SK284041B6 - Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie - Google Patents
Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie Download PDFInfo
- Publication number
- SK284041B6 SK284041B6 SK255-99A SK25599A SK284041B6 SK 284041 B6 SK284041 B6 SK 284041B6 SK 25599 A SK25599 A SK 25599A SK 284041 B6 SK284041 B6 SK 284041B6
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- SK
- Slovakia
- Prior art keywords
- mmol
- mixture
- compounds
- alkyl
- substituted
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2476696P | 1996-08-28 | 1996-08-28 | |
| PCT/US1997/014557 WO1998008850A1 (en) | 1996-08-28 | 1997-08-22 | Spirocyclic metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK25599A3 SK25599A3 (en) | 2000-05-16 |
| SK284041B6 true SK284041B6 (sk) | 2004-08-03 |
Family
ID=21822299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK255-99A SK284041B6 (sk) | 1996-08-28 | 1997-08-22 | Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6015912A (es) |
| EP (1) | EP0927183B1 (es) |
| JP (2) | JP3495376B2 (es) |
| KR (1) | KR100326611B1 (es) |
| CN (1) | CN1105723C (es) |
| AR (1) | AR009358A1 (es) |
| AT (1) | ATE272062T1 (es) |
| AU (1) | AU736238B2 (es) |
| BR (1) | BR9713178A (es) |
| CA (1) | CA2264044A1 (es) |
| CO (1) | CO4900045A1 (es) |
| CZ (1) | CZ63799A3 (es) |
| DE (1) | DE69730033T2 (es) |
| DK (1) | DK0927183T3 (es) |
| ES (1) | ES2225983T3 (es) |
| HK (1) | HK1021184A1 (es) |
| HU (1) | HUP9904694A3 (es) |
| ID (1) | ID19418A (es) |
| IL (1) | IL128667A (es) |
| NO (1) | NO315373B1 (es) |
| NZ (1) | NZ334257A (es) |
| PE (1) | PE107798A1 (es) |
| PL (1) | PL331920A1 (es) |
| PT (1) | PT927183E (es) |
| RU (1) | RU2203274C2 (es) |
| SK (1) | SK284041B6 (es) |
| TR (1) | TR199900429T2 (es) |
| TW (1) | TW581761B (es) |
| WO (1) | WO1998008850A1 (es) |
| ZA (1) | ZA977699B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030206874A1 (en) * | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
| NZ503945A (en) | 1997-07-31 | 2002-11-26 | Procter & Gamble | Metalloprotease-inhibiting amide derivatives |
| HUP0101176A3 (en) | 1998-02-04 | 2002-06-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them |
| US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US6197974B1 (en) * | 1998-10-26 | 2001-03-06 | Abbott Laboratories | Enantioselective synthesis of 3-aminopyrrolidines |
| MXPA01008857A (es) | 1999-03-03 | 2002-07-02 | Procter & Gamble | Inhibidores de metaloproteasa dihetero sustituidos. |
| CN1349498A (zh) | 1999-03-03 | 2002-05-15 | 宝洁公司 | 含有链烯基和炔基的金属蛋白酶抑制剂 |
| DE60134855D1 (de) * | 2000-06-30 | 2008-08-28 | Procter & Gamble | Orale zubereitungen, die antimikrobielle wirkstoffe enthalten zur prävention von systemischen erkrankungen |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| MXPA03000043A (es) * | 2000-06-30 | 2003-10-15 | Procter & Gamble | Promocion de la salud en todo el cuerpo. |
| FR2818643B1 (fr) * | 2000-12-22 | 2003-02-07 | Servier Lab | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent |
| WO2003016248A2 (en) | 2001-08-17 | 2003-02-27 | Bristol-Myers Squibb Company Patent Department | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace) |
| HUP0501182A3 (en) | 2003-04-24 | 2011-08-29 | Incyte Corp | Aza spiro alkane derivatives as inhibitors of metallproteases and pharmaceutical compositions containing them |
| DE102004004974A1 (de) * | 2004-01-31 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen |
| DK2032535T3 (da) * | 2006-06-01 | 2012-11-05 | Sanofi Sa | Spiro-cycliske nitriler som protease-inhibitorer |
| CN101903392A (zh) * | 2007-02-27 | 2010-12-01 | 弗特克斯药品有限公司 | 丝氨酸蛋白酶的抑制剂 |
| NZ578804A (en) * | 2007-02-28 | 2012-04-27 | Leo Pharma As | Spirocyclic phosphodiesterase inhibitors |
| EP2473056A4 (en) | 2009-09-04 | 2013-02-13 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
| WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
| RU2523284C9 (ru) * | 2012-05-31 | 2014-10-10 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Способ модификации макролидного антибиотика олигомицина а с помощью реакции [3+2]-диполярного циклоприсоединения азида и алкинов. 33-дезокис-33-(триазол-1-ил)-олигомицины а и их биологическая активность |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| AR110150A1 (es) * | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6818875A (es) * | 1968-01-24 | 1969-07-28 | ||
| US4521537A (en) * | 1982-08-20 | 1985-06-04 | Hoechst-Roussel Pharmaceuticals Incorporated | Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents |
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| US4709046A (en) * | 1983-05-09 | 1987-11-24 | E. R. Squibb & Sons, Inc. | Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds |
| EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
| GB8601368D0 (en) * | 1986-01-21 | 1986-02-26 | Ici America Inc | Hydroxamic acids |
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| DD298639A5 (de) * | 1989-12-21 | 1992-03-05 | Institut Fuer Chemische Technologie,De | Verfahren zur herstellung von sulfobetainsubstituierten alpha-sulfonyl-carbonsaeuren aus diallylammoniumsalzen |
| DE4011172A1 (de) * | 1990-04-06 | 1991-10-10 | Degussa | Verbindungen zur bekaempfung von pflanzenkrankheiten |
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| NZ288298A (en) * | 1994-06-22 | 1998-12-23 | British Biotech Pharm | Hydroxamic acid and carboxylic acid derivatives; medicaments containing such derivatives that are metalloproteinase inhibitors |
-
1997
- 1997-08-22 DK DK97939445T patent/DK0927183T3/da active
- 1997-08-22 AU AU41532/97A patent/AU736238B2/en not_active Ceased
- 1997-08-22 HU HU9904694A patent/HUP9904694A3/hu unknown
- 1997-08-22 BR BR9713178-4A patent/BR9713178A/pt not_active IP Right Cessation
- 1997-08-22 JP JP51171798A patent/JP3495376B2/ja not_active Expired - Fee Related
- 1997-08-22 CN CN97197542A patent/CN1105723C/zh not_active Expired - Fee Related
- 1997-08-22 AT AT97939445T patent/ATE272062T1/de not_active IP Right Cessation
- 1997-08-22 RU RU99106587/04A patent/RU2203274C2/ru not_active IP Right Cessation
- 1997-08-22 PL PL97331920A patent/PL331920A1/xx unknown
- 1997-08-22 EP EP97939445A patent/EP0927183B1/en not_active Expired - Lifetime
- 1997-08-22 KR KR1019997001652A patent/KR100326611B1/ko not_active IP Right Cessation
- 1997-08-22 CA CA002264044A patent/CA2264044A1/en not_active Abandoned
- 1997-08-22 PT PT97939445T patent/PT927183E/pt unknown
- 1997-08-22 ES ES97939445T patent/ES2225983T3/es not_active Expired - Lifetime
- 1997-08-22 DE DE69730033T patent/DE69730033T2/de not_active Expired - Fee Related
- 1997-08-22 TR TR1999/00429T patent/TR199900429T2/xx unknown
- 1997-08-22 WO PCT/US1997/014557 patent/WO1998008850A1/en not_active Application Discontinuation
- 1997-08-22 SK SK255-99A patent/SK284041B6/sk unknown
- 1997-08-22 NZ NZ334257A patent/NZ334257A/xx unknown
- 1997-08-22 IL IL12866797A patent/IL128667A/en not_active IP Right Cessation
- 1997-08-22 CZ CZ99637A patent/CZ63799A3/cs unknown
- 1997-08-26 US US08/918,328 patent/US6015912A/en not_active Expired - Fee Related
- 1997-08-27 ZA ZA9707699A patent/ZA977699B/xx unknown
- 1997-08-27 CO CO97049506A patent/CO4900045A1/es unknown
- 1997-08-27 AR ARP970103899A patent/AR009358A1/es unknown
- 1997-08-28 ID IDP972995A patent/ID19418A/id unknown
- 1997-08-28 PE PE1997000769A patent/PE107798A1/es not_active Application Discontinuation
-
1998
- 1998-02-03 TW TW087101299A patent/TW581761B/zh not_active IP Right Cessation
-
1999
- 1999-02-23 NO NO19990856A patent/NO315373B1/no unknown
-
2000
- 2000-01-06 HK HK00100094A patent/HK1021184A1/xx not_active IP Right Cessation
-
2003
- 2003-08-13 JP JP2003292947A patent/JP2004002470A/ja not_active Withdrawn
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