PE20070805A1 - Imidazopirazinas como inhibidores de proteinquinasa - Google Patents
Imidazopirazinas como inhibidores de proteinquinasaInfo
- Publication number
- PE20070805A1 PE20070805A1 PE2006001398A PE2006001398A PE20070805A1 PE 20070805 A1 PE20070805 A1 PE 20070805A1 PE 2006001398 A PE2006001398 A PE 2006001398A PE 2006001398 A PE2006001398 A PE 2006001398A PE 20070805 A1 PE20070805 A1 PE 20070805A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- inhibitors
- heteroaryl
- alkyl
- proteinquinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRAZINA DE FORMULA (I) DONDE R ES H, CN, CICLOALQUILO(C3-C10), HETEROARILO DE 5 A 14 MIEMBROS, ENTRE OTROS; R1 ES H, HALO, ARILO(C6-C14) O HETEROARILO DE 5 A 14 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALO, ALQUILO(C1-C20), ALQUENILO(C2-C15), ALQUINILO(C2-C15), ENTRE OTROS SUSTITUYENTES; R2 ES H, HALO, ARILO(C6-C14), ARILALQUILO O HETEROARILO DE 5 A 14 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALO, AMIDA, ALQUILO(C1-C20), ENTRE OTROS SUSTITUYENTES; R3 ES H, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (a), (b), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINQUINASA SIENDO UTILES PARA EL TRATAMIENTO DE CANCER DE VEJIGA, LEUCEMIA, FIBROSARCOMA, GLIOMA, MELANOMA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73598205P | 2005-11-10 | 2005-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070805A1 true PE20070805A1 (es) | 2007-08-13 |
Family
ID=38008330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001398A PE20070805A1 (es) | 2005-11-10 | 2006-11-08 | Imidazopirazinas como inhibidores de proteinquinasa |
Country Status (17)
Country | Link |
---|---|
US (1) | US20070117804A1 (es) |
EP (1) | EP1945644A2 (es) |
JP (1) | JP5031760B2 (es) |
KR (1) | KR20080074963A (es) |
CN (1) | CN101370811A (es) |
AR (1) | AR056785A1 (es) |
AU (1) | AU2006315718B2 (es) |
BR (1) | BRPI0618520A2 (es) |
CA (1) | CA2628455A1 (es) |
EC (1) | ECSP088440A (es) |
IL (1) | IL191294A0 (es) |
NO (1) | NO20082530L (es) |
PE (1) | PE20070805A1 (es) |
RU (1) | RU2008122967A (es) |
TW (1) | TW200804386A (es) |
WO (1) | WO2007058942A2 (es) |
ZA (1) | ZA200803894B (es) |
Families Citing this family (80)
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US7576085B2 (en) * | 2002-09-23 | 2009-08-18 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
EP1945216A1 (en) * | 2005-11-10 | 2008-07-23 | Schering Corporation | Methods for inhibiting protein kinases |
PT2029602E (pt) * | 2006-05-31 | 2010-07-08 | Galapagos Nv | Compostos de triazolopirazina uteis para o tratamento de doenãas degenerativas e inflamatërias |
US20080125358A1 (en) * | 2006-10-26 | 2008-05-29 | University Of Massachusetts Medical School | Methods for Chk2 inhibitor patient selection |
PE20080931A1 (es) * | 2006-11-08 | 2008-07-19 | Schering Corp | Imidazopirazinas como inhibidores de proteina quinasa |
EP2086540B8 (en) * | 2006-12-01 | 2011-03-02 | Galapagos N.V. | Triazolopyridine compounds useful for the treatment of degenerative & inflammatory diseases |
WO2008138842A1 (en) | 2007-05-10 | 2008-11-20 | Galapagos N.V. | Imidazopyrazines and triazolopyrazine for the treatment of joint degenerative and inflammatory diseases |
MX2009013729A (es) * | 2007-06-14 | 2010-01-25 | Schering Corp | Imidazopirazinas como inhibidores de proteina quinasa. |
US20100249030A1 (en) * | 2007-07-31 | 2010-09-30 | Schering Corporation | Anti-mitotic agent and aurora kinase inhibitor combination as anti-cancer treatment |
GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
US20100216994A1 (en) * | 2007-10-30 | 2010-08-26 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
CA2705092A1 (en) * | 2007-11-07 | 2009-05-14 | Schering Corporation | Novel modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
