CR9545A - Metodos para sintetizar derivados de 6-alquilaminoquinolina - Google Patents
Metodos para sintetizar derivados de 6-alquilaminoquinolinaInfo
- Publication number
- CR9545A CR9545A CR9545A CR9545A CR9545A CR 9545 A CR9545 A CR 9545A CR 9545 A CR9545 A CR 9545A CR 9545 A CR9545 A CR 9545A CR 9545 A CR9545 A CR 9545A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- alquilaminoquinolina
- synthesizing derivatives
- directed
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion esta dirigida a un metodo para sintetizar compuestos de Formula (I), en donde X, Z, V, R1, R3, R4, G2, n, x, y, yz son como se define aqui. Esta invencion tambien incluye un metodo para preparar compuestos de acido de Formula (VII), en donde R es H, y R4, x, y, yz son como se define aqui y PG es un grupo protector. Esta invencion esta tambien dirigida a (E) N-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(metilamino)-2-butenamida, composiciones que contienen estos metodos para utilizar en el tratamiento del cancer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68504005P | 2005-05-25 | 2005-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9545A true CR9545A (es) | 2008-01-10 |
Family
ID=36794434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9545A CR9545A (es) | 2005-05-25 | 2007-11-23 | Metodos para sintetizar derivados de 6-alquilaminoquinolina |
Country Status (20)
Country | Link |
---|---|
US (1) | US20060270670A1 (es) |
EP (1) | EP1883630A2 (es) |
JP (1) | JP2008542266A (es) |
KR (1) | KR20080016604A (es) |
CN (1) | CN101180273A (es) |
AR (1) | AR054192A1 (es) |
AU (1) | AU2006249596A1 (es) |
BR (1) | BRPI0610142A2 (es) |
CA (1) | CA2608589A1 (es) |
CR (1) | CR9545A (es) |
GT (1) | GT200600215A (es) |
IL (1) | IL187301A0 (es) |
MX (1) | MX2007014774A (es) |
NO (1) | NO20075726L (es) |
PA (1) | PA8676301A1 (es) |
PE (1) | PE20070007A1 (es) |
RU (1) | RU2007140957A (es) |
TW (1) | TW200716556A (es) |
WO (1) | WO2006127203A2 (es) |
ZA (1) | ZA200710143B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2580108T3 (es) | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
WO2007008942A2 (en) * | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases |
JP5235887B2 (ja) | 2006-09-20 | 2013-07-10 | アエリー ファーマシューティカルズ インコーポレイテッド | Rhoキナーゼ阻害剤 |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
CA2929545C (en) | 2009-05-01 | 2019-04-09 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US8779192B2 (en) | 2009-05-14 | 2014-07-15 | Kolon Life Science, Inc. | Process of preparing an alkylamine derivative |
ES2624845T3 (es) | 2010-09-29 | 2017-07-17 | Intervet International B.V. | Compuestos de N-heteroarilo con unidad de puente cíclico para el tratamiento de enfermedades parasitarias |
AR083200A1 (es) | 2010-09-29 | 2013-02-06 | Intervet Int Bv | Compuestos de n-heteroarilo |
CN102649778A (zh) * | 2011-02-23 | 2012-08-29 | 苏州波锐生物医药科技有限公司 | 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
CN104203242B (zh) * | 2012-04-04 | 2017-03-15 | 杭州德润玉成生物科技有限公司 | 取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂 |
PL3811943T3 (pl) | 2013-03-15 | 2023-06-12 | Aerie Pharmaceuticals, Inc. | Związek do stosowania w leczeniu zaburzeń oczu |
TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
CA3005707C (en) | 2015-11-17 | 2023-11-21 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US10793548B2 (en) * | 2016-04-28 | 2020-10-06 | Jiangsu Hengrui Medicine Co., Ltd. | Method for preparing tyrosine kinase inhibitor and derivative thereof |
US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
AU4545201A (en) * | 2000-03-13 | 2001-09-24 | American Cyanamid Co | Method of treating or inhibiting colonic polyps |
UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
AU2003217323A1 (en) * | 2002-02-05 | 2003-09-02 | Wyeth | Process for the synthesis of n-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids |
CL2004000016A1 (es) * | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
JP2007502819A (ja) * | 2003-08-19 | 2007-02-15 | ワイス・ホールディングズ・コーポレイション | 4−アミノ−3−キノリンカルボニトリルの調製方法 |
AU2005206541A1 (en) * | 2004-01-16 | 2005-08-04 | Wyeth | Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof |
-
2006
- 2006-04-26 WO PCT/US2006/015931 patent/WO2006127203A2/en active Application Filing
- 2006-04-26 CN CNA2006800177664A patent/CN101180273A/zh active Pending
- 2006-04-26 JP JP2008513496A patent/JP2008542266A/ja not_active Withdrawn
- 2006-04-26 MX MX2007014774A patent/MX2007014774A/es unknown
- 2006-04-26 EP EP06751575A patent/EP1883630A2/en not_active Withdrawn
- 2006-04-26 KR KR1020077028377A patent/KR20080016604A/ko not_active Application Discontinuation
- 2006-04-26 BR BRPI0610142-9A patent/BRPI0610142A2/pt not_active IP Right Cessation
- 2006-04-26 RU RU2007140957/04A patent/RU2007140957A/ru not_active Application Discontinuation
- 2006-04-26 CA CA002608589A patent/CA2608589A1/en not_active Abandoned
- 2006-04-26 AU AU2006249596A patent/AU2006249596A1/en not_active Abandoned
- 2006-05-04 TW TW095115892A patent/TW200716556A/zh unknown
- 2006-05-18 AR ARP060102011A patent/AR054192A1/es unknown
- 2006-05-22 PE PE2006000538A patent/PE20070007A1/es not_active Application Discontinuation
- 2006-05-24 GT GT200600215A patent/GT200600215A/es unknown
- 2006-05-25 PA PA20068676301A patent/PA8676301A1/es unknown
- 2006-05-25 US US11/442,562 patent/US20060270670A1/en not_active Abandoned
-
2007
- 2007-11-09 NO NO20075726A patent/NO20075726L/no not_active Application Discontinuation
- 2007-11-11 IL IL187301A patent/IL187301A0/en unknown
- 2007-11-23 CR CR9545A patent/CR9545A/es not_active Application Discontinuation
- 2007-11-26 ZA ZA200710143A patent/ZA200710143B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200710143B (en) | 2008-11-26 |
IL187301A0 (en) | 2008-04-13 |
TW200716556A (en) | 2007-05-01 |
PA8676301A1 (es) | 2009-03-31 |
NO20075726L (no) | 2008-02-04 |
AU2006249596A1 (en) | 2006-11-30 |
CN101180273A (zh) | 2008-05-14 |
CA2608589A1 (en) | 2006-11-30 |
AR054192A1 (es) | 2007-06-06 |
WO2006127203A3 (en) | 2007-05-03 |
KR20080016604A (ko) | 2008-02-21 |
US20060270670A1 (en) | 2006-11-30 |
RU2007140957A (ru) | 2009-06-27 |
JP2008542266A (ja) | 2008-11-27 |
PE20070007A1 (es) | 2007-02-12 |
BRPI0610142A2 (pt) | 2011-01-04 |
GT200600215A (es) | 2006-12-26 |
MX2007014774A (es) | 2008-02-19 |
WO2006127203A2 (en) | 2006-11-30 |
EP1883630A2 (en) | 2008-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |