CY1108804T1 - Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης. - Google Patents

Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης.

Info

Publication number
CY1108804T1
CY1108804T1 CY20091100177T CY091100177T CY1108804T1 CY 1108804 T1 CY1108804 T1 CY 1108804T1 CY 20091100177 T CY20091100177 T CY 20091100177T CY 091100177 T CY091100177 T CY 091100177T CY 1108804 T1 CY1108804 T1 CY 1108804T1
Authority
CY
Cyprus
Prior art keywords
demethyl
amino
desoxypodophyllotoxin
desesopypophylotoxine
preparation
Prior art date
Application number
CY20091100177T
Other languages
English (en)
Inventor
Yves Guminski
Martial Grousseaud
Thierry Imbert
Original Assignee
Pierre Fabre Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament filed Critical Pierre Fabre Medicament
Publication of CY1108804T1 publication Critical patent/CY1108804T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Telephone Set Structure (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μία μέθοδο συνθέσεως της 4β-αμινο-4'-δεμεθυλ-4-δεσο-ξυποδοφυλλοτοξίνης τύπου (1), χαρακτηριζόμενη από το ότι περιλαμβάνει τα ακόλουθα διαδοχικά στάδια: a) αντίδραση, εντός ενός καθαρού ασθενούς οξέως ή εντός ενός μίγματος οξέως, νερού και οργανικού διαλύτη, χωρίς άλλο διαλύτη, σε θερμοκρασία μεγαλύτερη από τη θερμοκρασία περιβάλλοντος, θειουρίας με 4β-αλογονοακεταμιδο-4'-δεμεθυλ-4-δεσοξυποδοφυλλοτοξίνη• b) συλλογή της 4β-αμινο-4'-δεμεθυλ-4-δεσοξυποδοφυλλοτοξίνης.
CY20091100177T 2005-07-19 2009-02-18 Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης. CY1108804T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507642A FR2888849B1 (fr) 2005-07-19 2005-07-19 Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
EP06764221A EP1907396B1 (fr) 2005-07-19 2006-07-19 Procede de preparation de la 4 -amino-4'-demethyl-4-desoxypodophyllotoxine

Publications (1)

Publication Number Publication Date
CY1108804T1 true CY1108804T1 (el) 2014-04-09

Family

ID=36035759

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100177T CY1108804T1 (el) 2005-07-19 2009-02-18 Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης.

Country Status (30)

Country Link
US (2) US7932406B2 (el)
EP (1) EP1907396B1 (el)
JP (1) JP5140583B2 (el)
KR (1) KR101357664B1 (el)
CN (1) CN101223176B (el)
AT (1) ATE414707T1 (el)
AU (1) AU2006271645B2 (el)
BR (1) BRPI0613418A2 (el)
CA (1) CA2616064C (el)
CY (1) CY1108804T1 (el)
DE (1) DE602006003769D1 (el)
DK (1) DK1907396T3 (el)
ES (1) ES2317561T3 (el)
FR (1) FR2888849B1 (el)
HK (1) HK1114101A1 (el)
HR (1) HRP20090103T3 (el)
IL (1) IL188716A0 (el)
MA (1) MA29690B1 (el)
MX (1) MX2008000961A (el)
NO (1) NO20080812L (el)
NZ (1) NZ565923A (el)
PL (1) PL1907396T3 (el)
PT (1) PT1907396E (el)
RS (1) RS50782B (el)
RU (1) RU2405787C2 (el)
SI (1) SI1907396T1 (el)
TN (1) TNSN08030A1 (el)
UA (1) UA90530C2 (el)
WO (1) WO2007010007A1 (el)
ZA (1) ZA200801577B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2637886A (en) * 1950-04-06 1953-05-12 Walther Trautwein Slide fastener
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2921368B1 (fr) * 2007-09-25 2012-10-12 Pf Medicament Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR2935143B1 (fr) * 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
EP2448911A1 (en) 2009-06-29 2012-05-09 Merz Pharma GmbH & Co. KGaA Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane
EP2448909B1 (en) * 2009-06-29 2013-05-01 Merz Pharma GmbH & Co. KGaA Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane
CA2765609A1 (en) * 2009-06-29 2011-01-06 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61126095A (ja) * 1984-11-26 1986-06-13 Fuji Yakuhin Kogyo Kk 新規グルコサミン誘導体
JPS62215583A (ja) * 1986-03-14 1987-09-22 Takeda Chem Ind Ltd ピラゾリジノン誘導体およびその製造法
US5332811A (en) * 1989-09-12 1994-07-26 The University Of North Carolina At Chapel Hill Etopside analogs
WO2004073375A2 (en) 2003-02-18 2004-09-02 Ranbaxy Laboratories Limited Podophyllotoxin derivatives as antitumor agents
FR2869035B1 (fr) * 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine

Also Published As

Publication number Publication date
HRP20090103T3 (en) 2009-03-31
MA29690B1 (fr) 2008-08-01
AU2006271645A1 (en) 2007-01-25
ZA200801577B (en) 2009-01-28
UA90530C2 (uk) 2010-05-11
FR2888849A1 (fr) 2007-01-26
US7932406B2 (en) 2011-04-26
NZ565923A (en) 2010-01-29
FR2888849B1 (fr) 2007-10-05
US20110021791A1 (en) 2011-01-27
CA2616064C (fr) 2013-11-05
KR101357664B1 (ko) 2014-02-03
AU2006271645B2 (en) 2012-02-02
US8193379B2 (en) 2012-06-05
EP1907396A1 (fr) 2008-04-09
DE602006003769D1 (de) 2009-01-02
NO20080812L (no) 2008-02-14
RU2405787C2 (ru) 2010-12-10
BRPI0613418A2 (pt) 2011-01-11
WO2007010007A1 (fr) 2007-01-25
HK1114101A1 (el) 2008-10-24
TNSN08030A1 (fr) 2009-07-14
MX2008000961A (es) 2008-03-27
RU2008106100A (ru) 2009-08-27
IL188716A0 (en) 2008-08-07
DK1907396T3 (da) 2009-03-02
ES2317561T3 (es) 2009-04-16
RS50782B (sr) 2010-08-31
JP2009501764A (ja) 2009-01-22
SI1907396T1 (sl) 2009-04-30
CA2616064A1 (fr) 2007-01-25
PT1907396E (pt) 2009-02-13
PL1907396T3 (pl) 2009-04-30
CN101223176A (zh) 2008-07-16
CN101223176B (zh) 2011-06-15
JP5140583B2 (ja) 2013-02-06
KR20080036058A (ko) 2008-04-24
ATE414707T1 (de) 2008-12-15
US20090137826A1 (en) 2009-05-28
EP1907396B1 (fr) 2008-11-19

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