PE20060951A1 - Proceso sintetico para la preparacion de compuestos aromaticos biciclicos - Google Patents
Proceso sintetico para la preparacion de compuestos aromaticos biciclicosInfo
- Publication number
- PE20060951A1 PE20060951A1 PE2006000001A PE2006000001A PE20060951A1 PE 20060951 A1 PE20060951 A1 PE 20060951A1 PE 2006000001 A PE2006000001 A PE 2006000001A PE 2006000001 A PE2006000001 A PE 2006000001A PE 20060951 A1 PE20060951 A1 PE 20060951A1
- Authority
- PE
- Peru
- Prior art keywords
- members
- compound
- preparation
- aromatic compounds
- heteroatomes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A PROCESOS PARA LA PREPARACION DE COMPUESTOS AROMATICOS BICICLICOS DE FORMULA (IV), EN DONDE A ES UN CABOCICLICO DE 5 A 6 MIEMBROS, OPCIONALMENTE CON UNO O MAS HETEROATOMOS DE N, O Y S, CON LA CONDICION DE QUE CUANDO X SEA N; A SERA UN HETEROCICLO DE 5 MIEMBROS; R1 ES ALQUILO, ARILO, HETEROARILO, HETEROCICLILO, OPCIONALMENTE SUSTITUIDOS; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; O JUNTOS AL N QUE ESTAN UNIDOS FORMAN UN HETEROCICLO DE 5 A 7 MIEMBROS CON UNO O MAS HETEROATOMOS DE N, O Y S; X ES C O N; QUE COMPRENDE LAS ETAPAS DE HACER REACCIONAR UN COMPUESTO DE FORMULA (I), CON N-BROMOSUCCINIMIDA EN LA PRESENCIA DE UN AGENTE DE ACTIVACION TAL COMO 2',2'-AZOBISISOBUTIRONITRILO O PEROXIDO DE BENZOILO SEGUIDO POR TRATAMIENTO CON UNA TRIALQUILAMINA: (R)3N, AL PRODUCTO OBTENIDO, SE HACE REACCIONAR CONSECUTIVAMENTE CON UNA AMINA PRIMARIA: -R1NH2, PARA DAR UN COMPUESTO (III), EL CUAL SE HACE REACCIONAR CON UN NUCEOFILO: (R2)(R3)NH, EN LA PRESENCIA DE UNA BASE TAL COMO TRIETILAMINA O DIISOPROPILETILAMINA PARA DAR EL COMPUESTO (IV). ESTOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LA TIROSINA CINASA DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO TALES COMO HER1, HER2 Y HER4, SIENDO UTILES COMO AGENTES ANTIPROLIFERATIVOS PARA EL TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63833504P | 2004-12-22 | 2004-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060951A1 true PE20060951A1 (es) | 2006-09-14 |
Family
ID=36177994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000001A PE20060951A1 (es) | 2004-12-22 | 2006-01-03 | Proceso sintetico para la preparacion de compuestos aromaticos biciclicos |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060155125A1 (es) |
EP (1) | EP1896475A2 (es) |
JP (1) | JP2008525503A (es) |
CN (1) | CN101087792A (es) |
AR (1) | AR052276A1 (es) |
NO (1) | NO20072667L (es) |
PE (1) | PE20060951A1 (es) |
TW (1) | TW200635927A (es) |
WO (1) | WO2006069395A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006104971A1 (en) * | 2005-03-28 | 2006-10-05 | Bristol-Myers Squibb Company | Atp competitive kinase inhibitors |
AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
UY34484A (es) * | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
US9724352B2 (en) | 2012-05-31 | 2017-08-08 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof |
CN103450204B (zh) | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
JP2005529890A (ja) * | 2002-04-23 | 2005-10-06 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なアリールケトンピロロトリアジン化合物 |
US7102001B2 (en) * | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7102003B2 (en) * | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
-
2005
- 2005-12-16 TW TW094144843A patent/TW200635927A/zh unknown
- 2005-12-21 WO PCT/US2005/047630 patent/WO2006069395A2/en active Application Filing
- 2005-12-21 JP JP2007548614A patent/JP2008525503A/ja not_active Withdrawn
- 2005-12-21 CN CNA2005800442330A patent/CN101087792A/zh active Pending
- 2005-12-21 US US11/314,794 patent/US20060155125A1/en not_active Abandoned
- 2005-12-21 EP EP05856095A patent/EP1896475A2/en not_active Withdrawn
- 2005-12-22 AR ARP050105516A patent/AR052276A1/es unknown
-
2006
- 2006-01-03 PE PE2006000001A patent/PE20060951A1/es not_active Application Discontinuation
-
2007
- 2007-05-25 NO NO20072667A patent/NO20072667L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20072667L (no) | 2007-09-06 |
TW200635927A (en) | 2006-10-16 |
CN101087792A (zh) | 2007-12-12 |
EP1896475A2 (en) | 2008-03-12 |
WO2006069395A2 (en) | 2006-06-29 |
AR052276A1 (es) | 2007-03-07 |
WO2006069395A3 (en) | 2006-10-19 |
JP2008525503A (ja) | 2008-07-17 |
US20060155125A1 (en) | 2006-07-13 |
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