BR0307721A - Processo para preparação de derivados de indolinona - Google Patents
Processo para preparação de derivados de indolinonaInfo
- Publication number
- BR0307721A BR0307721A BR0307721-7A BR0307721A BR0307721A BR 0307721 A BR0307721 A BR 0307721A BR 0307721 A BR0307721 A BR 0307721A BR 0307721 A BR0307721 A BR 0307721A
- Authority
- BR
- Brazil
- Prior art keywords
- indolinone derivatives
- preparing
- preparing indolinone
- derivatives
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
"PROCESSO PARA PREPARAçãO DE DERIVADOS DE INDOLINONA". A presente invenção refere-se a um processo para preparação de derivados de indolinona da fórmula geral (VI) como definida no relatório descritivo e intermediários daquele processo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2002/004407 WO2002066463A1 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
US41173202P | 2002-09-18 | 2002-09-18 | |
PCT/US2003/004520 WO2003070725A2 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0307721A true BR0307721A (pt) | 2005-01-25 |
Family
ID=33029733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0307721-7A BR0307721A (pt) | 2002-02-15 | 2003-02-14 | Processo para preparação de derivados de indolinona |
Country Status (16)
Country | Link |
---|---|
US (2) | US7119209B2 (pt) |
EP (1) | EP1476443A2 (pt) |
JP (1) | JP2005528344A (pt) |
KR (1) | KR100657110B1 (pt) |
CN (1) | CN1308326C (pt) |
AR (1) | AR041247A1 (pt) |
AU (1) | AU2003216282A1 (pt) |
BR (1) | BR0307721A (pt) |
CA (1) | CA2475455A1 (pt) |
HK (1) | HK1078075A1 (pt) |
MX (1) | MXPA04006992A (pt) |
PL (1) | PL372302A1 (pt) |
RS (1) | RS70904A (pt) |
RU (1) | RU2299209C2 (pt) |
TW (1) | TWI289560B (pt) |
WO (1) | WO2003070725A2 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
EP1476443A2 (en) * | 2002-02-15 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Process for preparing indolinone derivatives |
US7452913B2 (en) * | 2003-02-24 | 2008-11-18 | Pharmacia & Upjohn Company | Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors |
WO2005023765A1 (en) * | 2003-09-11 | 2005-03-17 | Pharmacia & Upjohn Company Llc | Method for catalyzing amidation reactions by the presence of co2 |
BRPI0415022A (pt) * | 2003-10-02 | 2006-11-28 | Pharmacia & Upjohn Co Llc | sais e polimorfos de um composto de indolinona substituìda com pirrol |
US20060009510A1 (en) * | 2004-07-09 | 2006-01-12 | Pharmacia & Upjohn Company Llc | Method of synthesizing indolinone compounds |
US20100267719A1 (en) * | 2005-05-26 | 2010-10-21 | The Scripps Research Institute | Enhanced Indolinone Based Protein Kinase Inhibitors |
ES2328407T3 (es) | 2005-09-19 | 2009-11-12 | Pfizer Products Incorporated | Formas salinas solidas de una 2-indolinona sustituida con pirrol. |
US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
US20100256392A1 (en) * | 2007-11-21 | 2010-10-07 | Teva Pharmaceutical Industries Ltd. | Polymorphs of sunitinib base and processes for preparation thereof |
WO2009067686A2 (en) * | 2007-11-21 | 2009-05-28 | Teva Pharmaceutical Industries Ltd. | Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof |
EP2098521A1 (en) * | 2008-03-06 | 2009-09-09 | Ratiopharm GmbH | Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation |
WO2009124037A1 (en) * | 2008-03-31 | 2009-10-08 | Teva Pharmaceutical Industries Ltd. | Processes for preparing sunitinib and salts thereof |
US8466190B2 (en) | 2008-04-16 | 2013-06-18 | Natco Pharma Limited | Polymorphic forms of Sunitinib base |
WO2009157011A1 (en) | 2008-06-23 | 2009-12-30 | Natco Pharma Limited | Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt |
WO2009156837A2 (en) * | 2008-06-26 | 2009-12-30 | Medichem, S.A. | Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt |
WO2010011834A2 (en) | 2008-07-24 | 2010-01-28 | Teva Pharmaceutical Industries Ltd. | Sunitinib and salts thereof and their polymorphs |
EP2318393A1 (en) * | 2008-08-25 | 2011-05-11 | Generics [UK] Limited | Novel polymorphs of sunitinib and processes for their preparation |
JP2012500837A (ja) * | 2008-08-25 | 2012-01-12 | ジェネリクス・(ユーケー)・リミテッド | 新規な結晶型およびその調製方法 |
WO2011004200A1 (en) | 2009-07-10 | 2011-01-13 | Generics [Uk] Limited | Novel pyrrole derivatives |
WO2011104555A2 (en) | 2010-02-25 | 2011-09-01 | Generics [Uk] Limited | Novel process |
EP2545034A1 (en) | 2010-03-10 | 2013-01-16 | Synthon B.V. | A process for amidation of pyrrole carboxylate compounds |
WO2011128699A2 (en) | 2010-04-16 | 2011-10-20 | Generics [Uk] Limited | Novel process |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
EP2635568B1 (en) | 2010-11-01 | 2017-08-16 | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles |
WO2012139019A2 (en) * | 2011-04-08 | 2012-10-11 | Beta Pharma, Inc. | New indolinone protein kinase inhibitors |
SG10201603896RA (en) | 2012-05-04 | 2016-07-28 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
HUE043042T2 (hu) | 2013-11-01 | 2019-07-29 | Pfizer | Vektorok prosztatához kapcsolódó antigének expressziójára |
CN104744442B (zh) * | 2013-12-25 | 2019-05-28 | 江苏豪森药业集团有限公司 | 苹果酸舒尼替尼的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
