UA102787C2 - Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм - Google Patents

Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм

Info

Publication number
UA102787C2
UA102787C2 UAA201207006A UAA201207006A UA102787C2 UA 102787 C2 UA102787 C2 UA 102787C2 UA A201207006 A UAA201207006 A UA A201207006A UA A201207006 A UAA201207006 A UA A201207006A UA 102787 C2 UA102787 C2 UA 102787C2
Authority
UA
Ukraine
Prior art keywords
ilaprazole
crystalline forms
preparing
conversion
crystalline form
Prior art date
Application number
UAA201207006A
Other languages
English (en)
Ukrainian (uk)
Inventor
Донг Эон Ким
Яае Соо Шин
Юн Эоун Ли
Кви Хиунг Чо
Сунг Тае Парк
Юнг Ву Ким
Санг Дон Нам
Хи Юн Ким
Original Assignee
Ил-Янг Фарм. Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ил-Янг Фарм. Ко., Лтд. filed Critical Ил-Янг Фарм. Ко., Лтд.
Publication of UA102787C2 publication Critical patent/UA102787C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение касается способов приготовления кристаллических форм А и В илапразола формулы 1 и преобразования этих кристаллических форм.Новые способы включают способ приготовления кристаллической формы А высокой чистоты путем получения неорганической соли илапразола или ее гидрата и нейтрализации полученной неорганической соли илапразола или ее гидрата кислотой в органическом растворителе (отдельный растворитель или смесь растворителей); способ приготовления кристаллической формы В высокой чистоты путем удаления примесей из илапразола с использованием органического растворителя (отдельный растворитель или смесь растворителей); и способ преобразования кристаллической формы А в кристаллическую форму В или кристаллической формы В в кристаллическую форму А.
UAA201207006A 2009-12-08 2010-12-08 Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм UA102787C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (ko) 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Publications (1)

Publication Number Publication Date
UA102787C2 true UA102787C2 (ru) 2013-08-12

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201207006A UA102787C2 (ru) 2009-12-08 2010-12-08 Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм

Country Status (7)

Country Link
KR (1) KR101144600B1 (ru)
BR (1) BR112012012212A2 (ru)
CO (1) CO6541539A2 (ru)
EA (1) EA019058B1 (ru)
IN (1) IN2012DN03176A (ru)
UA (1) UA102787C2 (ru)
WO (1) WO2011071314A2 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204842B (zh) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 结晶型艾普拉唑钠水合物及其制备方法
CN103204843B (zh) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 结晶型艾普拉唑钠乙醇化物及其制备方法
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746276B (zh) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 一种艾普拉唑钠晶型及其制备方法
CN102746277B (zh) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 一种结晶形式的艾普拉唑钠及其制备方法
CN102746275B (zh) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 结晶型艾普拉唑钠及其制备方法
CN105461692A (zh) * 2014-09-04 2016-04-06 江苏奥赛康药业股份有限公司 艾普拉唑钠化合物及其药物组合物
CN107857756B (zh) * 2017-11-06 2022-08-30 丽珠医药集团股份有限公司 一种艾普拉唑镁晶型及其制备方法
KR102027388B1 (ko) 2017-11-15 2019-10-01 주식회사 다산제약 고순도 일라프라졸 결정형 b의 제조방법
CN111187255B (zh) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 右旋艾普拉唑钾盐的制备方法和右旋艾普拉唑的制备方法
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR102250509B1 (ko) * 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole
CN101687848B (zh) * 2006-12-29 2013-05-15 一洋药品株式会社 外消旋艾普拉唑的固体形式

Also Published As

Publication number Publication date
IN2012DN03176A (ru) 2015-09-25
EA019058B1 (ru) 2013-12-30
WO2011071314A2 (en) 2011-06-16
CO6541539A2 (es) 2012-10-16
BR112012012212A2 (pt) 2015-09-08
EA201200716A1 (ru) 2012-10-30
KR20110064545A (ko) 2011-06-15
KR101144600B1 (ko) 2012-05-16
WO2011071314A3 (en) 2011-11-10

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