525A (en) * | 1999-05-28 | 2006-07-20 | Abbott Lab | Cell proliferation inhibitor |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4246263A (en) * | 1979-10-15 | 1981-01-20 | Pfizer Inc. | Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions |
USRE31624E (en) * | 1979-11-26 | 1984-07-03 | Forsyth Dental Infirmary For Children | Method of treating inflammation |
US4244956A (en) * | 1979-11-26 | 1981-01-13 | Forsyth Dental Infirmary For Children | Method of treating inflammation |
US4563526A (en) * | 1980-09-19 | 1986-01-07 | Forsyth Dental Infirmary For Children | Substituted 2-(arylmethoxy) phenol compounds for the treatment of inflammation |
DE3216843C2 (en) * | 1982-05-05 | 1986-10-23 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | 3-Thiomethyl-pyridine derivatives, processes for their preparation and pharmaceuticals containing these compounds |
US5157053A (en) * | 1985-02-04 | 1992-10-20 | G. D. Searle & Co. | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders |
US4959364A (en) * | 1985-02-04 | 1990-09-25 | G. D. Searle & Co. | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides |
US5244899A (en) * | 1985-02-04 | 1993-09-14 | G. D. Searle And Co. | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders |
US5225444A (en) * | 1985-02-04 | 1993-07-06 | G. D. Searle & Co. | Disubstituted 4-hydroxyphenylthio anilides |
US5071876A (en) * | 1985-02-04 | 1991-12-10 | G. D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
EP0218782B1 (en) * | 1985-05-20 | 1990-05-16 | G.D. Searle & Co. | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds |
US5229421A (en) * | 1985-05-20 | 1993-07-20 | G. D. Searle & Co. | Methods and compositions for inhibiting lipoxygenase |
DK377487A (en) * | 1986-07-21 | 1988-01-22 | Otsuka Pharma Co Ltd | P-aminophenol |
DE3712752A1 (en) * | 1987-04-15 | 1988-11-03 | Hoechst Ag | HETEROCYCLIC NEOPHANAL ANALOG, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PEST CONTROL |
JPS63302851A (en) * | 1987-06-02 | 1988-12-09 | Nippon Medical Supply Corp | Blood bag for preserving platelet |
US5002967A (en) * | 1987-06-05 | 1991-03-26 | G. D. Searle & Co. | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase |
US4835189A (en) * | 1987-06-05 | 1989-05-30 | G. D. Searle & Co. | Phenolic thioalkylamides as inhibitors of 5-lipoxygenase |
JPH0620523Y2 (en) * | 1989-12-07 | 1994-06-01 | 川澄化学工業株式会社 | Medical container |
US5281623A (en) * | 1990-08-27 | 1994-01-25 | Eli Lilly And Company | Method for treating inflammation |
US5082854A (en) * | 1990-09-07 | 1992-01-21 | G. D. Searle & Co. | Method of stimulating superoxide generation |
US5189038A (en) * | 1990-09-07 | 1993-02-23 | G. D. Searle And Co. | Method of stimulating superoxide generation |
CA2088503A1 (en) * | 1990-09-07 | 1992-03-08 | Richard August Mueller | Phenolic thioetheramides as 5-lipoxygenase inhibitors |
US5254549A (en) * | 1991-12-19 | 1993-10-19 | Merz & Co. Gmbh & Co. | New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs |
LT3339B (en) | 1993-03-05 | 1995-07-25 | Merz & Co Gmbh & Co | New bht ether compounds and their use as hypolipidemic and antiatherosclerotic drugs |
US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
AU2006202461B2 (en) * | 1997-05-14 | 2009-12-03 | Atherogenics, Inc. | Compositions and methods for the inhibition of the expression of VCAM-1 |
EP1695959A1 (en) * | 1997-05-14 | 2006-08-30 | Atherogenics, Inc. | Compouds and methods for the inhibition of the expression of VCAM-1 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
ATE294158T1 (en) | 1997-05-14 | 2005-05-15 | Atherogenics Inc | A MONOETHER OF PROBUCOL AND METHODS OF INHIBITING VCAM-1 EXPRESSION |
