AR088729A1 - Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica - Google Patents
Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceuticaInfo
- Publication number
- AR088729A1 AR088729A1 ARP120101017A ARP120101017A AR088729A1 AR 088729 A1 AR088729 A1 AR 088729A1 AR P120101017 A ARP120101017 A AR P120101017A AR P120101017 A ARP120101017 A AR P120101017A AR 088729 A1 AR088729 A1 AR 088729A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- methyl
- halogen
- carbamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados de 3-ureidoisoquinolin-8-ilo de la fórmula (1) útiles en prevención o tratamiento de enfermedades bacterianas. Reivindicación 1: Un compuesto de la fórmula (1) en donde R¹ es alquilo C₁₋₃, haloalquilo C₂₋₃ o ciclopropilo; R² es H, halógeno, piridazin-4-ilo, pirimidin-5-ilo o un grupo que tiene la fórmula (2), (3) ó (4), en donde Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente H o metilo, o cada uno de Rˣ y Rᶻ es H y Rʸ es halógeno, ciano, alquilo C₂₋₄, alcoxi C₁₋₄, amino, hidroxi, hidroxi-alquilo C₁₋₃, trifluorometilo, carbamoilo, carbamoil-alquilo C₁₋₂, (metilcarbamoil)-alquilo C₁₋₂, (dimetilcarbamoil)-alquilo C₁₋₂, terc-butoxicarbonilmetilo, ciclopropilo, pirrolidin-1-ilo, piperidin-1-ilo, morfolin-1-ilo o 1-morfolinometilo, o Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente halógeno, o Rˣ es metilo, Rʸ es metilo o halógeno y Rᶻ es H, o Rˣ es metilo o halógeno, Rʸ es H y Rᶻ es metilo o halógeno, o Rˣ es metilo o halógeno y cada uno de Rʸ y Rᶻ es H; Rˣ² es H, amino o hidroximetilo; Rˣ³ es hidroxi, carboxi, carbamoilo, hidroximetilo o aminometilo, Rʸ³ es H y Rᶻ³ es H o cada uno de Rˣ³ y Rᶻ³ es H y Rʸ³ es hidroxi, acetamidometilo, (dimetilamino)metilo, carboximetilo, carbamoilo o aminometilo, o cada uno de Rˣ³ y Rʸ³ es H y Rᶻ³ es hidroxi; R³ es alquilo C₁₋₄, alquinilo C₂₋₄, amino-alquilo C₁₋₃, carbamoil-alquilo C₁₋₃, (metilcarbamoil)-alquilo C₁₋₃, alcoxi C₁₋₄, haloalcoxi C₁₋₄, alquiniloxi C₃₋₄, (4-hidroxibut-2-en-1-il)oxi, (4-aminobut-2-en-1-il)oxi, dimetilamino-alcoxi C₂₋₃, carbamoil-alcoxi C₁₋₃, alquilamino C₁₋₃, cicloalquilo C₃₋₆, cicloalquil C₃₋₆-alquilo C₁₋₄, cicloalquil C₃₋₆-alcoxi C₁₋₄, hidroxi-alquilo C₁₋₃, hidroxi-alcoxi C₂₋₃, alcoxi C₁₋₃-alquilo C₁₋₃, alcoxi C₁₋₃-alcoxi C₁₋₃, carboxi-alquilo C₁₋₃, carboxi-alcoxi C₁₋₃, alcoxicarbonil C₁₋₂-alcoxi C₁₋₃, arilo, heteroarilo C₅₋₆, bencilo, benciloxi, 2-cianoetoxi, 2,3-dihidroxipropoxi, 3,4-dihidroxibutoxi, -CH₂Rᵃ, -CH₂CH₂Rᵇ, -(CH₂)ₙ-C(O)O-Rᵈ, (CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -O-(CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -(CH₂)ₙ-Rᵉ o -O-(CH₂)ₙ-Rᵉ; n es 1, 2 ó 3; Rᵃ es ciano, acetilamino, N,N-dimetilamino; y Rᵇ es ciano; Rᶜ es H o metilo; Rᵈ es alquilo C₁₋₄; Rᵉ es pirrolidin-1-ilo, piperidin-1-ilo, piperidin-3-ilo, morfolin-1-ilo, 2-oxopirrolidin-1-ilo, 5-oxopirrolidin-2-ilo, 2,5-dioxopirrolidin-1-ilo, 2-oxoimidazoliden-1-ilo, 4-(terc-butoxicarbonil)piperazin-1-ilo, 4-(aminometil)ciclohexilo o heteroarilo C₅₋₆; R⁴ es H o metilo; o una sal de dicho compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051320 | 2011-03-29 | ||
| IB2011054063 | 2011-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088729A1 true AR088729A1 (es) | 2014-07-02 |
Family
ID=45976978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101017A AR088729A1 (es) | 2011-03-29 | 2012-03-27 | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8889676B2 (es) |
| EP (1) | EP2691373A1 (es) |
| JP (1) | JP2014512352A (es) |
| KR (1) | KR20140019423A (es) |
| CN (1) | CN103476756A (es) |
| AR (1) | AR088729A1 (es) |
| AU (1) | AU2012235706A1 (es) |
| BR (1) | BR112013024899A2 (es) |
| CA (1) | CA2828423A1 (es) |
| IL (1) | IL228486A0 (es) |
| MA (1) | MA35048B1 (es) |
| MX (1) | MX2013011253A (es) |
| RU (1) | RU2013147875A (es) |
| TW (1) | TW201249801A (es) |
