MX2013000773A - Procedimiento de preparacion de derivados de amino-benzoil-benzofu rano. - Google Patents

Procedimiento de preparacion de derivados de amino-benzoil-benzofu rano.

Info

Publication number
MX2013000773A
MX2013000773A MX2013000773A MX2013000773A MX2013000773A MX 2013000773 A MX2013000773 A MX 2013000773A MX 2013000773 A MX2013000773 A MX 2013000773A MX 2013000773 A MX2013000773 A MX 2013000773A MX 2013000773 A MX2013000773 A MX 2013000773A
Authority
MX
Mexico
Prior art keywords
aminobenzoylbenzofuran
derivatives
preparing
formula
represents hydrogen
Prior art date
Application number
MX2013000773A
Other languages
English (en)
Inventor
Philippe Vayron
Xavier Bon
Corinne Leroy
Christine Biencourt
Julia Mateos-Caro
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2013000773A publication Critical patent/MX2013000773A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un procedimiento de preparación de derivados de 5-amino-benzoil-benzofurano de fórmula general I, en la que R1 representa hidrógeno o un grupo alquilo y R2 representa hidrógeno, un grupo alquilo, alcoxi o dialquilaminoalcoxi: por reducción de un derivado de 5-nitro-benzofurano de fórmula general II: por medio de un agente de transferencia de hidrógeno, en presencia de paladio sobre carbono como catalizador y en un éter o una mezcla de éter como disolvente.
MX2013000773A 2010-07-19 2011-07-18 Procedimiento de preparacion de derivados de amino-benzoil-benzofu rano. MX2013000773A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1055824A FR2962731B1 (fr) 2010-07-19 2010-07-19 Procede de preparation de derives d'amino-benzoyl-benzofurane
PCT/FR2011/051710 WO2012010788A1 (fr) 2010-07-19 2011-07-18 Procede de preparation de derives d'amino-benzoyl-benzofurane

Publications (1)

Publication Number Publication Date
MX2013000773A true MX2013000773A (es) 2013-07-05

Family

ID=42797382

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000773A MX2013000773A (es) 2010-07-19 2011-07-18 Procedimiento de preparacion de derivados de amino-benzoil-benzofu rano.

Country Status (13)

Country Link
US (1) US8884033B2 (es)
EP (1) EP2595976A1 (es)
JP (1) JP2013531054A (es)
KR (1) KR20130129180A (es)
CN (1) CN103108869A (es)
AU (1) AU2011281421A1 (es)
BR (1) BR112013001335A2 (es)
CA (1) CA2805815A1 (es)
FR (1) FR2962731B1 (es)
MX (1) MX2013000773A (es)
RU (1) RU2013107023A (es)
SG (1) SG187140A1 (es)
WO (1) WO2012010788A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
CN102690250A (zh) * 2012-05-08 2012-09-26 郑州明泽医药科技有限公司 决奈达隆中间体及其制备方法
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN104892553B (zh) * 2015-04-27 2017-06-20 惠州信立泰药业有限公司 一种盐酸决奈达隆的晶体及其制备方法和含有该晶体的药物组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
ATE555091T1 (de) * 2006-02-03 2012-05-15 Bionomics Ltd Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
TW201111354A (en) 2009-05-27 2011-04-01 Sanofi Aventis Process for the production of Dronedarone intermediates
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation

Also Published As

Publication number Publication date
CN103108869A (zh) 2013-05-15
FR2962731B1 (fr) 2012-08-17
CA2805815A1 (fr) 2012-01-26
RU2013107023A (ru) 2014-08-27
SG187140A1 (en) 2013-02-28
KR20130129180A (ko) 2013-11-27
WO2012010788A1 (fr) 2012-01-26
US20130165675A1 (en) 2013-06-27
JP2013531054A (ja) 2013-08-01
AU2011281421A1 (en) 2013-02-21
FR2962731A1 (fr) 2012-01-20
US8884033B2 (en) 2014-11-11
EP2595976A1 (fr) 2013-05-29
BR112013001335A2 (pt) 2016-05-17

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