AR009358A1 - Compuesto espirociclico inhibidor de la metaloproteasa - Google Patents
Compuesto espirociclico inhibidor de la metaloproteasaInfo
- Publication number
- AR009358A1 AR009358A1 ARP970103899A ARP970103899A AR009358A1 AR 009358 A1 AR009358 A1 AR 009358A1 AR P970103899 A ARP970103899 A AR P970103899A AR P970103899 A ARP970103899 A AR P970103899A AR 009358 A1 AR009358 A1 AR 009358A1
- Authority
- AR
- Argentina
- Prior art keywords
- metalloprotease inhibitor
- spirocyclic compound
- compounds
- pharmaceutical compositions
- metalloprotease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/16—Otologicals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
Abstract
Compuestos de la formula (I), segun se describe en las reivindicaciones, o un isomero, diasteromero o enantiomero optico de los mismos, o una salfarmacéuticamente aceptable, o una amida biohidrolizable, un éster o una imida de los mismos utiles como inhibidores de las metaloproteasas. También sepublican las composiciones y los métodos farmacéuticos para el tratamiento de enfermedades, desordenes y condiciones caracterizadas por la actividadmetaloproteasa usando estos compuestos o las composiciones farmacéuticas que las contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2476696P | 1996-08-28 | 1996-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009358A1 true AR009358A1 (es) | 2000-04-12 |
Family
ID=21822299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103899A AR009358A1 (es) | 1996-08-28 | 1997-08-27 | Compuesto espirociclico inhibidor de la metaloproteasa |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6015912A (es) |
| EP (1) | EP0927183B1 (es) |
| JP (2) | JP3495376B2 (es) |
| KR (1) | KR100326611B1 (es) |
| CN (1) | CN1105723C (es) |
| AR (1) | AR009358A1 (es) |
| AT (1) | ATE272062T1 (es) |
| AU (1) | AU736238B2 (es) |
| BR (1) | BR9713178A (es) |
| CA (1) | CA2264044A1 (es) |
| CO (1) | CO4900045A1 (es) |
| CZ (1) | CZ63799A3 (es) |
| DE (1) | DE69730033T2 (es) |
| DK (1) | DK0927183T3 (es) |
| ES (1) | ES2225983T3 (es) |
| HK (1) | HK1021184A1 (es) |
| HU (1) | HUP9904694A3 (es) |
| ID (1) | ID19418A (es) |
| IL (1) | IL128667A (es) |
| NO (1) | NO315373B1 (es) |
| NZ (1) | NZ334257A (es) |
| PE (1) | PE107798A1 (es) |
| PL (1) | PL331920A1 (es) |
| PT (1) | PT927183E (es) |
| RU (1) | RU2203274C2 (es) |
| SK (1) | SK284041B6 (es) |
| TR (1) | TR199900429T2 (es) |
| TW (1) | TW581761B (es) |
| WO (1) | WO1998008850A1 (es) |
| ZA (1) | ZA977699B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030206874A1 (en) * | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
| HUP0004595A3 (en) | 1997-07-31 | 2001-12-28 | Procter & Gamble | Acyclic metalloprotease inhibitors |
| US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| HUP0101176A3 (en) | 1998-02-04 | 2002-06-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them |
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US6197974B1 (en) * | 1998-10-26 | 2001-03-06 | Abbott Laboratories | Enantioselective synthesis of 3-aminopyrrolidines |
| JP2002538136A (ja) | 1999-03-03 | 2002-11-12 | ザ プロクター アンド ギャンブル カンパニー | アルケニルおよびアルキニル含有メタロプロテアーゼ阻害剤 |
| HUP0201714A3 (en) | 1999-03-03 | 2003-05-28 | Procter & Gamble | Substituted heterocyclic compounds and pharmaceutical compositions containing them |
| MXPA03000043A (es) * | 2000-06-30 | 2003-10-15 | Procter & Gamble | Promocion de la salud en todo el cuerpo. |
| DE60134855D1 (de) * | 2000-06-30 | 2008-08-28 | Procter & Gamble | Orale zubereitungen, die antimikrobielle wirkstoffe enthalten zur prävention von systemischen erkrankungen |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| FR2818643B1 (fr) * | 2000-12-22 | 2003-02-07 | Servier Lab | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent |
| WO2003016248A2 (en) | 2001-08-17 | 2003-02-27 | Bristol-Myers Squibb Company Patent Department | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace) |
| RU2379303C2 (ru) | 2003-04-24 | 2010-01-20 | Инсайт Корпорейшн | Производные азаспироалканов в качестве ингибиторов металлопротеаз |
| DE102004004974A1 (de) * | 2004-01-31 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen |
| SG172661A1 (en) * | 2006-06-01 | 2011-07-28 | Sanofi Aventis | Spirocyclic nitriles as protease inhibitors |
| US8575208B2 (en) * | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| PL2114951T3 (pl) * | 2007-02-28 | 2014-10-31 | Leo Pharma As | Nowe inhibitory fosfodiesterazy |
| SG178952A1 (en) | 2009-09-04 | 2012-04-27 | Glaxosmithkline Llc | Chemical compounds |
| WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
