HK1078075A1 - Process for preparing indolinone derivatives - Google Patents

Process for preparing indolinone derivatives

Info

Publication number
HK1078075A1
HK1078075A1 HK05109991A HK05109991A HK1078075A1 HK 1078075 A1 HK1078075 A1 HK 1078075A1 HK 05109991 A HK05109991 A HK 05109991A HK 05109991 A HK05109991 A HK 05109991A HK 1078075 A1 HK1078075 A1 HK 1078075A1
Authority
HK
Hong Kong
Prior art keywords
indolinone derivatives
preparing
preparing indolinone
derivatives
indolinone
Prior art date
Application number
HK05109991A
Other languages
English (en)
Inventor
Qingwu Jin
Michael A Mauragis
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/004407 external-priority patent/WO2002066463A1/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK1078075A1 publication Critical patent/HK1078075A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HK05109991A 2002-02-15 2005-11-09 Process for preparing indolinone derivatives HK1078075A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2002/004407 WO2002066463A1 (en) 2001-02-15 2002-02-15 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US41173202P 2002-09-18 2002-09-18
PCT/US2003/004520 WO2003070725A2 (en) 2002-02-15 2003-02-14 Process for preparing indolinone derivatives

Publications (1)

Publication Number Publication Date
HK1078075A1 true HK1078075A1 (en) 2006-03-03

Family

ID=33029733

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05109991A HK1078075A1 (en) 2002-02-15 2005-11-09 Process for preparing indolinone derivatives

Country Status (16)

Country Link
US (2) US7119209B2 (xx)
EP (1) EP1476443A2 (xx)
JP (1) JP2005528344A (xx)
KR (1) KR100657110B1 (xx)
CN (1) CN1308326C (xx)
AR (1) AR041247A1 (xx)
AU (1) AU2003216282A1 (xx)
BR (1) BR0307721A (xx)
CA (1) CA2475455A1 (xx)
HK (1) HK1078075A1 (xx)
MX (1) MXPA04006992A (xx)
PL (1) PL372302A1 (xx)
RS (1) RS70904A (xx)
RU (1) RU2299209C2 (xx)
TW (1) TWI289560B (xx)
WO (1) WO2003070725A2 (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
PL372302A1 (en) * 2002-02-15 2005-07-11 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
US7452913B2 (en) * 2003-02-24 2008-11-18 Pharmacia & Upjohn Company Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
WO2005023765A1 (en) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Method for catalyzing amidation reactions by the presence of co2
RU2319702C2 (ru) * 2003-10-02 2008-03-20 Фармация Энд Апджон Компани Ллс Негигроскопическая кристаллическая малеатная соль 5-[(z)-(5-фтор-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-n-[(2s)-2-гидрокси-3-морфолин-4-илпропил]-2,4-диметил-1h-пиррол-3-карбоксамида, фармацевтическая композиция и способ лечения рака
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
US20060287381A1 (en) * 2004-11-26 2006-12-21 The Scripps Research Institute Enhanced indolinone based protein kinase inhibitors
ES2328407T3 (es) 2005-09-19 2009-11-12 Pfizer Products Incorporated Formas salinas solidas de una 2-indolinona sustituida con pirrol.
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
WO2009067686A2 (en) 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof
US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2098521A1 (en) * 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
WO2009124037A1 (en) * 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
EP2280960A1 (en) * 2008-04-16 2011-02-09 Natco Pharma Limited Novel polymorphic forms of sunitinib base
EP2313396A1 (en) 2008-06-23 2011-04-27 Natco Pharma Limited Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
WO2009156837A2 (en) * 2008-06-26 2009-12-30 Medichem, S.A. Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
KR20110036588A (ko) * 2008-07-24 2011-04-07 테바 파마슈티컬 인더스트리즈 리미티드 수니티닙 아세테이트 및 이의 다형을 통한 수니티닙 말레이트의 제조 방법
JP2012500838A (ja) * 2008-08-25 2012-01-12 ジェネリクス・（ユーケー）・リミテッド スニチニブの新規な多形およびその調製方法
AU2009286520A1 (en) * 2008-08-25 2010-03-04 Generics [Uk] Limited Crystalline form of sunitinib and processes for its preparation
WO2011004200A1 (en) 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
CN102858739A (zh) 2010-03-10 2013-01-02 斯索恩有限公司 酰胺化吡咯甲酸酯化合物的方法
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
US8846953B2 (en) 2010-11-01 2014-09-30 Scinopharm Taiwan, Ltd. Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
CN103945696B (zh) * 2011-04-08 2016-06-29 贝达医药公司 新颖吲哚啉酮蛋白激酶抑制剂
MX359257B (es) 2012-05-04 2018-09-19 Pfizer Antígenos asociados a próstata y regímenes de inmunoterapia basados en vacuna.
KR102006527B1 (ko) 2013-11-01 2019-08-02 화이자 인코포레이티드 전립선-연관 항원의 발현을 위한 벡터
CN104744442B (zh) * 2013-12-25 2019-05-28 江苏豪森药业集团有限公司 苹果酸舒尼替尼的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
CA2282439C (en) 1997-03-05 2010-05-04 Sugen, Inc. Formulations for hydrophobic pharmaceutical agents
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6133305A (en) 1997-09-26 2000-10-17 Sugen, Inc. 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
AU3363599A (en) 1998-03-26 1999-10-18 Max-Planck Institut Fur Biochemie Heterocyclic families of compounds for the modulation of tyrosine protein kinase
DK1255536T3 (da) 1999-12-22 2006-10-30 Sugen Inc Indolinonderivater til modulation af c-kit-tyrosinproteinkinase
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
PL372302A1 (en) * 2002-02-15 2005-07-11 Pharmacia & Upjohn Company Process for preparing indolinone derivatives

