RS50782B - Postupak za dobijanje 4-amino-4'-demetil-4-dezoksipodofilotoksina - Google Patents

Postupak za dobijanje 4-amino-4'-demetil-4-dezoksipodofilotoksina

Info

Publication number
RS50782B
RS50782B RSP-2009/0079A RSP20090079A RS50782B RS 50782 B RS50782 B RS 50782B RS P20090079 A RSP20090079 A RS P20090079A RS 50782 B RS50782 B RS 50782B
Authority
RS
Serbia
Prior art keywords
desoxypodophyllotoxin
amino
demethyl
dmethyl
preparing
Prior art date
Application number
RSP-2009/0079A
Other languages
English (en)
Inventor
Thierry Imbert
Yves Guminski
Martial Grousseaud
Original Assignee
Pierre Fabre Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament filed Critical Pierre Fabre Medicament
Publication of RS50782B publication Critical patent/RS50782B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Telephone Set Structure (AREA)

Abstract

Postupak za sintetisanje 4β-amino-4'-demetil-4-dezoksipodofilotoksina formule Inaznačen time, što obuhvata sledeće sukcesivne korake:a) reakciju, u čistoj slaboj kiselini, bez drugog rastvarača, na temperaturi većoj od sobne temperature, tiouree sa 4β-halogenoacetamido-4'-demetil-4-dezoksipodofilotoksinom formule 3u kojoj X predstavlja atom halogena odabran iz grupe koju čine hlor, brom i jod, najbolje hlor;b) povraćaj 4(3 -amino-4'-demetil-4-dezoksipodofilotoksina.Prijava sadrži još 14 patentnih zahteva.
RSP-2009/0079A 2005-07-19 2006-07-19 Postupak za dobijanje 4-amino-4'-demetil-4-dezoksipodofilotoksina RS50782B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507642A FR2888849B1 (fr) 2005-07-19 2005-07-19 Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
PCT/EP2006/064420 WO2007010007A1 (fr) 2005-07-19 2006-07-19 PROCEDE DE PREPARATION DE LA 4β-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXINE

Publications (1)

Publication Number Publication Date
RS50782B true RS50782B (sr) 2010-08-31

Family

ID=36035759

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0079A RS50782B (sr) 2005-07-19 2006-07-19 Postupak za dobijanje 4-amino-4'-demetil-4-dezoksipodofilotoksina

Country Status (30)

Country Link
US (2) US7932406B2 (sr)
EP (1) EP1907396B1 (sr)
JP (1) JP5140583B2 (sr)
KR (1) KR101357664B1 (sr)
CN (1) CN101223176B (sr)
AT (1) ATE414707T1 (sr)
AU (1) AU2006271645B2 (sr)
BR (1) BRPI0613418A2 (sr)
CA (1) CA2616064C (sr)
CY (1) CY1108804T1 (sr)
DE (1) DE602006003769D1 (sr)
DK (1) DK1907396T3 (sr)
ES (1) ES2317561T3 (sr)
FR (1) FR2888849B1 (sr)
HK (1) HK1114101A1 (sr)
HR (1) HRP20090103T3 (sr)
IL (1) IL188716A0 (sr)
MA (1) MA29690B1 (sr)
MX (1) MX2008000961A (sr)
NO (1) NO20080812L (sr)
NZ (1) NZ565923A (sr)
PL (1) PL1907396T3 (sr)
PT (1) PT1907396E (sr)
RS (1) RS50782B (sr)
RU (1) RU2405787C2 (sr)
SI (1) SI1907396T1 (sr)
TN (1) TNSN08030A1 (sr)
UA (1) UA90530C2 (sr)
WO (1) WO2007010007A1 (sr)
ZA (1) ZA200801577B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2637886A (en) * 1950-04-06 1953-05-12 Walther Trautwein Slide fastener
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2921368B1 (fr) * 2007-09-25 2012-10-12 Pf Medicament Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR2935143B1 (fr) * 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
EP2448911A1 (en) 2009-06-29 2012-05-09 Merz Pharma GmbH & Co. KGaA Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane
EP2448909B1 (en) * 2009-06-29 2013-05-01 Merz Pharma GmbH & Co. KGaA Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane
CA2765609A1 (en) * 2009-06-29 2011-01-06 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61126095A (ja) * 1984-11-26 1986-06-13 Fuji Yakuhin Kogyo Kk 新規グルコサミン誘導体
JPS62215583A (ja) * 1986-03-14 1987-09-22 Takeda Chem Ind Ltd ピラゾリジノン誘導体およびその製造法
US5332811A (en) * 1989-09-12 1994-07-26 The University Of North Carolina At Chapel Hill Etopside analogs
WO2004073375A2 (en) 2003-02-18 2004-09-02 Ranbaxy Laboratories Limited Podophyllotoxin derivatives as antitumor agents
FR2869035B1 (fr) * 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine

Also Published As

Publication number Publication date
HRP20090103T3 (en) 2009-03-31
MA29690B1 (fr) 2008-08-01
AU2006271645A1 (en) 2007-01-25
ZA200801577B (en) 2009-01-28
UA90530C2 (uk) 2010-05-11
FR2888849A1 (fr) 2007-01-26
US7932406B2 (en) 2011-04-26
NZ565923A (en) 2010-01-29
FR2888849B1 (fr) 2007-10-05
US20110021791A1 (en) 2011-01-27
CA2616064C (fr) 2013-11-05
KR101357664B1 (ko) 2014-02-03
AU2006271645B2 (en) 2012-02-02
US8193379B2 (en) 2012-06-05
CY1108804T1 (el) 2014-04-09
EP1907396A1 (fr) 2008-04-09
DE602006003769D1 (de) 2009-01-02
NO20080812L (no) 2008-02-14
RU2405787C2 (ru) 2010-12-10
BRPI0613418A2 (pt) 2011-01-11
WO2007010007A1 (fr) 2007-01-25
HK1114101A1 (sr) 2008-10-24
TNSN08030A1 (fr) 2009-07-14
MX2008000961A (es) 2008-03-27
RU2008106100A (ru) 2009-08-27
IL188716A0 (en) 2008-08-07
DK1907396T3 (da) 2009-03-02
ES2317561T3 (es) 2009-04-16
JP2009501764A (ja) 2009-01-22
SI1907396T1 (sl) 2009-04-30
CA2616064A1 (fr) 2007-01-25
PT1907396E (pt) 2009-02-13
PL1907396T3 (pl) 2009-04-30
CN101223176A (zh) 2008-07-16
CN101223176B (zh) 2011-06-15
JP5140583B2 (ja) 2013-02-06
KR20080036058A (ko) 2008-04-24
ATE414707T1 (de) 2008-12-15
US20090137826A1 (en) 2009-05-28
EP1907396B1 (fr) 2008-11-19

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