PL2436685T3 - Produkty pośrednie do wytwarzania skondensowanych pochodnych piperazyn-2-onu - Google Patents

Produkty pośrednie do wytwarzania skondensowanych pochodnych piperazyn-2-onu

Info

Publication number
PL2436685T3
PL2436685T3 PL11189691T PL11189691T PL2436685T3 PL 2436685 T3 PL2436685 T3 PL 2436685T3 PL 11189691 T PL11189691 T PL 11189691T PL 11189691 T PL11189691 T PL 11189691T PL 2436685 T3 PL2436685 T3 PL 2436685T3
Authority
PL
Poland
Prior art keywords
annulated
piperazine
derivatives
producing
intermediate products
Prior art date
Application number
PL11189691T
Other languages
English (en)
Inventor
Adil Duran
Guenter Linz
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35923724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2436685(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL2436685T3 publication Critical patent/PL2436685T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL11189691T 2004-12-02 2005-11-29 Produkty pośrednie do wytwarzania skondensowanych pochodnych piperazyn-2-onu PL2436685T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
EP05823799A EP1819706B1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens
EP11189691.6A EP2436685B1 (de) 2004-12-02 2005-11-29 Zwischenprodukte zur Herststellung von annelierten Piperazin-2-on Derivaten

Publications (1)

Publication Number Publication Date
PL2436685T3 true PL2436685T3 (pl) 2015-11-30

Family

ID=35923724

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11189691T PL2436685T3 (pl) 2004-12-02 2005-11-29 Produkty pośrednie do wytwarzania skondensowanych pochodnych piperazyn-2-onu
PL05823799T PL1819706T3 (pl) 2004-12-02 2005-11-29 Sposób wytwarzania skondensowanych pochodnych piperazyn-2-onu oraz produkty pośrednie tego sposobu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL05823799T PL1819706T3 (pl) 2004-12-02 2005-11-29 Sposób wytwarzania skondensowanych pochodnych piperazyn-2-onu oraz produkty pośrednie tego sposobu

Country Status (34)