| WO (1) | WO2012131588A1 (es) |
| ZA (1) | ZA201308049B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110446699A (zh) | 2017-03-24 | 2019-11-12 | 大正制药株式会社 | 2（1h）-喹啉酮衍生物 |
| US20230138901A1 (en) | 2019-12-24 | 2023-05-04 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Compound having khk inhibitory effect |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US6958333B1 (en) | 1999-07-26 | 2005-10-25 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
| JP4803935B2 (ja) * | 1999-10-08 | 2011-10-26 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | Ｆａｂｉ阻害剤 |
| ES2331250T3 (es) | 2000-12-15 | 2009-12-28 | Vertex Pharmaceuticals Incorporated | Inhibidores de la girasa bacteriana y usos de los mismos. |
| US6831068B2 (en) | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| PL374191A1 (en) * | 2002-06-13 | 2005-10-03 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections |
| US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| EP1737459B1 (en) | 2004-03-19 | 2009-08-05 | Warner-Lambert Company LLC | Imidazopyridine and imidazopyrimidine derivatives as antibacterial agents |
| US7524860B2 (en) | 2004-10-07 | 2009-04-28 | Pfizer Inc. | Antibacterial agents |
| US20090239841A1 (en) | 2004-10-27 | 2009-09-24 | Hutchison Alan J | Diaryl Ureas as CB1 Antagonists |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| CN1958568B (zh) * | 2005-11-03 | 2011-04-13 | 中国科学院上海药物研究所 | 一类预防或治疗幽门螺杆菌感染化合物、其制法和用途 |
| JP2009514894A (ja) | 2005-11-07 | 2009-04-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | ジャイレース阻害剤としてのベンズイミダゾール誘導体 |
| CA2651072A1 (en) | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| WO2007146230A2 (en) | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
| UA96964C2 (ru) | 2006-12-04 | 2011-12-26 | Астразенека Аб | Соединения полициклической мочевины с антибактериальными свойствами |
| WO2008082487A2 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
| WO2008141010A2 (en) * | 2007-05-11 | 2008-11-20 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| WO2009027732A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | 5-6-bicyclic heteroaromatic compounds with antibacterial activity |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| MX2010007391A (es) | 2008-01-04 | 2010-10-05 | Abbott Lab | Antagonistas de trpa1. |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
| EP2300463A1 (en) | 2008-06-04 | 2011-03-30 | AstraZeneca AB | Heterocyclic urea derivatives for the treatment of bacterial infections |
| CL2009001345A1 (es) | 2008-06-04 | 2010-06-11 | Astrazeneca Ab | Compuestos derivados de 1-piridin-2-il-urea y 1-pirimidin-2-il-urea sustituidos, inhibidores de adn girasa y topoisomerasa iv; composicion farmaceutica; y su uso en tratamiento de infecciones bacterianas como neumonia adquirida intrahospitalariamente, infecciones a la piel, bronquitis, sinusitis, entre otras enfermedades. |
| BRPI0913300A2 (pt) | 2008-06-04 | 2018-05-22 | Astrazeneca Ab | composto, processo para o preparo e uso do mesmo, método de tratamento de infecção bacteriana em um animal, e, composição farmacêutica. |
| US20110166088A1 (en) | 2008-06-25 | 2011-07-07 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| UY32694A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Derivados heterocíclicos de urea y métodos de uso de los mismos |
| WO2011024004A1 (en) | 2009-08-26 | 2011-03-03 | Astrazeneca Ab | Heterocyclic urea derivatives useful for treatment of bacterial infection |
| JP2013523715A (ja) | 2010-03-31 | 2013-06-17 | アクテリオン ファーマシューティカルズ リミテッド | イソキノリン−３−イル尿素誘導体 |
-
2012
- 2012-03-27 AR ARP120101017A patent/AR088729A1/es not_active Application Discontinuation
- 2012-03-28 RU RU2013147875/04A patent/RU2013147875A/ru not_active Application Discontinuation
- 2012-03-28 TW TW101110929A patent/TW201249801A/zh unknown