Also Published As

Publication number Publication date
JP2005528344A (ja) 2005-09-22
CN1671693A (zh) 2005-09-21
WO2003070725A3 (en) 2004-01-15
AU2003216282A1 (en) 2003-09-09
WO2003070725A2 (en) 2003-08-28
RU2299209C2 (ru) 2007-05-20
AR041247A1 (es) 2005-05-11
RS70904A (xx) 2006-10-27
TW200410958A (en) 2004-07-01
MXPA04006992A (es) 2004-11-10
KR20040081203A (ko) 2004-09-20
CA2475455A1 (en) 2003-08-28
US7119209B2 (en) 2006-10-10
RU2004124711A (ru) 2006-01-20
EP1476443A2 (en) 2004-11-17
CN1308326C (zh) 2007-04-04
BR0307721A (pt) 2005-01-25
KR100657110B1 (ko) 2006-12-12
TWI289560B (en) 2007-11-11
US20050171357A1 (en) 2005-08-04
PL372302A1 (en) 2005-07-11
US20030229229A1 (en) 2003-12-11

Similar Documents

Publication Publication Date Title
HK1078075A1 (en) Process for preparing indolinone derivatives
IL195011A0 (en) Process for preparing piperidine derivatives
IL174029A0 (en) Process for preparing 2-oxo-1-pyrrolidine derivatives
IL165985A0 (en) Process for preparing pyrrolotriazine derivatives
PT1720832E (pt) Processo de preparação de derivados de 4-cetoprolina n-protegidos
IL183568A (en) Process for making 7,8-dihydro-5 h-patridine-6-onh
IL169879A0 (en) Process for preparing pyrrolotriazine derivatives
IL178233A0 (en) Process for producing 5-hydroxy-4-thiomethylpyrazole derivatives
HK1078863A1 (en) Process for preparing (s)-pantoprazole
IL172444A0 (en) Process for preparing 3-acylaminobenzofuran-2-carboxylic acid derivative
AU2003261774A1 (en) PROCESS FOR PRODUCING L-Alpha-METHYLCYSTEINE DERIVATIVE
SG137677A1 (en) Improved process for preparing polyalkenylsuccinimides
HK1086008A1 (en) Process for preparing substituted 5-amino-pyrazolo-Ä4,3-eÜ-1,2,4-triazoloÄ1,5-cÜpyrimidines
SG115596A1 (en) Process for preparing tert-butanol
EP1633694A4 (en) SUBSTITUTED INDOLE AND METHOD FOR THE PRODUCTION OF SUBSTITUTED INDOLE
AU2003218704A8 (en) Process for preparing 2-aminoindan derivatives
IL178069A0 (en) Process for preparing n-aryl-piperazine derivatives
EP1507781A4 (en) METHOD OF PREPARING MAYTANSINOL
ZA200501601B (en) Process for producing indolopyrrolocarbazole derivative
IL165137A0 (en) Process for the preparation of thioalkylamine derivatives
AU2003260942A8 (en) A process for the preparation of oxindole derivatives
IL166374A0 (en) Novel process for producing imidazoÄ1,2-bÜpyridazine derivative
MY136467A (en) Process for preparing (3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetylguanidine derivatives
IL166514A0 (en) A process for preparing hydroxyazapirone derivatives
AU2003222342A8 (en) Method for preparing $g(v)-bromoalkylcarboxylic compounds

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110214