Country Link
US (9) US7238807B2 (pl)
EP (2) EP1819706B1 (pl)
JP (1) JP5164574B2 (pl)
KR (2) KR101395591B1 (pl)
CN (3) CN101065381B (pl)
AR (1) AR053100A1 (pl)
AU (1) AU2005311308B2 (pl)
BR (1) BRPI0518601A2 (pl)
CA (1) CA2588857C (pl)
CL (1) CL2013002895A1 (pl)
CY (1) CY1113625T1 (pl)
DE (1) DE102004058337A1 (pl)
DK (2) DK2436685T3 (pl)
EA (1) EA012624B1 (pl)
ES (2) ES2548680T3 (pl)
HR (1) HRP20120980T1 (pl)
HU (1) HUE027689T2 (pl)
IL (1) IL183568A (pl)
ME (1) ME01470B (pl)
MX (1) MX2007006549A (pl)
MY (1) MY147459A (pl)
NO (1) NO20072283L (pl)
NZ (1) NZ556182A (pl)
PE (2) PE20090488A1 (pl)
PL (2) PL2436685T3 (pl)
PT (1) PT1819706E (pl)
RS (1) RS52533B (pl)
SG (2) SG141461A1 (pl)
SI (1) SI1819706T1 (pl)
TW (1) TWI362391B (pl)
UA (1) UA89390C2 (pl)
UY (1) UY29233A1 (pl)
WO (1) WO2006058876A1 (pl)
ZA (1) ZA200703368B (pl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de) * 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) * 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
AU2007215221C1 (en) 2006-02-14 2013-05-30 Vertex Pharmaceuticals Incorporated Dihydrodiazepines useful as inhibitors of protein kinases
JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
KR20090104920A (ko) 2007-02-01 2009-10-06 아스트라제네카 아베 Ｈｓｐ90 억제제로서 5,6,7,8-테트라히드로프테리딘 유도체
EP3098223A1 (en) * 2007-08-03 2016-11-30 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
SG179206A1 (en) 2009-09-25 2012-04-27 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
NZ599342A (en) 2009-09-25 2014-04-30 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
EP2678342B1 (en) 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UY34893A (es) 2012-07-10 2014-02-28 Takeda Pharmaceutical Derivados de azaindol
WO2015011236A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
AR099052A1 (es) 2014-01-09 2016-06-29 Takeda Pharmaceuticals Co Derivados de azaindol
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032639A (en) * 1976-03-22 1977-06-28 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension
US4182872A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates
NL8303657A (nl) 1983-10-24 1985-05-17 Pharmachemie Bv Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan.
DE3537761A1 (de) * 1985-10-24 1987-04-30 Bayer Ag Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE68908786T2 (de) 1988-06-16 1994-03-17 Smith Kline French Lab Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
FR2645152B1 (fr) 1989-03-30 1991-05-31 Lipha 3h-pteridinones-4, procedes de preparation et medicaments les contenant
US5043270A (en) 1989-03-31 1991-08-27 The Board Of Trustees Of The Leland Stanford Junior University Intronic overexpression vectors
CA2029651C (en) 1989-11-17 2000-06-06 David D. Davey Tricyclic pteridinones and a process for their preparation
US5198547A (en) 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
TW274550B (pl) * 1992-09-26 1996-04-21 Hoechst Ag
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
CO4410190A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
JP4454044B2 (ja) * 1995-05-19 2010-04-21 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 芳香族ニトロ化合物の接触水素化法
US5698556A (en) * 1995-06-07 1997-12-16 Chan; Carcy L. Methotrexate analogs and methods of using same
TR199900639T2 (xx) 1996-09-23 1999-06-21 Eli Lilly And Company Olanzapin dihidrat D.
SK1822001A3 (en) * 1998-08-11 2002-08-06 Pfizer Prod Inc Substituted 1,8-naphthyridin-4(1h)-ones as phosphodiesterase 4 inhibitors
KR20020027649A (ko) 1999-09-15 2002-04-13 로즈 암스트롱, 크리스틴 에이. 트러트웨인 카이나제 억제제로서의 프테리딘온
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
EE200200506A (et) 2000-03-06 2004-02-16 Warner-Lambert Company 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid
DE10018783A1 (de) 2000-04-15 2001-10-25 Fresenius Kabi De Gmbh Lagerstabile Infusionslösung des Ciprofloxacins mit verringertem Säuregehalt
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
DE10058119A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Pepinotan-Kit
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
WO2002076954A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
WO2002076985A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US6806272B2 (en) * 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
EA007062B1 (ru) 2001-09-04 2006-06-30 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
DK1463493T3 (da) * 2001-12-14 2008-02-04 Serono Lab Fremgangsmåder til at inducere æglösning ved anvendelse af en ikke polypeptid-cAMP-niveaumodulator
WO2003093249A1 (de) * 2002-05-03 2003-11-13 Schering Aktiengesellschaft Thiazolidinone und ihre verwendung als polo like kinase inhibitoren
PL375532A1 (pl) 2002-08-08 2005-11-28 Smithkline Beecham Corporation Związki benzimidazol-1-ilotiofenowe do leczenia nowotworów
US6862422B2 (en) * 2003-02-12 2005-03-01 Kabushiki Kaisha Toshiba Image forming apparatus and image forming method having pressing members for pressing a belt-like member
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
CA2517020C (en) 2003-02-26 2012-06-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, method for the production and use thereof in the form of drugs
US20040180898A1 (en) * 2003-03-03 2004-09-16 Bang-Chi Chen Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines
NZ542652A (en) 2003-03-26 2008-04-30 Wyeth Corp Immunogenic composition and methods
AU2004231342A1 (en) 2003-04-14 2004-11-04 Vectura Ltd Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
JP2007517828A (ja) * 2004-01-17 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 気道の疾患を治療するための置換プテリジンの使用
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
DE102004029784A1 (de) * 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) * 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
DE102004034623A1 (de) * 2004-07-16 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7759485B2 (en) 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
JP2008510770A (ja) * 2004-08-26 2008-04-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｌｋ阻害剤としての新規プテリジノン
JP2008510771A (ja) * 2004-08-27 2008-04-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
JP2009503014A (ja) 2005-08-03 2009-01-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器系疾患の治療におけるジヒドロプテリジノン
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
CN101437795A (zh) 2006-03-07 2009-05-20 阿斯利康(瑞典)有限公司 哌啶衍生物，制备它们的方法，它们作为治疗剂的用途和含有它们的药物组合物
EP3098223A1 (en) 2007-08-03 2016-11-30 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative

Also Published As

Publication number Publication date
AR053100A1 (es) 2007-04-25
USRE43115E1 (en) 2012-01-17
NZ556182A (en) 2009-08-28
HK1158200A1 (en) 2012-07-13
KR20120136414A (ko) 2012-12-18
CA2588857A1 (en) 2006-06-08
WO2006058876A1 (de) 2006-06-08
AU2005311308B2 (en) 2012-04-12
HK1158199A1 (en) 2012-07-13
RS52533B (sr) 2013-04-30
MX2007006549A (es) 2007-06-18
ME01470B (me) 2014-04-20
CL2013002895A1 (es) 2014-03-14
MY147459A (en) 2012-12-14
TW200628471A (en) 2006-08-16
AU2005311308A1 (en) 2006-06-08
HK1113489A1 (en) 2008-10-03
US20070208027A1 (en) 2007-09-06
PL1819706T3 (pl) 2013-03-29
CN102093361B (zh) 2014-05-07
CY1113625T1 (el) 2016-06-22
DK1819706T3 (da) 2013-01-02
EP1819706B1 (de) 2012-09-19
US20060122393A1 (en) 2006-06-08
US7626019B2 (en) 2009-12-01
KR101362131B1 (ko) 2014-02-19
CN102093361A (zh) 2011-06-15
US20070213531A1 (en) 2007-09-13
EA200701164A1 (ru) 2007-12-28
HUE027689T2 (hu) 2021-12-28
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
ZA200703368B (en) 2008-09-25
CN102070637B (zh) 2012-09-26
PE20061061A1 (es) 2006-11-10
CA2588857C (en) 2013-10-08
TWI362391B (en) 2012-04-21
CN101065381A (zh) 2007-10-31
EP2436685A1 (de) 2012-04-04
US20070213528A1 (en) 2007-09-13
DE102004058337A1 (de) 2006-06-14
SG158848A1 (en) 2010-02-26
US20070213530A1 (en) 2007-09-13
DK2436685T3 (en) 2015-09-14
NO20072283L (no) 2007-06-28
SI1819706T1 (sl) 2013-01-31
US7238807B2 (en) 2007-07-03
US20070213534A1 (en) 2007-09-13
UY29233A1 (es) 2006-07-31
PE20090488A1 (es) 2009-05-27
US20070219369A1 (en) 2007-09-20
BRPI0518601A2 (pt) 2008-11-25
KR101395591B1 (ko) 2014-05-16
PT1819706E (pt) 2012-12-06
EP2436685B1 (de) 2015-07-01
KR20070092252A (ko) 2007-09-12
IL183568A (en) 2015-02-26
JP2008521861A (ja) 2008-06-26
SG141461A1 (en) 2008-04-28
ES2548680T3 (es) 2015-10-20
EA012624B1 (ru) 2009-10-30
HRP20120980T1 (hr) 2012-12-31
US20070213529A1 (en) 2007-09-13
UA89390C2 (ru) 2010-01-25
ES2395829T3 (es) 2013-02-15
EP1819706A1 (de) 2007-08-22
IL183568A0 (en) 2007-09-20
JP5164574B2 (ja) 2013-03-21

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