PE20100155A1 - Derivados de urea heterociclicos y metodos de uso de los mismos-332 - Google Patents

Derivados de urea heterociclicos y metodos de uso de los mismos-332

Info

Publication number
PE20100155A1
PE20100155A1 PE2009000774A PE2009000774A PE20100155A1 PE 20100155 A1 PE20100155 A1 PE 20100155A1 PE 2009000774 A PE2009000774 A PE 2009000774A PE 2009000774 A PE2009000774 A PE 2009000774A PE 20100155 A1 PE20100155 A1 PE 20100155A1
Authority
PE
Peru
Prior art keywords
alkyl
dihydroquinolin
pyridin
oxo
carboxyl
Prior art date
Application number
PE2009000774A
Other languages
English (en)
Inventor
Pamela Hill
John Irvin Manchester
Brian Sherer
Allison Laura Choy
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40823415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100155(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20100155A1 publication Critical patent/PE20100155A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE FORMULA (I'), DONDE ANILLO A SE ENCUENTRA UNIDO A UNO DE LOS ATOMOS DE C INDICADOS COMO "*"; X ES N, CH, CR4; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ENTRE OTROS; R3 ES CARBOCICLILO C3-C14, HETEROCICLILO, ENTRE OTROS; R4 Y R15 SON CDA UNO HALO, NO2, CN, ENTRE OTROS; R5' ES OH, ALCOXI C1-C6, CICLOALCOXI C1-C6, ENTRE OTROS; R6' ES H, ALQUILO C1-C6, ALQUILSULFANILO C1-C6, ENTRE OTROS; R13 H, HALO, NO2, ENTRE OTROS; m ES 0-1; p ES 0-2. SON COMPUESTOS SELECCIONADOS: ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(TRIFLUOROMETIL)TIAZOL-2-IL)PIRIDIN-3-IL)-1-(2-METOXIETIL)-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(FENILTIAZOL-2-IL)PIRIDIN-3-IL)-1-(2-METOXIETIL)-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(TRIFLUOROMETIL)TIAZOL-2-IL)PIRIDIN-3-IL)-4-OXO-1-(3-(2-OXOPIRROLIDIN-1-IL)-PROPIL)-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A SU PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ADN GIRASA Y/O LA TOPOISOMERASA IV, UTLES PARA EL TRATAMIENTO DE NEUMONIA NOSOCOMIAL, OTITIS MEDIA AGUDA, OSTEOMIELITIS
PE2009000774A 2008-06-04 2009-06-04 Derivados de urea heterociclicos y metodos de uso de los mismos-332 PE20100155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5873608P 2008-06-04 2008-06-04

Publications (1)

Publication Number Publication Date
PE20100155A1 true PE20100155A1 (es) 2010-03-25

Family

ID=40823415

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000774A PE20100155A1 (es) 2008-06-04 2009-06-04 Derivados de urea heterociclicos y metodos de uso de los mismos-332

Country Status (23)

Country Link
US (1) US8283361B2 (es)
EP (1) EP2300463A1 (es)
JP (1) JP2011522026A (es)
KR (1) KR20110014710A (es)
CN (1) CN102105469A (es)
AR (1) AR072045A1 (es)
AU (1) AU2009254930A1 (es)
BR (1) BRPI0915471A2 (es)
CA (1) CA2725568A1 (es)
CL (1) CL2009001349A1 (es)
CO (1) CO6382176A2 (es)
CR (1) CR11825A (es)
DO (1) DOP2010000373A (es)
EA (1) EA201001858A1 (es)
EC (1) ECSP10010664A (es)
IL (1) IL209503A0 (es)
MX (1) MX2010013310A (es)
PE (1) PE20100155A1 (es)
SV (1) SV2010003752A (es)
TW (1) TW201000475A (es)
UY (1) UY31864A (es)
WO (1) WO2009147433A1 (es)
ZA (1) ZA201008610B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
TW201102065A (en) * 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
UY32694A (es) * 2009-06-08 2011-01-31 Astrazeneca Ab Derivados heterocíclicos de urea y métodos de uso de los mismos
JP2013523715A (ja) 2010-03-31 2013-06-17 アクテリオン ファーマシューティカルズ リミテッド イソキノリン−３−イル尿素誘導体
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
CN105067814A (zh) * 2015-07-24 2015-11-18 中国科学院成都生物研究所 解旋酶水解atp活性测定方法
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
WO2018074880A2 (ko) * 2016-10-20 2018-04-26 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
EP3604281A4 (en) 2017-03-24 2020-08-19 Taisho Pharmaceutical Co., Ltd. 2 (1H) -CHINOLINONE DERIVATIVE
CN111808089B (zh) * 2019-04-10 2023-04-11 四川大学华西医院 一种治疗糖尿病的药物依格列净或其衍生物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0589985A1 (en) 1991-06-21 1994-04-06 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
ES2331250T3 (es) 2000-12-15 2009-12-28 Vertex Pharmaceuticals Incorporated Inhibidores de la girasa bacteriana y usos de los mismos.
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
CN101171247A (zh) * 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US8022816B2 (en) 2005-03-21 2011-09-20 Vela Systems, Inc. System and method for field management using radio frequency tags
US7569907B2 (en) 2005-03-28 2009-08-04 Cooper Technologies Company Hybrid chip fuse assembly having wire leads and fabrication method therefor
KR20070119032A (ko) 2005-04-13 2007-12-18 코닌클리케 필립스 일렉트로닉스 엔.브이. 위상 변조 이전에 워터마킹을 통한 인코딩
US20080312211A1 (en) * 2005-12-23 2008-12-18 Astrazeneca Ab Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154
DE102006012337B3 (de) 2006-03-17 2007-11-29 Amphenol-Tuchel Electronics Gmbh Elektrischer Steckverbinder
EP2102199B1 (en) * 2006-12-04 2011-04-27 AstraZeneca AB Antibacterial polycyclic urea compounds
CN201038186Y (zh) 2007-03-08 2008-03-19 鹤山丽得电子实业有限公司 一种大功率led
TW200940537A (en) 2008-02-26 2009-10-01 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2009110688A2 (ko) 2008-03-06 2009-09-11 Jang Gum Sik 태양광 발전 장치
UY32694A (es) * 2009-06-08 2011-01-31 Astrazeneca Ab Derivados heterocíclicos de urea y métodos de uso de los mismos

Also Published As

Publication number Publication date
AR072045A1 (es) 2010-08-04
CL2009001349A1 (es) 2010-12-31
EA201001858A1 (ru) 2011-08-30
JP2011522026A (ja) 2011-07-28
ECSP10010664A (es) 2011-01-31
IL209503A0 (en) 2011-01-31
WO2009147433A1 (en) 2009-12-10
MX2010013310A (es) 2011-03-01
CO6382176A2 (es) 2012-02-15
KR20110014710A (ko) 2011-02-11
CR11825A (es) 2011-02-04
US20100190745A1 (en) 2010-07-29
EP2300463A1 (en) 2011-03-30
AU2009254930A1 (en) 2009-12-10
BRPI0915471A2 (pt) 2017-06-27
SV2010003752A (es) 2011-04-14
CN102105469A (zh) 2011-06-22
US8283361B2 (en) 2012-10-09
ZA201008610B (en) 2012-08-29
UY31864A (es) 2010-01-29
DOP2010000373A (es) 2011-01-15
CA2725568A1 (en) 2009-12-10
TW201000475A (en) 2010-01-01

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