EP1019034A2 (en) | 1997-07-01 | 2000-07-19 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
US7064139B2 (en) * | 2001-10-29 | 2006-06-20 | Uniroyal Chemical Company, Inc. | Method for treating retroviral infections |
WO2005102323A2 (en) | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
AU2008230861A1 (en) | 2007-03-26 | 2008-10-02 | Salutria Pharmaceuticals, Llc | Methods and compositions of derivatives of probucol for the treatment of diabetes |
CN104045552B (en) * | 2013-03-13 | 2019-06-11 | 江苏先声药业有限公司 | Medicinal compound as neuroprotective agent |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1010880A (en) * | 1972-08-16 | 1977-05-24 | Gustave K. Kohn | 3,5-dialkyl-4-hydroxybenzoic acid esters |
-
1976
- 1976-04-12 JP JP4144376A patent/JPS52125170A/en active Granted
-
1977
- 1977-03-30 FR FR7709451A patent/FR2348201A1/en not_active Withdrawn
- 1977-04-05 GB GB14443/77A patent/GB1557622A/en not_active Expired
- 1977-04-12 DE DE19772716125 patent/DE2716125A1/en active Pending
- 1977-04-12 SE SE7704197A patent/SE7704197L/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0794439B2 (en) * | 1990-05-31 | 1995-10-11 | フアイザー・インコーポレイテツド | Method for producing substituted piperidine |
JP2006188525A (en) * | 1999-05-28 | 2006-07-20 | Abbott Lab | Cell proliferation inhibitor |
Also Published As
Publication number | Publication date |
---|---|
GB1557622A (en) | 1979-12-12 |
DE2716125A1 (en) | 1977-10-27 |
FR2348201A1 (en) | 1977-11-10 |
SE7704197L (en) | 1977-10-13 |
JPS6126539B2 (en) | 1986-06-20 |
Similar Documents
Publication | Publication Date | Title |
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JPS52125170A (en) | Pyridine derivatives | |
JPS51146466A (en) | A process for preparing 1,3-dithiolan-2- iridenmalonate derivatives an d their use | |
JPS5271492A (en) | Synthesis of 9-substituted-2-substituted thioadenines | |
JPS5368753A (en) | Thiaprostanoic acid derivatives and their preparation | |
JPS52125171A (en) | Preparation of pyridine derivatives | |
JPS51128976A (en) | Process for preparing carbostyril derivatives | |
JPS51133277A (en) | A process for preparing novel carbostyril derivatives | |
JPS5233627A (en) | Preparation of novel o,o-dialkyl-o-(n-alkoxy-halogeno-acycimidoyl) pho sphates or thionophosphates | |
JPS51141880A (en) | Process for preparing carbostyril derivatives | |
JPS51128979A (en) | Process for preparing carbostyril derivatives | |
JPS525798A (en) | Preparation of pyridopyridazine derivatives | |
JPS5416466A (en) | Novel 3-hydroxypyrrolldine-3-carboxylic derivative | |
JPS5262295A (en) | Preparation of n1-oxy-2-thioadenosines | |
JPS51146474A (en) | Process for preparing piperidylbenzimidazole derivatives | |
JPS53127490A (en) | Novel nitrogen-containing heterocyclic compound | |
JPS51133279A (en) | A process for preparing novel carbostyril derivatives | |
JPS5257145A (en) | Process for preparing novel alkyl 16_alkyl-20-alkoxyprostadienate deri vatives | |
JPS51113879A (en) | Method for preparing carbostyryl derivatives | |
JPS51133280A (en) | A process for preparing 3,4- dihydrocarbostyril derivatives | |
JPS5283671A (en) | 3-substituted-3-alkoxycarbonyl-2-piperidon | |
JPS5427560A (en) | Novel imidazole derivatives | |
JPS5210277A (en) | A process for preparing 3-substituted-3- alkoxycarbonyl-2-piperidone | |
JPS51133278A (en) | A process for preparing novel carbostyril derivatives | |
JPS51136677A (en) | Process for preparation of carbostyril derivatives | |
JPS5414987A (en) | Novel s-triazine compounds and its preparation |