- 2012-03-28 KR KR1020137028588A patent/KR20140019423A/ko not_active Application Discontinuation
- 2012-03-28 AU AU2012235706A patent/AU2012235706A1/en not_active Abandoned
- 2012-03-28 US US14/009,093 patent/US8889676B2/en not_active Expired - Fee Related
- 2012-03-28 WO PCT/IB2012/051473 patent/WO2012131588A1/en active Application Filing
- 2012-03-28 CN CN2012800151068A patent/CN103476756A/zh active Pending
- 2012-03-28 CA CA2828423A patent/CA2828423A1/en not_active Abandoned
- 2012-03-28 EP EP12715438.3A patent/EP2691373A1/en not_active Withdrawn
- 2012-03-28 MX MX2013011253A patent/MX2013011253A/es not_active Application Discontinuation
- 2012-03-28 JP JP2014501786A patent/JP2014512352A/ja active Pending
- 2012-03-28 MA MA36339A patent/MA35048B1/fr unknown
- 2012-03-28 BR BR112013024899A patent/BR112013024899A2/pt not_active IP Right Cessation
-
2013
- 2013-09-17 IL IL228486A patent/IL228486A0/en unknown
- 2013-10-29 ZA ZA2013/08049A patent/ZA201308049B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103476756A (zh) | 2013-12-25 |
| US20140038961A1 (en) | 2014-02-06 |
| MX2013011253A (es) | 2013-10-17 |
| RU2013147875A (ru) | 2015-05-10 |
| IL228486A0 (en) | 2013-12-31 |
| AU2012235706A1 (en) | 2013-11-14 |
| WO2012131588A1 (en) | 2012-10-04 |
| JP2014512352A (ja) | 2014-05-22 |
| TW201249801A (en) | 2012-12-16 |
| MA35048B1 (fr) | 2014-04-03 |
| EP2691373A1 (en) | 2014-02-05 |
| CA2828423A1 (en) | 2012-10-04 |
| BR112013024899A2 (pt) | 2016-12-20 |
| KR20140019423A (ko) | 2014-02-14 |
| ZA201308049B (en) | 2016-08-31 |
| NZ617068A (en) | 2015-05-29 |
| US8889676B2 (en) | 2014-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR089768A1 (es) | Compuestos terapeuticamente activos y sus metodos de uso | |
| EA201590450A1 (ru) | Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| EA201491329A1 (ru) | 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| ES2625256T3 (es) | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIA | |
| AR085195A1 (es) | Metodo de tratamiento de cancer | |
| MD4425C1 (ro) | Alcoxipirazoli în calitate de activatori ai guanilat-ciclazei solubile | |
| NZ607794A (en) | N-acylsulfonamide apoptosis promoters | |
| AR082101A1 (es) | Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento | |
| MY182539A (en) | Methods of treating alzheimer's disease and pharmaceutical compositions thereof | |
| NZ631419A (en) | Inhibitors of hepatitis b virus covalently closed circular dna formation and their method of use | |
| EA201591586A1 (ru) | Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| AR094784A1 (es) | Compuestos de tubulisina, métodos para obtenerlos y uso | |
| PH12014502597A1 (en) | N-substituted benzamides and their use in the treatment of pain | |
| AR080328A1 (es) | Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros | |
| BR112015009850A2 (pt) | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase | |
| EA201370166A1 (ru) | Содержащие диарилацетиленгидразид ингибиторы тирозинкиназы | |
| BR112014029016A8 (pt) | derivados de ácido 7-oxo-tiazolopiridina carbônico e seu uso no tratamento, melhora ou prevenção de uma doença viral | |
| RU2017126128A (ru) | Конденсированные бициклические соединения для лечения заболевания | |
| EA201490419A1 (ru) | Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания | |
| EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
| MX338114B (es) | Inhibidores de arginasa y sus aplicaciones terapeuticas. | |
| AR087995A1 (es) | Derivados de n-(4-{[6,7-bis(metiloxi)quinolin-4-il]oxi}fenil)-n-(4-fluorofenil)ciclopropan-1,1-dicarboxamida | |
| GEP20186880B (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
| AR084637A1 (es) | Compuestos heterociclicos apropiados para el tratamiento de la dislipidemia | |
| EA200901573A1 (ru) | Гетероарилзамещенные тиазолы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |