EA200901379A1 - Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа - Google Patents

Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа

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Publication number
EA200901379A1
EA200901379A1 EA200901379A EA200901379A EA200901379A1 EA 200901379 A1 EA200901379 A1 EA 200901379A1 EA 200901379 A EA200901379 A EA 200901379A EA 200901379 A EA200901379 A EA 200901379A EA 200901379 A1 EA200901379 A1 EA 200901379A1
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EA
Eurasian Patent Office
Prior art keywords
derivatives
subtiles
modulators
nicotinic acid
metabotropic glutamate
Prior art date
Application number
EA200901379A
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English (en)
Inventor
Ральф Глаттхар
Давид Каркаше
Original Assignee
Новартис Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38654771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200901379(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200901379A1 publication Critical patent/EA200901379A1/ru

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к новым производным бензимидазола, их приготовлению, использованию в качестве лекарственных препаратов, а также фармацевтическим композициям, их содержащим, где соединения составлены по формуле (I), в которой заместители определены согласно п.1, а также их соли, сольваты, гидраты и N-оксиды.
EA200901379A 2007-04-19 2008-04-17 Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа EA200901379A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07106537 2007-04-19
PCT/EP2008/054682 WO2008128968A1 (en) 2007-04-19 2008-04-17 Nicotinic acid derivatives as modulators of metabotropic glutamate receptor-5

Publications (1)

Publication Number Publication Date
EA200901379A1 true EA200901379A1 (ru) 2010-04-30

Family

ID=38654771

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Application Number Title Priority Date Filing Date
EA200901379A EA200901379A1 (ru) 2007-04-19 2008-04-17 Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа

Country Status (15)

Country Link
US (1) US20090105266A1 (ru)
EP (1) EP2146969A1 (ru)
JP (1) JP2010524892A (ru)
KR (1) KR20090130141A (ru)
CN (1) CN101679299A (ru)
AR (1) AR068072A1 (ru)
AU (1) AU2008240790A1 (ru)
BR (1) BRPI0810653A2 (ru)
CA (1) CA2682676A1 (ru)
CL (1) CL2008001114A1 (ru)
EA (1) EA200901379A1 (ru)
MX (1) MX2009011208A (ru)
PE (1) PE20090074A1 (ru)
TW (1) TW200904425A (ru)
WO (1) WO2008128968A1 (ru)

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JP2010524892A (ja) 2010-07-22
MX2009011208A (es) 2009-10-30
CA2682676A1 (en) 2008-10-30
AR068072A1 (es) 2009-11-04
US20090105266A1 (en) 2009-04-23
KR20090130141A (ko) 2009-12-17
CL2008001114A1 (es) 2008-12-19
WO2008128968A1 (en) 2008-10-30
BRPI0810653A2 (pt) 2014-11-04
EP2146969A1 (en) 2010-01-27
PE20090074A1 (es) 2009-03-02
TW200904425A (en) 2009-02-01
AU2008240790A1 (en) 2008-10-30
CN101679299A (zh) 2010-03-24

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