WO2009081789A1 (ja) * | 2007-12-26 | 2009-07-02 | Banyu Pharmaceutical Co., Ltd. | スルホニル置換六員環誘導体 |
CA2710929A1 (en) * | 2008-01-28 | 2009-08-06 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
NZ587039A (en) | 2008-02-13 | 2013-01-25 | Gilead Connecticut Inc | 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof |
US20090207142A1 (en) * | 2008-02-20 | 2009-08-20 | Nokia Corporation | Apparatus, method, computer program and user interface for enabling user input |
AR070531A1 (es) * | 2008-03-03 | 2010-04-14 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso |
US8168794B2 (en) | 2008-03-03 | 2012-05-01 | Novartis Ag | Pim kinase inhibitors and methods of their use |
FR2933409B1 (fr) * | 2008-07-03 | 2010-08-27 | Centre Nat Rech Scient | NOUVEAUX PYRROLO °2,3-a! CARBAZOLES ET LEUR UTILISATION COMME INHIBITEURS DES KINASES PIM |
BRPI0922226A2 (pt) | 2008-12-08 | 2015-12-29 | Gilead Connecticut Inc | inibidores de syk imidazopirazina. |
TWI478922B (zh) | 2008-12-08 | 2015-04-01 | Gilead Connenticut Inc | 作為脾臟酪胺酸激酶(Syk)抑制劑之咪唑並吡化合物 |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
WO2011051342A1 (en) | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
MX2012008259A (es) | 2010-01-15 | 2012-08-17 | Janssen Pharmaceuticals Inc | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa. |
US8470820B2 (en) | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
US8658794B2 (en) * | 2010-02-08 | 2014-02-25 | Merck Sharp & Dohme B.V. | 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
EP2545052B1 (en) | 2010-03-11 | 2014-11-12 | Gilead Connecticut, Inc. | Imidazopyridines syk inhibitors |
ES2551407T3 (es) | 2010-03-18 | 2015-11-18 | Bayer Intellectual Property Gmbh | Imidazopirazinas |
ES2555261T3 (es) * | 2010-06-01 | 2015-12-30 | Bayer Intellectual Property Gmbh | Imidazopirazinas sustituidas |
TWI541243B (zh) * | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
CA2821827A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
US20140135319A1 (en) * | 2010-12-17 | 2014-05-15 | Bayer Intellectual Property Gmbh | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
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- 2006-11-08 JP JP2008540211A patent/JP5031760B2/ja not_active Expired - Fee Related
- 2006-11-08 TW TW095141238A patent/TW200804386A/zh unknown
- 2006-11-08 CN CNA2006800507096A patent/CN101370811A/zh active Pending
- 2006-11-08 WO PCT/US2006/043786 patent/WO2007058942A2/en active Application Filing
- 2006-11-08 KR KR1020087013635A patent/KR20080074963A/ko not_active Application Discontinuation
- 2006-11-08 BR BRPI0618520-7A patent/BRPI0618520A2/pt not_active IP Right Cessation
- 2006-11-08 CA CA002628455A patent/CA2628455A1/en not_active Abandoned
- 2006-11-08 AR ARP060104896A patent/AR056785A1/es unknown
- 2006-11-08 PE PE2006001398A patent/PE20070805A1/es not_active Application Discontinuation
- 2006-11-08 EP EP06837322A patent/EP1945644A2/en not_active Withdrawn
- 2006-11-08 RU RU2008122967/04A patent/RU2008122967A/ru not_active Application Discontinuation
- 2006-11-08 US US11/598,186 patent/US20070117804A1/en not_active Abandoned
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AU2006315718A1 (en) | 2007-05-24 |
RU2008122967A (ru) | 2009-12-20 |
TW200804386A (en) | 2008-01-16 |
JP5031760B2 (ja) | 2012-09-26 |
ZA200803894B (en) | 2009-03-25 |
NO20082530L (no) | 2008-08-07 |
EP1945644A2 (en) | 2008-07-23 |
US20070117804A1 (en) | 2007-05-24 |
IL191294A0 (en) | 2009-02-11 |
BRPI0618520A2 (pt) | 2011-09-06 |
JP2009515888A (ja) | 2009-04-16 |
AU2006315718B2 (en) | 2012-10-04 |
ECSP088440A (es) | 2008-06-30 |
AR056785A1 (es) | 2007-10-24 |
CN101370811A (zh) | 2009-02-18 |
WO2007058942A2 (en) | 2007-05-24 |
CA2628455A1 (en) | 2007-05-24 |
WO2007058942A3 (en) | 2007-11-15 |
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