WO1998038984A2 (en) | 1997-03-05 | 1998-09-11 | Sugen, Inc. | Formulations for hydrophobic pharmaceutical agents |
US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
US6133305A (en) | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
JP2002507598A (ja) | 1998-03-26 | 2002-03-12 | スージェン・インコーポレーテッド | チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー |
PT1255536E (pt) | 1999-12-22 | 2006-09-29 | Sugen Inc | Derivados de indolinona para a modulacao da tirosina proteina cinase de tipo c-kit |
ATE369359T1 (de) * | 2000-02-15 | 2007-08-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
EP1476443A2 (en) * | 2002-02-15 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Process for preparing indolinone derivatives |
-
2003
- 2003-02-14 EP EP03742760A patent/EP1476443A2/en not_active Withdrawn
- 2003-02-14 US US10/367,008 patent/US7119209B2/en not_active Expired - Fee Related
- 2003-02-14 RU RU2004124711/04A patent/RU2299209C2/ru not_active IP Right Cessation
- 2003-02-14 WO PCT/US2003/004520 patent/WO2003070725A2/en active Application Filing
- 2003-02-14 BR BR0307721-7A patent/BR0307721A/pt not_active IP Right Cessation
- 2003-02-14 PL PL03372302A patent/PL372302A1/xx not_active Application Discontinuation
- 2003-02-14 RS YU70904A patent/RS70904A/sr unknown
- 2003-02-14 JP JP2003569632A patent/JP2005528344A/ja active Pending
- 2003-02-14 CA CA002475455A patent/CA2475455A1/en not_active Abandoned
- 2003-02-14 KR KR1020047012598A patent/KR100657110B1/ko not_active IP Right Cessation
- 2003-02-14 AU AU2003216282A patent/AU2003216282A1/en not_active Abandoned
- 2003-02-14 CN CNB038039885A patent/CN1308326C/zh not_active Expired - Fee Related
- 2003-02-14 MX MXPA04006992A patent/MXPA04006992A/es active IP Right Grant
- 2003-09-12 AR ARP030103313A patent/AR041247A1/es unknown
- 2003-09-17 TW TW092125614A patent/TWI289560B/zh not_active IP Right Cessation
-
2005
- 2005-03-30 US US11/095,433 patent/US20050171357A1/en not_active Abandoned
- 2005-11-09 HK HK05109991A patent/HK1078075A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20030229229A1 (en) | 2003-12-11 |
MXPA04006992A (es) | 2004-11-10 |
KR20040081203A (ko) | 2004-09-20 |
TWI289560B (en) | 2007-11-11 |
KR100657110B1 (ko) | 2006-12-12 |
RS70904A (en) | 2006-10-27 |
JP2005528344A (ja) | 2005-09-22 |
RU2004124711A (ru) | 2006-01-20 |
CN1671693A (zh) | 2005-09-21 |
HK1078075A1 (en) | 2006-03-03 |
AU2003216282A1 (en) | 2003-09-09 |
CA2475455A1 (en) | 2003-08-28 |
WO2003070725A2 (en) | 2003-08-28 |
US7119209B2 (en) | 2006-10-10 |
TW200410958A (en) | 2004-07-01 |
PL372302A1 (en) | 2005-07-11 |
US20050171357A1 (en) | 2005-08-04 |
EP1476443A2 (en) | 2004-11-17 |
CN1308326C (zh) | 2007-04-04 |
RU2299209C2 (ru) | 2007-05-20 |
AR041247A1 (es) | 2005-05-11 |
WO2003070725A3 (en) | 2004-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0307721A (pt) | Processo para preparação de derivados de indolinona | |
BR0307529A (pt) | Derivados de n-fenil-2-pirimidina-amina | |
BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
BRPI0408369A (pt) | derivados de indol úteis para o tratamento de doenças | |
BR0308967A (pt) | Derivados de quinolina e isoquinolina, um processo para a sua preparação e sua aplicação como inibidores de inflamação | |
BRPI0518601A2 (pt) | processo para preparaÇço de derivados de piperazin-2-ona anelados bem como produtos intermediÁrios do processo | |
BR0311494A (pt) | Novos indóis substituìdos | |
BRPI0407967A (pt) | processo de uma etapa para a preparação de derivados anticonvulsivantes | |
BR0316350A (pt) | Diaminotriazóis úteis como inibidores de proteìna cinases | |
EA200600621A1 (ru) | Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
AR022469A1 (es) | Uso de acidos isoxazolcarboxilicos sustituidos y derivados y nuevas sustancias | |
BRPI0511956A (pt) | processo para a preparação dos compostos, e, intermediários de sìntese | |
TW200716152A (en) | Substituted 1,2-ethylendiamines, medicaments comprising said compound, their use and their method of manufacture | |
CR9182A (es) | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene | |
TW200716564A (en) | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | |
BRPI0414436A (pt) | processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais | |
BRPI0517390A (pt) | processo para a preparação de derivados de [1,4,5]-oxadiazepina | |
BRPI0407282A (pt) | Processo para preparação de inibidores de pirrolotriazina cinase | |
BR0208534A (pt) | Processo para preparação de 4,6-diaminopirimido[5,4-d]pirimidinas | |
CY1109569T1 (el) | Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης | |
BR0314195A (pt) | Derivados de piridina substituìda como agentes antitumorais | |
TW200621703A (en) | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | |
BRPI0411209A (pt) | uso de derivados isoindolinona como inseticidas | |
BR0301667A (pt) | Processo para a preparação de polìmeros em emulsão com pureza elevada | |
EA200701852A1 (ru) | Производные аминокислот |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011. |