ATE524449T1 - Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen - Google Patents
Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenenInfo
- Publication number
- ATE524449T1 ATE524449T1 AT04785719T AT04785719T ATE524449T1 AT E524449 T1 ATE524449 T1 AT E524449T1 AT 04785719 T AT04785719 T AT 04785719T AT 04785719 T AT04785719 T AT 04785719T AT E524449 T1 ATE524449 T1 AT E524449T1
- Authority
- AT
- Austria
- Prior art keywords
- viii
- formula
- preparation
- tetraaza
- iib
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 abstract 8
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000005580 one pot reaction Methods 0.000 abstract 3
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 abstract 2
- 101100294102 Caenorhabditis elegans nhr-2 gene Proteins 0.000 abstract 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960001124 trientine Drugs 0.000 abstract 2
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- -1 halo compound Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0350217A FR2856063B1 (fr) | 2003-06-13 | 2003-06-13 | Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises |
| PCT/FR2004/050213 WO2005000823A1 (fr) | 2003-06-13 | 2004-06-04 | Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, du cyclene, et de cyclenes fonctionnalises |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524449T1 true ATE524449T1 (de) | 2011-09-15 |
Family
ID=33484719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04785719T ATE524449T1 (de) | 2003-06-13 | 2004-06-04 | Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7659393B2 (de) |
| EP (1) | EP1644344B1 (de) |
| JP (1) | JP2006527241A (de) |
| AT (1) | ATE524449T1 (de) |
| CA (1) | CA2529332A1 (de) |
| FR (1) | FR2856063B1 (de) |
| WO (1) | WO2005000823A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2982611B1 (fr) | 2011-11-16 | 2014-01-03 | Univ Bretagne Occidentale | Procedes de preparation de composes tetraazacycloalcanes fonctionnels a l'aide d'un compose cyclique bisaminal particulier. |
| FR3072093A1 (fr) | 2017-10-11 | 2019-04-12 | Universite Paris-Sud | Cryptands a base de calix[4]arenes associes a un macrocycle azote et leur utilisation pour l'extraction selective de metaux strategiques |
| CN110698419A (zh) * | 2019-09-26 | 2020-01-17 | 广州康瑞泰药业有限公司 | 一种轮环藤宁的制备方法 |
| CN113072514B (zh) * | 2020-01-06 | 2023-09-01 | 联化科技股份有限公司 | 轮环藤宁及其中间体的制备方法 |
| RU2749722C1 (ru) * | 2020-07-15 | 2021-06-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Уфимский государственный нефтяной технический университет" | Способ получения четвертичной аммониевой соли, обладающей противоопухолевым действием |
| CN113956262B (zh) * | 2021-10-18 | 2023-03-07 | 苏州百灵威超精细材料有限公司 | 一种四氮杂环烷类化合物及其中间体的合成方法 |
| CN113999255A (zh) * | 2021-11-11 | 2022-02-01 | 中国科学院成都有机化学有限公司 | 多元稠杂环类化合物及其制备方法 |
| CN115785013A (zh) * | 2022-11-17 | 2023-03-14 | 安庆朗坤药业有限公司 | 一种轮环藤宁的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0661279T3 (da) * | 1993-12-30 | 2001-07-16 | Guerbet Sa | Polyaminiserede ligander, metalkomplekser, fremgangsmåde til deres fremstilling og diagnostiske og terapeutiske anvendelser |
| GB9504922D0 (en) * | 1995-03-10 | 1995-04-26 | Nycomed As | Process |
| IT1284046B1 (it) * | 1996-06-21 | 1998-05-08 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
| DE19652386A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden |
| CA2348893A1 (en) * | 1998-11-30 | 2000-06-08 | The Procter & Gamble Company | Process for preparing cross-bridged tetraaza macrocycles |
| US6656450B2 (en) * | 2000-07-17 | 2003-12-02 | California Institute Of Technology, Inc. | Macrocyclic magnetic resonance imaging contrast agents |
| WO2002059122A1 (en) * | 2001-01-24 | 2002-08-01 | Auckland Uniservices Limited | ANTI-CANCER 2,3-DIHYDRO-1H-PYRROLO[3,2-f]QUINOLINE COMPLEXES OF COBALT AND CHROMIUM |
| FR2830253B1 (fr) * | 2001-09-28 | 2005-02-04 | Air Liquide | Nouveau procede de preparation de macrocycles azotes c-fonctionnalises et nouveaux intermediaires obtenus |
-
2003
- 2003-06-13 FR FR0350217A patent/FR2856063B1/fr not_active Expired - Lifetime
-
2004
- 2004-06-04 AT AT04785719T patent/ATE524449T1/de not_active IP Right Cessation
- 2004-06-04 WO PCT/FR2004/050213 patent/WO2005000823A1/fr not_active Ceased
- 2004-06-04 US US10/560,162 patent/US7659393B2/en not_active Expired - Fee Related
- 2004-06-04 CA CA002529332A patent/CA2529332A1/fr not_active Abandoned
- 2004-06-04 EP EP04785719A patent/EP1644344B1/de not_active Expired - Lifetime
- 2004-06-04 JP JP2006516343A patent/JP2006527241A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1644344B1 (de) | 2011-09-14 |
| CA2529332A1 (fr) | 2005-01-06 |
| FR2856063A1 (fr) | 2004-12-17 |
| FR2856063B1 (fr) | 2005-10-07 |
| EP1644344A1 (de) | 2006-04-12 |
| WO2005000823A1 (fr) | 2005-01-06 |
| US20060217548A1 (en) | 2006-09-28 |
| JP2006527241A (ja) | 2006-11-30 |
| US7659393B2 (en) | 2010-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |