MA35048B1 - Dérivés de 3-uréidoisoquinoléin-8-yle - Google Patents

Dérivés de 3-uréidoisoquinoléin-8-yle

Info

Publication number
MA35048B1
MA35048B1 MA36339A MA36339A MA35048B1 MA 35048 B1 MA35048 B1 MA 35048B1 MA 36339 A MA36339 A MA 36339A MA 36339 A MA36339 A MA 36339A MA 35048 B1 MA35048 B1 MA 35048B1
Authority
MA
Morocco
Prior art keywords
yle
methyl
carbamoylalkyl
oxopyrrolidin
piperidin
Prior art date
Application number
MA36339A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Philippe Panchaud
Markus Gude
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA35048B1 publication Critical patent/MA35048B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES DÉRIVÉS DE 3-URÉIDOISOQUINOLÉIN-8-YLE DE FORMULE I, DANS LAQUELLE R1 EST ALKYLE, HALOALKYLE OU CYCLOPROPYLE; R2 EST H, HALOGÈNE, PYRIDAZIN-4-YLE, PYRIMIDIN-5-YLE OU UN GROUPE FACULTATIVEMENT SUBSTITUÉ DE PYRIDIN-3-YLE, PYRIDIN-4-YLE OU PHÉNYLE; R3 EST ALKYLE, ALCYNYLE, AMINOALKYLE, CARBAMOYLALKYLE, MÉTHYL-CARBAMOYLALKYLE, ALCOXY, HALOALCOXY, ALCYNYLOXY, (4-HYDROXYBUT-2-YN-1-YL)OXY, (4-AMINOBUT-2-YN-1-YL)OXY, DIMÉTHYLAMINOALCOXY, CARBAMOYLALCOXY, ALKYLAMINO, CYCLOALKYLE, CYCLOALKYLALKYLE, CYCLOALKYLALCOXY, HYDROXYALKYLE, HYDROXYALCOXY, ALCOXYALKYLE, ALCOXYALCOXY, CARBOXYALKYLE, CARBOXYALCOXY, ALCOXYCARBONYLALCOXY, ARYLE, HÉTÉROARYLE, BENZYLE, BENZYLOXY, 2-CYANOÉTHOXY, 2,3-DIHYDROXYPROPOXY, 3,4-DIHYDROXYBUTOXY, -CH2RA, -CH2CH2RB, -(CH2)N-C(O)O-RD, -(CH2)N-N(RC)C(O)O-RD, -O-(CH2)N-N(RC)C(O)O-RD, -(CH2)N-RE OU -O-(CH2)N-RE; RA EST CYANO, ACÉTYLAMINO OU N,N-DIMÉTHYLAMINO; RB EST CYANO OU CARBAMOYLE; RC EST H OU MÉTHYLE; RD EST ALKYLE; RE EST PYRROLIDIN-1-YLE, PIPÉRIDIN-1-YLE, PIPÉRIDIN-3-YLE, MORPHOLIN-1-YLE, 2-OXOPYRROLIDIN-1-YLE, 5-OXOPYRROLIDIN-2-YLE, 2,5-DIOXOPYRROLIDIN-1-YLE, 2-OXOIMIDAZOLIDIN-1-YLE, 4-(TERT-BUTOXY-CARBONYL)PIPÉRAZIN-1-YLE, 4-(AMINOMÉTHYL)CYCLOHEXYLE OU HÉTÉROARYLE; R4 EST H OU MÉTHYLE; ET LES SELS DE CES COMPOSÉS. CES COMPOSÉS SONT UTILES POUR LA PRÉVENTION OU LE TRAITEMENT D'INFECTIONS BACTÉRIENNES.
MA36339A 2011-03-29 2012-03-28 Dérivés de 3-uréidoisoquinoléin-8-yle MA35048B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2011051320 2011-03-29
IB2011054063 2011-09-16
PCT/IB2012/051473 WO2012131588A1 (fr) 2011-03-29 2012-03-28 Dérivés de 3-uréidoisoquinoléin-8-yle

Publications (1)

Publication Number Publication Date
MA35048B1 true MA35048B1 (fr) 2014-04-03

Family

ID=45976978

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36339A MA35048B1 (fr) 2011-03-29 2012-03-28 Dérivés de 3-uréidoisoquinoléin-8-yle

Country Status (16)

Country Link
US (1) US8889676B2 (fr)
EP (1) EP2691373A1 (fr)
JP (1) JP2014512352A (fr)
KR (1) KR20140019423A (fr)
CN (1) CN103476756A (fr)
AR (1) AR088729A1 (fr)
AU (1) AU2012235706A1 (fr)
BR (1) BR112013024899A2 (fr)
CA (1) CA2828423A1 (fr)
IL (1) IL228486A0 (fr)
MA (1) MA35048B1 (fr)
MX (1) MX2013011253A (fr)
RU (1) RU2013147875A (fr)
TW (1) TW201249801A (fr)
WO (1) WO2012131588A1 (fr)
ZA (1) ZA201308049B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2019133662A (ru) 2017-03-24 2021-04-26 Тайсо Фармасьютикал Ко., Лтд. Производное 2(1h)-хинолинона
WO2021129737A1 (fr) 2019-12-24 2021-07-01 南京明德新药研发有限公司 Composé à effet inhibiteur de khk

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Also Published As

Publication number Publication date
NZ617068A (en) 2015-05-29
US8889676B2 (en) 2014-11-18
BR112013024899A2 (pt) 2016-12-20
IL228486A0 (en) 2013-12-31
JP2014512352A (ja) 2014-05-22
TW201249801A (en) 2012-12-16
AU2012235706A1 (en) 2013-11-14
RU2013147875A (ru) 2015-05-10
KR20140019423A (ko) 2014-02-14
US20140038961A1 (en) 2014-02-06
CA2828423A1 (fr) 2012-10-04
EP2691373A1 (fr) 2014-02-05
AR088729A1 (es) 2014-07-02
CN103476756A (zh) 2013-12-25
WO2012131588A1 (fr) 2012-10-04
MX2013011253A (es) 2013-10-17
ZA201308049B (en) 2016-08-31

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