BR112012007979A2 - moduladores de gpr40 de pirrolidina - Google Patents

moduladores de gpr40 de pirrolidina

Info

Publication number
BR112012007979A2
BR112012007979A2 BR112012007979A BR112012007979A BR112012007979A2 BR 112012007979 A2 BR112012007979 A2 BR 112012007979A2 BR 112012007979 A BR112012007979 A BR 112012007979A BR 112012007979 A BR112012007979 A BR 112012007979A BR 112012007979 A2 BR112012007979 A2 BR 112012007979A2
Authority
BR
Brazil
Prior art keywords
gpr40 modulators
pyrrolidine
modulators
pyrrolidine gpr40
compounds
Prior art date
Application number
BR112012007979A
Other languages
English (en)
Inventor
Bruce A Ellsworth
Elizabeth A Jurica
William R Ewing
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112012007979A2 publication Critical patent/BR112012007979A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

moduladores de gpr40 de pirrolidina a presente de invenção refere-se a compostos de fórmula (i): ou um estereoisônero, ou um sal farmaceuticamente aceitável dos mesmos , em que todas as variáveis são como aqui definidas. estes compostos são moduladores do receptor acoplado a proteína ggpr40 que podem ser usados como medicamentos.
BR112012007979A 2009-10-06 2010-10-05 moduladores de gpr40 de pirrolidina BR112012007979A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24889609P 2009-10-06 2009-10-06
PCT/US2010/051389 WO2011044073A1 (en) 2009-10-06 2010-10-05 Pyrrolidine gpr40 modulators

Publications (1)

Publication Number Publication Date
BR112012007979A2 true BR112012007979A2 (pt) 2016-03-29

Family

ID=43242297

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012007979A BR112012007979A2 (pt) 2009-10-06 2010-10-05 moduladores de gpr40 de pirrolidina

Country Status (13)

Country Link
US (1) US8288404B2 (pt)
EP (1) EP2486005B1 (pt)
JP (1) JP2013506714A (pt)
KR (1) KR20120104534A (pt)
CN (1) CN102639495A (pt)
AR (1) AR078542A1 (pt)
AU (1) AU2010303670A1 (pt)
BR (1) BR112012007979A2 (pt)
CA (1) CA2777041A1 (pt)
MX (1) MX2012003389A (pt)
RU (1) RU2012118504A (pt)
TW (1) TW201116510A (pt)
WO (1) WO2011044073A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011332198A1 (en) * 2010-11-24 2013-07-11 Allergan, Inc. Modulators of S1P receptors
AU2013290100A1 (en) 2012-07-11 2015-01-29 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
KR101942752B1 (ko) * 2012-11-05 2019-01-28 주식회사 엘지화학 Ｇｐｒ120 효능제로서의 티오아릴 유도체
US9133163B2 (en) 2012-11-16 2015-09-15 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
US9656963B2 (en) * 2012-11-16 2017-05-23 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
ES2606197T3 (es) * 2012-11-16 2017-03-23 Bristol-Myers Squibb Company Moduladores pirrolidina de GPR40
SG11201503556PA (en) 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators
WO2014203217A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
CA2914415A1 (en) 2013-06-24 2014-12-31 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
EA201690888A1 (ru) 2013-11-14 2016-10-31 Кадила Хелзкэр Лимитед Новые гетероциклические соединения
US11104668B2 (en) 2013-12-13 2021-08-31 Hoffmann-La Roche Inc. Inhibitors of bruton's tyrosine kinase
TN2016000444A1 (en) * 2014-05-07 2018-04-04 Bristol Myers Squibb Co Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes.
SG11201609167RA (en) * 2014-05-07 2016-12-29 Bristol Myers Squibb Co Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes
EP3140294A1 (en) * 2014-05-07 2017-03-15 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
CN110023298B (zh) * 2016-11-24 2022-12-16 浙江迈同生物医药有限公司 异柠檬酸脱氢酶(idh)抑制剂
PL3752501T3 (pl) 2018-02-13 2023-08-21 Gilead Sciences, Inc. Inhibitory pd-1/pd-l1
WO2019226213A2 (en) 2018-03-08 2019-11-28 Incyte Corporation AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
EP3781556A1 (en) 2018-04-19 2021-02-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN110041269A (zh) * 2019-05-16 2019-07-23 海门瑞一医药科技有限公司 一种2-氯-5-羟基嘧啶的制备方法
CN111253223A (zh) * 2020-03-20 2020-06-09 重庆医科大学 一类大位阻三芳基甲烷衍生物及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579681B2 (ja) 2002-07-09 2010-11-10 ブリストル−マイヤーズ スクイブ カンパニー 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法
DE10309929B4 (de) * 2003-03-07 2006-02-23 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
US7501440B2 (en) 2003-03-07 2009-03-10 Sanofi-Aventis Deutschland Gmbh Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
AU2007293028B2 (en) 2006-09-07 2012-05-31 Amgen Inc. Heterocyclic GPR40 modulators

Also Published As

Publication number Publication date
RU2012118504A (ru) 2013-11-20
US8288404B2 (en) 2012-10-16
EP2486005A1 (en) 2012-08-15
KR20120104534A (ko) 2012-09-21
EP2486005B1 (en) 2014-06-18
JP2013506714A (ja) 2013-02-28
CN102639495A (zh) 2012-08-15
TW201116510A (en) 2011-05-16
WO2011044073A1 (en) 2011-04-14
CA2777041A1 (en) 2011-04-14
US20110082165A1 (en) 2011-04-07
AU2010303670A1 (en) 2012-03-29
AR078542A1 (es) 2011-11-16
MX2012003389A (es) 2012-04-10

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]