BRPI0518601A2 - processo para preparaÇço de derivados de piperazin-2-ona anelados bem como produtos intermediÁrios do processo - Google Patents

processo para preparaÇço de derivados de piperazin-2-ona anelados bem como produtos intermediÁrios do processo

Info

Publication number
BRPI0518601A2
BRPI0518601A2 BRPI0518601-3A BRPI0518601A BRPI0518601A2 BR PI0518601 A2 BRPI0518601 A2 BR PI0518601A2 BR PI0518601 A BRPI0518601 A BR PI0518601A BR PI0518601 A2 BRPI0518601 A2 BR PI0518601A2
Authority
BR
Brazil
Prior art keywords
derivatives
piperazin
preparation
well
ring
Prior art date
Application number
BRPI0518601-3A
Other languages
English (en)
Inventor
Guenter Linz
Adil Duran
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35923724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0518601(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0518601A2 publication Critical patent/BRPI0518601A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCESSO PARA PREPARAÇçO DE DERIVADOS DE PIPERAZIN-2-ONA ANELADOS BEM COMO PRODUTOS INTERME DIÁRIOS DO PROCESSO. A presente invenção refere-se a um processo para preparação de derivados de piperazin-2-ona anelados da fórmula geral em que os radicais R¹ até R^ 5^, A~ 1~ e A~ 2~ possuem os significados mencionados nas reivindicações e na descrição, particularmente para preparação de derivados de 7,8-dihidro-5H-pteridin-6-ona.
BRPI0518601-3A 2004-12-02 2005-11-29 processo para preparaÇço de derivados de piperazin-2-ona anelados bem como produtos intermediÁrios do processo BRPI0518601A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Publications (1)

Publication Number Publication Date
BRPI0518601A2 true BRPI0518601A2 (pt) 2008-11-25

Family

ID=35923724

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518601-3A BRPI0518601A2 (pt) 2004-12-02 2005-11-29 processo para preparaÇço de derivados de piperazin-2-ona anelados bem como produtos intermediÁrios do processo

Country Status (35)

Country Link
US (9) US7238807B2 (pt)
EP (2) EP2436685B1 (pt)
JP (1) JP5164574B2 (pt)
KR (2) KR101362131B1 (pt)
CN (3) CN102093361B (pt)
AR (1) AR053100A1 (pt)
AU (1) AU2005311308B2 (pt)
BR (1) BRPI0518601A2 (pt)
CA (1) CA2588857C (pt)
CL (1) CL2013002895A1 (pt)
CY (1) CY1113625T1 (pt)
DE (1) DE102004058337A1 (pt)
DK (2) DK2436685T3 (pt)
EA (1) EA012624B1 (pt)
ES (2) ES2548680T3 (pt)
HK (3) HK1113489A1 (pt)
HR (1) HRP20120980T1 (pt)
HU (1) HUE027689T2 (pt)
IL (1) IL183568A (pt)
ME (1) ME01470B (pt)
MX (1) MX2007006549A (pt)
MY (1) MY147459A (pt)
NO (1) NO20072283L (pt)
NZ (1) NZ556182A (pt)
PE (2) PE20090488A1 (pt)
PL (2) PL1819706T3 (pt)
PT (1) PT1819706E (pt)
RS (1) RS52533B (pt)
SG (2) SG158848A1 (pt)
SI (1) SI1819706T1 (pt)
TW (1) TWI362391B (pt)
UA (1) UA89390C2 (pt)
UY (1) UY29233A1 (pt)
WO (1) WO2006058876A1 (pt)
ZA (1) ZA200703368B (pt)

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US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
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EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
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WO2011038185A2 (en) 2009-09-25 2011-03-31 Vertex Pharmaceuticals Incorporated Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US8791107B2 (en) 2011-02-25 2014-07-29 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UY34893A (es) 2012-07-10 2014-02-28 Takeda Pharmaceutical Derivados de azaindol
WO2015011236A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
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Also Published As

Publication number Publication date
SG141461A1 (en) 2008-04-28
US20070213528A1 (en) 2007-09-13
KR20120136414A (ko) 2012-12-18
US20070219369A1 (en) 2007-09-20
MY147459A (en) 2012-12-14
CA2588857C (en) 2013-10-08
JP2008521861A (ja) 2008-06-26
US20070213534A1 (en) 2007-09-13
IL183568A (en) 2015-02-26
AR053100A1 (es) 2007-04-25
CN101065381A (zh) 2007-10-31
EP2436685B1 (de) 2015-07-01
CN102093361A (zh) 2011-06-15
EP2436685A1 (de) 2012-04-04
HK1158199A1 (en) 2012-07-13
NZ556182A (en) 2009-08-28
DK1819706T3 (da) 2013-01-02
DK2436685T3 (en) 2015-09-14
SI1819706T1 (sl) 2013-01-31
CA2588857A1 (en) 2006-06-08
EP1819706B1 (de) 2012-09-19
US20070213530A1 (en) 2007-09-13
CN102093361B (zh) 2014-05-07
KR20070092252A (ko) 2007-09-12
HK1158200A1 (en) 2012-07-13
NO20072283L (no) 2007-06-28
PE20090488A1 (es) 2009-05-27
US20070213529A1 (en) 2007-09-13
HK1113489A1 (en) 2008-10-03
TWI362391B (en) 2012-04-21
CY1113625T1 (el) 2016-06-22
UY29233A1 (es) 2006-07-31
ES2548680T3 (es) 2015-10-20
PL1819706T3 (pl) 2013-03-29
PL2436685T3 (pl) 2015-11-30
AU2005311308A1 (en) 2006-06-08
HRP20120980T1 (hr) 2012-12-31
TW200628471A (en) 2006-08-16
PE20061061A1 (es) 2006-11-10
CL2013002895A1 (es) 2014-03-14
US20070208027A1 (en) 2007-09-06
AU2005311308B2 (en) 2012-04-12
US7238807B2 (en) 2007-07-03
HUE027689T2 (hu) 2021-12-28
IL183568A0 (en) 2007-09-20
UA89390C2 (ru) 2010-01-25
US7626019B2 (en) 2009-12-01
MX2007006549A (es) 2007-06-18
EA012624B1 (ru) 2009-10-30
USRE43115E1 (en) 2012-01-17
PT1819706E (pt) 2012-12-06
WO2006058876A1 (de) 2006-06-08
EP1819706A1 (de) 2007-08-22
US20060122393A1 (en) 2006-06-08
CN102070637B (zh) 2012-09-26
US20070213531A1 (en) 2007-09-13
SG158848A1 (en) 2010-02-26
ME01470B (me) 2014-04-20
JP5164574B2 (ja) 2013-03-21
DE102004058337A1 (de) 2006-06-14
RS52533B (en) 2013-04-30
KR101362131B1 (ko) 2014-02-19
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
KR101395591B1 (ko) 2014-05-16
ZA200703368B (en) 2008-09-25
ES2395829T3 (es) 2013-02-15
EA200701164A1 (ru) 2007-12-28

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