PA8676301A1 - Metodos para sintetizar derivados de 6-alquilaminoquinolina - Google Patents

Metodos para sintetizar derivados de 6-alquilaminoquinolina

Info

Publication number
PA8676301A1
PA8676301A1 PA20068676301A PA8676301A PA8676301A1 PA 8676301 A1 PA8676301 A1 PA 8676301A1 PA 20068676301 A PA20068676301 A PA 20068676301A PA 8676301 A PA8676301 A PA 8676301A PA 8676301 A1 PA8676301 A1 PA 8676301A1
Authority
PA
Panama
Prior art keywords
methods
alquilaminoquinolina
synthesizing
synthesizing derivatives
compounds
Prior art date
Application number
PA20068676301A
Other languages
English (en)
Inventor
Warren Chew
Wang Youchu
Sridhar Rabindran
Discafani-Marro
John Patrick Mcginnis Iii
Allan Wissner
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8676301A1 publication Critical patent/PA8676301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN MÉTODO PARA SINTETIZAR COMPUESTOS DE FÒRMULA (1): DONDE X,Z,V,R1,R3,R4,G2,N,X,Y, Y Z SE DEFINEN EN LA PRESENTE. ESTA INVENCIÓN ADEMÁS INCLUYE UN MÉTODO PARA PREPARAR COMPUESTOS ÁCIDOS DE FÓRMULA (VII): DONDE R ES H, Y R4,V,X,Y, Y Z SON SEGÚN SE DEFINIERON ANTERIORMENTE Y PG ES UN GRUPO PROTECTOR. ESTA INVENCIÓN ADEMÁS SE REFIERE A (E) N-{4-[3-CLORO-4-(2-PIRIDINILMETOXI)ANILINO]-3-CIANO-7-ETOXI-6-QUINOLINIL}-4-(METILAMINO)-2- BUTENAMIDA, A COMPOSICIONES QUE LA CONTIENEN Y A MÉTODOS PARA UTILIZARLAS PARA TRATAR EL CÁNCER.
PA20068676301A 2005-05-25 2006-05-25 Metodos para sintetizar derivados de 6-alquilaminoquinolina PA8676301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68504005P 2005-05-25 2005-05-25

Publications (1)

Publication Number Publication Date
PA8676301A1 true PA8676301A1 (es) 2009-03-31

Family

ID=36794434

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20068676301A PA8676301A1 (es) 2005-05-25 2006-05-25 Metodos para sintetizar derivados de 6-alquilaminoquinolina

Country Status (20)

Country Link
US (1) US20060270670A1 (es)
EP (1) EP1883630A2 (es)
JP (1) JP2008542266A (es)
KR (1) KR20080016604A (es)
CN (1) CN101180273A (es)
AR (1) AR054192A1 (es)
AU (1) AU2006249596A1 (es)
BR (1) BRPI0610142A2 (es)
CA (1) CA2608589A1 (es)
CR (1) CR9545A (es)
GT (1) GT200600215A (es)
IL (1) IL187301A0 (es)
MX (1) MX2007014774A (es)
NO (1) NO20075726L (es)
PA (1) PA8676301A1 (es)
PE (1) PE20070007A1 (es)
RU (1) RU2007140957A (es)
TW (1) TW200716556A (es)
WO (1) WO2006127203A2 (es)
ZA (1) ZA200710143B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1910297B1 (en) * 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
US20070135499A1 (en) * 2005-07-11 2007-06-14 Aerie Pharmaceuticals, Inc. Hydrazide compounds
WO2008036540A2 (en) 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8394826B2 (en) 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US8779192B2 (en) 2009-05-14 2014-07-15 Kolon Life Science, Inc. Process of preparing an alkylamine derivative
EP2621923B1 (en) 2010-09-29 2017-03-29 Intervet International B.V. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
PL2621903T3 (pl) 2010-09-29 2017-08-31 Intervet International B.V. Związki n-heteroarylu
CN102649778A (zh) * 2011-02-23 2012-08-29 苏州波锐生物医药科技有限公司 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途
CN104203242B (zh) * 2012-04-04 2017-03-15 杭州德润玉成生物科技有限公司 取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂
EP3811943B1 (en) 2013-03-15 2023-02-22 Aerie Pharmaceuticals, Inc. Compound for use in the treatment of ocular disorders
US9556191B2 (en) 2013-04-28 2017-01-31 Sunshine Lake Pharma Co., Ltd. Aminoquinazoline derivatives and their salts and methods of use thereof
CA3005707C (en) 2015-11-17 2023-11-21 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CA3021471A1 (en) * 2016-04-28 2017-11-02 Guaili Wu Method for preparing tyrosine kinase inhibitor and derivative thereof
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
CN110506037A (zh) 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
AU4545201A (en) * 2000-03-13 2001-09-24 American Cyanamid Co Method of treating or inhibiting colonic polyps
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
MXPA04007495A (es) * 2002-02-05 2004-11-10 Wyeth Corp Proceso para sintesis de acidos n-acil2-amino-4-alcoxi-5-nitrobenzoicos.
CL2004000016A1 (es) * 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
MXPA06001590A (es) * 2003-08-19 2006-05-19 Wyeth Corp Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos.
UA85698C2 (ru) * 2004-01-16 2009-02-25 Уайет Хинолиновые промежуточные соединения для синтеза ингибиторов рецепторной тирозинкиназы и способ их получения

Also Published As

Publication number Publication date
AR054192A1 (es) 2007-06-06
CA2608589A1 (en) 2006-11-30
WO2006127203A2 (en) 2006-11-30
CR9545A (es) 2008-01-10
BRPI0610142A2 (pt) 2011-01-04
WO2006127203A3 (en) 2007-05-03
MX2007014774A (es) 2008-02-19
RU2007140957A (ru) 2009-06-27
US20060270670A1 (en) 2006-11-30
ZA200710143B (en) 2008-11-26
IL187301A0 (en) 2008-04-13
NO20075726L (no) 2008-02-04
JP2008542266A (ja) 2008-11-27
KR20080016604A (ko) 2008-02-21
AU2006249596A1 (en) 2006-11-30
GT200600215A (es) 2006-12-26
EP1883630A2 (en) 2008-02-06
PE20070007A1 (es) 2007-02-12
CN101180273A (zh) 2008-05-14
TW200716556A (en) 2007-05-01

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