| RU2523284C9 (ru) * | 2012-05-31 | 2014-10-10 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Способ модификации макролидного антибиотика олигомицина а с помощью реакции [3+2]-диполярного циклоприсоединения азида и алкинов. 33-дезокис-33-(триазол-1-ил)-олигомицины а и их биологическая активность |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| AR110150A1 (es) * | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
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| US4521537A (en) * | 1982-08-20 | 1985-06-04 | Hoechst-Roussel Pharmaceuticals Incorporated | Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents |
| US4555579A (en) * | 1983-03-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors |
| US4709046A (en) * | 1983-05-09 | 1987-11-24 | E. R. Squibb & Sons, Inc. | Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds |
| EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
| GB8601368D0 (en) * | 1986-01-21 | 1986-02-26 | Ici America Inc | Hydroxamic acids |
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US4847384A (en) * | 1987-03-12 | 1989-07-11 | Sandoz Pharm. Corp. | Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor |
| GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
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| DD298639A5 (de) * | 1989-12-21 | 1992-03-05 | Institut Fuer Chemische Technologie,De | Verfahren zur herstellung von sulfobetainsubstituierten alpha-sulfonyl-carbonsaeuren aus diallylammoniumsalzen |
| DE4011172A1 (de) * | 1990-04-06 | 1991-10-10 | Degussa | Verbindungen zur bekaempfung von pflanzenkrankheiten |
| US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
| GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
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| DE4127842A1 (de) * | 1991-08-22 | 1993-02-25 | Rhone Poulenc Rorer Gmbh | 5-((omega)-arylalky)-2-thienyl alkansaeuren, ihre salze und/oder ihre derivate |
| JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| FR2689509B1 (fr) * | 1992-04-01 | 1994-06-03 | Adir | Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE69309047T2 (de) * | 1992-04-07 | 1997-09-11 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
| WO1993021942A2 (en) * | 1992-05-01 | 1993-11-11 | British Biotech Pharmaceuticals Limited | Use of mmp inhibitors |
| AU666727B2 (en) * | 1992-06-25 | 1996-02-22 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives |
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
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| CA2193691A1 (en) * | 1994-06-22 | 1995-12-28 | Andrew Miller | Metalloproteinase inhibitors |
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1997
- 1997-08-22 SK SK255-99A patent/SK284041B6/sk unknown
- 1997-08-22 PT PT97939445T patent/PT927183E/pt unknown
- 1997-08-22 IL IL12866797A patent/IL128667A/en not_active IP Right Cessation
- 1997-08-22 KR KR1019997001652A patent/KR100326611B1/ko not_active IP Right Cessation
- 1997-08-22 AU AU41532/97A patent/AU736238B2/en not_active Ceased
- 1997-08-22 EP EP97939445A patent/EP0927183B1/en not_active Expired - Lifetime
- 1997-08-22 DE DE69730033T patent/DE69730033T2/de not_active Expired - Fee Related
- 1997-08-22 CN CN97197542A patent/CN1105723C/zh not_active Expired - Fee Related
- 1997-08-22 ES ES97939445T patent/ES2225983T3/es not_active Expired - Lifetime
- 1997-08-22 RU RU99106587/04A patent/RU2203274C2/ru not_active IP Right Cessation
- 1997-08-22 NZ NZ334257A patent/NZ334257A/xx unknown
- 1997-08-22 DK DK97939445T patent/DK0927183T3/da active
- 1997-08-22 CZ CZ99637A patent/CZ63799A3/cs unknown
- 1997-08-22 CA CA002264044A patent/CA2264044A1/en not_active Abandoned
- 1997-08-22 HU HU9904694A patent/HUP9904694A3/hu unknown
- 1997-08-22 AT AT97939445T patent/ATE272062T1/de not_active IP Right Cessation
- 1997-08-22 BR BR9713178-4A patent/BR9713178A/pt not_active IP Right Cessation
- 1997-08-22 TR TR1999/00429T patent/TR199900429T2/xx unknown
- 1997-08-22 PL PL97331920A patent/PL331920A1/xx unknown
- 1997-08-22 WO PCT/US1997/014557 patent/WO1998008850A1/en not_active Application Discontinuation
- 1997-08-22 JP JP51171798A patent/JP3495376B2/ja not_active Expired - Fee Related
- 1997-08-26 US US08/918,328 patent/US6015912A/en not_active Expired - Fee Related
- 1997-08-27 CO CO97049506A patent/CO4900045A1/es unknown
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- 1997-08-28 ID IDP972995A patent/ID19418A/id unknown
- 1997-08-28 PE PE1997000769A patent/PE107798A1/es not_active Application Discontinuation
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1998
- 1998-02-03 TW TW087101299A patent/TW581761B/zh not_active IP Right Cessation
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1999
- 1999-02-23 NO NO19990856A patent/NO315373B1/no unknown
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2000
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2003
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