PE20100155A1 - Derivados de urea heterociclicos y metodos de uso de los mismos-332 - Google Patents
Derivados de urea heterociclicos y metodos de uso de los mismos-332Info
- Publication number
- PE20100155A1 PE20100155A1 PE2009000774A PE2009000774A PE20100155A1 PE 20100155 A1 PE20100155 A1 PE 20100155A1 PE 2009000774 A PE2009000774 A PE 2009000774A PE 2009000774 A PE2009000774 A PE 2009000774A PE 20100155 A1 PE20100155 A1 PE 20100155A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dihydroquinolin
- pyridin
- oxo
- carboxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE FORMULA (I'), DONDE ANILLO A SE ENCUENTRA UNIDO A UNO DE LOS ATOMOS DE C INDICADOS COMO "*"; X ES N, CH, CR4; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ENTRE OTROS; R3 ES CARBOCICLILO C3-C14, HETEROCICLILO, ENTRE OTROS; R4 Y R15 SON CDA UNO HALO, NO2, CN, ENTRE OTROS; R5' ES OH, ALCOXI C1-C6, CICLOALCOXI C1-C6, ENTRE OTROS; R6' ES H, ALQUILO C1-C6, ALQUILSULFANILO C1-C6, ENTRE OTROS; R13 H, HALO, NO2, ENTRE OTROS; m ES 0-1; p ES 0-2. SON COMPUESTOS SELECCIONADOS: ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(TRIFLUOROMETIL)TIAZOL-2-IL)PIRIDIN-3-IL)-1-(2-METOXIETIL)-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(FENILTIAZOL-2-IL)PIRIDIN-3-IL)-1-(2-METOXIETIL)-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ACIDO 6-(6-(3-ETILUREIDO)-4-(4-(TRIFLUOROMETIL)TIAZOL-2-IL)PIRIDIN-3-IL)-4-OXO-1-(3-(2-OXOPIRROLIDIN-1-IL)-PROPIL)-1,4-DIHIDROQUINOLIN-3-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A SU PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ADN GIRASA Y/O LA TOPOISOMERASA IV, UTLES PARA EL TRATAMIENTO DE NEUMONIA NOSOCOMIAL, OTITIS MEDIA AGUDA, OSTEOMIELITIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5873608P | 2008-06-04 | 2008-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20100155A1 true PE20100155A1 (es) | 2010-03-25 |
Family
ID=40823415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000774A PE20100155A1 (es) | 2008-06-04 | 2009-06-04 | Derivados de urea heterociclicos y metodos de uso de los mismos-332 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8283361B2 (es) |
EP (1) | EP2300463A1 (es) |
JP (1) | JP2011522026A (es) |
KR (1) | KR20110014710A (es) |
CN (1) | CN102105469A (es) |
AR (1) | AR072045A1 (es) |
AU (1) | AU2009254930A1 (es) |
BR (1) | BRPI0915471A2 (es) |
CA (1) | CA2725568A1 (es) |
CL (1) | CL2009001349A1 (es) |
CO (1) | CO6382176A2 (es) |
CR (1) | CR11825A (es) |
DO (1) | DOP2010000373A (es) |
EA (1) | EA201001858A1 (es) |
EC (1) | ECSP10010664A (es) |
IL (1) | IL209503A0 (es) |
MX (1) | MX2010013310A (es) |
PE (1) | PE20100155A1 (es) |
SV (1) | SV2010003752A (es) |
TW (1) | TW201000475A (es) |
UY (1) | UY31864A (es) |
WO (1) | WO2009147433A1 (es) |
ZA (1) | ZA201008610B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006088246A1 (ja) * | 2005-02-18 | 2006-08-24 | Takeda Pharmaceutical Company Limited | Gpr34受容体機能調節剤 |
TW201102065A (en) * | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
US20100317624A1 (en) * | 2009-06-08 | 2010-12-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
KR20130012072A (ko) | 2010-03-31 | 2013-01-31 | 액테리온 파마슈티칼 리미티드 | 항박테리아성 이소퀴놀린-3-일우레아 유도체 |
AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
CN105067814A (zh) * | 2015-07-24 | 2015-11-18 | 中国科学院成都生物研究所 | 解旋酶水解atp活性测定方法 |
US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
WO2018074880A2 (ko) * | 2016-10-20 | 2018-04-26 | 한국화학연구원 | 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물 |
RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
CN111808089B (zh) * | 2019-04-10 | 2023-04-11 | 四川大学华西医院 | 一种治疗糖尿病的药物依格列净或其衍生物的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993000342A1 (en) | 1991-06-21 | 1993-01-07 | Boehringer Mannheim Italia S.P.A. | 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract |
IL156031A0 (en) | 2000-12-15 | 2003-12-23 | Vertex Pharma | Fused heterocyclic derivatives and pharmaceutical compositions containing the same |
AR042956A1 (es) | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
US20080269214A1 (en) * | 2005-03-04 | 2008-10-30 | Astrazeneca Ab | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors |
US8022816B2 (en) | 2005-03-21 | 2011-09-20 | Vela Systems, Inc. | System and method for field management using radio frequency tags |
US7569907B2 (en) | 2005-03-28 | 2009-08-04 | Cooper Technologies Company | Hybrid chip fuse assembly having wire leads and fabrication method therefor |
KR20070119032A (ko) | 2005-04-13 | 2007-12-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 위상 변조 이전에 워터마킹을 통한 인코딩 |
WO2007071965A2 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines |
DE102006012337B3 (de) | 2006-03-17 | 2007-11-29 | Amphenol-Tuchel Electronics Gmbh | Elektrischer Steckverbinder |
ES2363178T3 (es) * | 2006-12-04 | 2011-07-26 | Astrazeneca Ab | Compuestos de urea policíclicos antibacterianos. |
CN201038186Y (zh) | 2007-03-08 | 2008-03-19 | 鹤山丽得电子实业有限公司 | 一种大功率led |
TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
WO2009110688A2 (ko) | 2008-03-06 | 2009-09-11 | Jang Gum Sik | 태양광 발전 장치 |
US20100317624A1 (en) * | 2009-06-08 | 2010-12-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
-
2009
- 2009-06-03 CN CN2009801294194A patent/CN102105469A/zh active Pending
- 2009-06-03 AU AU2009254930A patent/AU2009254930A1/en not_active Abandoned
- 2009-06-03 EP EP09757805A patent/EP2300463A1/en not_active Withdrawn
- 2009-06-03 MX MX2010013310A patent/MX2010013310A/es not_active Application Discontinuation
- 2009-06-03 CA CA2725568A patent/CA2725568A1/en not_active Abandoned
- 2009-06-03 KR KR1020117000030A patent/KR20110014710A/ko not_active Application Discontinuation
- 2009-06-03 JP JP2011512216A patent/JP2011522026A/ja active Pending
- 2009-06-03 WO PCT/GB2009/050611 patent/WO2009147433A1/en active Application Filing
- 2009-06-03 CL CL2009001349A patent/CL2009001349A1/es unknown
- 2009-06-03 BR BRPI0915471A patent/BRPI0915471A2/pt not_active IP Right Cessation
- 2009-06-03 US US12/477,781 patent/US8283361B2/en not_active Expired - Fee Related
- 2009-06-03 UY UY0001031864A patent/UY31864A/es not_active Application Discontinuation
- 2009-06-03 EA EA201001858A patent/EA201001858A1/ru unknown
- 2009-06-03 TW TW098118462A patent/TW201000475A/zh unknown
- 2009-06-04 PE PE2009000774A patent/PE20100155A1/es not_active Application Discontinuation
- 2009-06-04 AR ARP090102012A patent/AR072045A1/es unknown
-
2010
- 2010-11-22 IL IL209503A patent/IL209503A0/en unknown
- 2010-11-30 ZA ZA2010/08610A patent/ZA201008610B/en unknown
- 2010-12-03 DO DO2010000373A patent/DOP2010000373A/es unknown
- 2010-12-06 SV SV2010003752A patent/SV2010003752A/es not_active Application Discontinuation
- 2010-12-06 CR CR11825A patent/CR11825A/es not_active Application Discontinuation
- 2010-12-07 EC EC2010010664A patent/ECSP10010664A/es unknown
- 2010-12-22 CO CO10160874A patent/CO6382176A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA201001858A1 (ru) | 2011-08-30 |
DOP2010000373A (es) | 2011-01-15 |
CR11825A (es) | 2011-02-04 |
KR20110014710A (ko) | 2011-02-11 |
AU2009254930A1 (en) | 2009-12-10 |
CN102105469A (zh) | 2011-06-22 |
JP2011522026A (ja) | 2011-07-28 |
ECSP10010664A (es) | 2011-01-31 |
CL2009001349A1 (es) | 2010-12-31 |
UY31864A (es) | 2010-01-29 |
IL209503A0 (en) | 2011-01-31 |
BRPI0915471A2 (pt) | 2017-06-27 |
CA2725568A1 (en) | 2009-12-10 |
AR072045A1 (es) | 2010-08-04 |
WO2009147433A1 (en) | 2009-12-10 |
EP2300463A1 (en) | 2011-03-30 |
US8283361B2 (en) | 2012-10-09 |
US20100190745A1 (en) | 2010-07-29 |
CO6382176A2 (es) | 2012-02-15 |
MX2010013310A (es) | 2011-03-01 |
ZA201008610B (en) | 2012-08-29 |
SV2010003752A (es) | 2011-04-14 |
TW201000475A (en) | 2010-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |