UA100125C2 - Способ выделения и очистки монтелукаста - Google Patents
Способ выделения и очистки монтелукастаInfo
- Publication number
- UA100125C2 UA100125C2 UAA201001362A UAA201001362A UA100125C2 UA 100125 C2 UA100125 C2 UA 100125C2 UA A201001362 A UAA201001362 A UA A201001362A UA A201001362 A UAA201001362 A UA A201001362A UA 100125 C2 UA100125 C2 UA 100125C2
- Authority
- UA
- Ukraine
- Prior art keywords
- montelukast
- salts
- isolation
- formula
- primary amines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Abstract
Описывается способ выделения монтелукаста формулы I из реакционных смесей, включающий преобразование неочищенного вещества в соли с первичными аминами, которые хорошо кристаллизуются в среде по крайней мере одного органического растворителя и ацетонитрила, с последующей перекристаллизацией этих солей с последующим удалением химических примесей и применение химически чистых солей монтелукаста с первичными аминами для непосредственной трансформации на фармацевтически пригодную аморфную форму монтелукаста натрия формулы II,, (I)(II).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20070455A CZ302518B6 (cs) | 2007-07-09 | 2007-07-09 | Zpusob izolace a cištení montelukastu |
Publications (1)
Publication Number | Publication Date |
---|---|
UA100125C2 true UA100125C2 (ru) | 2012-11-26 |
Family
ID=40229131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201001362A UA100125C2 (ru) | 2007-07-09 | 2008-07-08 | Способ выделения и очистки монтелукаста |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100267958A1 (ru) |
EP (1) | EP2173718A2 (ru) |
CZ (1) | CZ302518B6 (ru) |
EA (1) | EA018481B1 (ru) |
UA (1) | UA100125C2 (ru) |
WO (1) | WO2009006861A2 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2287154A1 (en) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
WO2012077133A1 (en) * | 2010-12-07 | 2012-06-14 | Ind-Swift Laboratories Limited | Processes for preparation of montelukast sodium and purification of diol intermediate |
CN102060762B (zh) * | 2011-01-28 | 2013-05-29 | 海南美大制药有限公司 | 孟鲁司特化合物及其新制法 |
JP6162004B2 (ja) * | 2013-09-10 | 2017-07-12 | 株式会社トクヤマ | モンテルカストナトリウム中間体の分析方法 |
JP6173864B2 (ja) * | 2013-10-01 | 2017-08-02 | 株式会社トクヤマ | モンテルカストナトリウムのアモルファスを製造する方法 |
CN104119270A (zh) * | 2014-08-12 | 2014-10-29 | 牡丹江恒远药业有限公司 | 一种孟鲁司特钠的制备方法 |
CN105585524B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种由孟鲁司特酸制备孟鲁司特钠的方法 |
CN105924392B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种孟鲁司特钠制备方法 |
CN109503476A (zh) * | 2018-12-26 | 2019-03-22 | 哈尔滨珍宝制药有限公司 | 一种孟鲁司特钠的合成工艺 |
CN112028824B (zh) * | 2020-09-30 | 2021-12-14 | 山东安信制药有限公司 | 一种孟鲁司特钠的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
US5937536A (en) * | 1997-10-06 | 1999-08-17 | Pharmacopeia, Inc. | Rapid drying oven for providing rapid drying of multiple samples |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
CA2528228C (en) * | 2003-06-06 | 2011-09-20 | Morepen Laboratories Limited | A method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
EP1708708A1 (en) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
JP2007532686A (ja) * | 2004-04-21 | 2007-11-15 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカストナトリウムを調製する方法 |
PL205637B1 (pl) * | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
JP2008510840A (ja) * | 2005-07-05 | 2008-04-10 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカストの精製 |
WO2008015703A2 (en) * | 2006-08-04 | 2008-02-07 | Matrix Laboratories Ltd | Process for the preparation of montelukast and its salts thereof |
US8115004B2 (en) * | 2006-11-20 | 2012-02-14 | Msn Laboratories Limited | Process for pure montelukast sodium through pure intermediates as well as amine salts |
-
2007
- 2007-07-09 CZ CZ20070455A patent/CZ302518B6/cs not_active IP Right Cessation
-
2008
- 2008-07-08 WO PCT/CZ2008/000081 patent/WO2009006861A2/en active Application Filing
- 2008-07-08 US US12/667,147 patent/US20100267958A1/en not_active Abandoned
- 2008-07-08 UA UAA201001362A patent/UA100125C2/ru unknown
- 2008-07-08 EA EA201000147A patent/EA018481B1/ru not_active IP Right Cessation
- 2008-07-08 EP EP08784159A patent/EP2173718A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CZ2007455A3 (cs) | 2009-03-04 |
WO2009006861A3 (en) | 2009-05-22 |
US20100267958A1 (en) | 2010-10-21 |
EA201000147A1 (ru) | 2010-06-30 |
EA018481B1 (ru) | 2013-08-30 |
WO2009006861A2 (en) | 2009-01-15 |
EP2173718A2 (en) | 2010-04-14 |
CZ302518B6 (cs) | 2011-06-29 |
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