FR2957079B1 - Procede de synthese de derives de cetobenzofurane - Google Patents
Procede de synthese de derives de cetobenzofuraneInfo
- Publication number
- FR2957079B1 FR2957079B1 FR1051510A FR1051510A FR2957079B1 FR 2957079 B1 FR2957079 B1 FR 2957079B1 FR 1051510 A FR1051510 A FR 1051510A FR 1051510 A FR1051510 A FR 1051510A FR 2957079 B1 FR2957079 B1 FR 2957079B1
- Authority
- FR
- France
- Prior art keywords
- cetobenzofuran
- synthesis
- derivatives
- cetobenzofuran derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1051510A FR2957079B1 (fr) | 2010-03-02 | 2010-03-02 | Procede de synthese de derives de cetobenzofurane |
ARP110100607A AR080332A1 (es) | 2010-03-02 | 2011-02-28 | DERIVADOS DE CETOBENZOFURANO, PROCEDIMIENTO PARA SU SíNTESIS E INTERMEDIARIOS DE LA MISMA |
CN2011800219969A CN102884056A (zh) | 2010-03-02 | 2011-03-01 | 酮基苯并呋喃衍生物、其合成方法及中间体 |
JP2012555470A JP2013521264A (ja) | 2010-03-02 | 2011-03-01 | ケトベンゾフラン誘導体、その合成方法および中間体 |
AU2011222828A AU2011222828A1 (en) | 2010-03-02 | 2011-03-01 | Ketobenzofuran derivatives, method for synthesising same, and intermediates |
KR1020127025590A KR20130045249A (ko) | 2010-03-02 | 2011-03-01 | 케토벤조푸란 유도체, 그의 합성 방법, 및 중간체 |
BR112012021865A BR112012021865A2 (pt) | 2010-03-02 | 2011-03-01 | derivados de ceto benzofurano, assim com o respectivo processo de síntese e os intermediários. |
MX2012010121A MX2012010121A (es) | 2010-03-02 | 2011-03-01 | Derivados de cetobenzofurano asi como su procedimiento de sintesis y los intermedios. |
TW100106760A TW201139400A (en) | 2010-03-02 | 2011-03-01 | Process for the synthesis of ketobenzofuran derivatives |
RU2012141889/04A RU2012141889A (ru) | 2010-03-02 | 2011-03-01 | Производные кетобензофурана, способ их синтеза и промежуточные соединения |
SG2012063525A SG183516A1 (en) | 2010-03-02 | 2011-03-01 | Ketobenzofuran derivatives, method for synthesising same, and intermediates |
EP11712941A EP2542544A1 (fr) | 2010-03-02 | 2011-03-01 | Derives de cetobenzofurane ainsi que leur procede de synthese et le intermediaires |
PCT/FR2011/050420 WO2011107705A1 (fr) | 2010-03-02 | 2011-03-01 | Derives de cetobenzofurane ainsi que leur procede de synthese et le intermediaires |
CA2791482A CA2791482A1 (fr) | 2010-03-02 | 2011-03-01 | Derives de cetobenzofurane ainsi que leur procede de synthese et les intermediaires |
UY0001033256A UY33256A (es) | 2010-03-02 | 2011-03-02 | Procedimiento de sintesis de derivados de cetobenzofurano |
US13/599,374 US8796489B2 (en) | 2010-03-02 | 2012-08-30 | Ketobenzofuran derivatives, method for synthesizing same, and intermediates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1051510A FR2957079B1 (fr) | 2010-03-02 | 2010-03-02 | Procede de synthese de derives de cetobenzofurane |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2957079A1 FR2957079A1 (fr) | 2011-09-09 |
FR2957079B1 true FR2957079B1 (fr) | 2012-07-27 |
Family
ID=42935523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1051510A Expired - Fee Related FR2957079B1 (fr) | 2010-03-02 | 2010-03-02 | Procede de synthese de derives de cetobenzofurane |
Country Status (16)
Country | Link |
---|---|
US (1) | US8796489B2 (fr) |
EP (1) | EP2542544A1 (fr) |
JP (1) | JP2013521264A (fr) |
KR (1) | KR20130045249A (fr) |
CN (1) | CN102884056A (fr) |
AR (1) | AR080332A1 (fr) |
AU (1) | AU2011222828A1 (fr) |
BR (1) | BR112012021865A2 (fr) |
CA (1) | CA2791482A1 (fr) |
FR (1) | FR2957079B1 (fr) |
MX (1) | MX2012010121A (fr) |
RU (1) | RU2012141889A (fr) |
SG (1) | SG183516A1 (fr) |
TW (1) | TW201139400A (fr) |
UY (1) | UY33256A (fr) |
WO (1) | WO2011107705A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
FR2958291B1 (fr) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | Procede de preparation de derives d'amino-benzofurane |
HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
FR2962731B1 (fr) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | Procede de preparation de derives d'amino-benzoyl-benzofurane |
FR2963006B1 (fr) * | 2010-07-21 | 2013-03-15 | Sanofi Aventis | Procede de preparation de derives de nitro-benzofurane |
HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
EP2452938A1 (fr) * | 2010-11-12 | 2012-05-16 | LEK Pharmaceuticals d.d. | Procédé pour la préparation de dérivés de 3-aroyl-5-aminobenzofurane |
HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
EP2617718A1 (fr) | 2012-01-20 | 2013-07-24 | Sanofi | Procédé de préparation de dronédarone à l'aide d'un réactif dibutylaminopropanol |
US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
US9249119B2 (en) | 2012-02-14 | 2016-02-02 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
WO2013124745A1 (fr) | 2012-02-22 | 2013-08-29 | Sanofi | Procédé pour la préparation de dronédarone par l'oxydation d'un groupe hydroxyle |
US9238636B2 (en) | 2012-05-31 | 2016-01-19 | Sanofi | Process for preparation of dronedarone by Grignard reaction |
TW201536763A (zh) * | 2013-08-27 | 2015-10-01 | Gilead Sciences Inc | 製備決奈達隆或其鹽類之製程 |
CN109384754B (zh) * | 2017-08-14 | 2020-06-09 | 新发药业有限公司 | 一种盐酸决奈达隆的制备方法 |
CN107827764A (zh) * | 2017-11-27 | 2018-03-23 | 上海应用技术大学 | 一种双β‑氨基酮或双β‑氨基酯类的制备方法 |
BR112022000174A2 (pt) * | 2019-07-08 | 2022-04-12 | Nat Univ Singapore | Terapêutica cardíaca |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE45765B1 (en) * | 1976-08-19 | 1982-11-17 | Ici Ltd | Triazoles and imidazoles useful as plant fungicides and growth regulating agents |
US5066803A (en) * | 1989-12-07 | 1991-11-19 | Sterling Drug Inc. | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines |
FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
FR2817864B1 (fr) | 2000-12-11 | 2003-02-21 | Sanofi Synthelabo | Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese |
FR2817865B1 (fr) | 2000-12-11 | 2005-02-18 | Sanofi Synthelabo | Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese |
IL146389A0 (en) * | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
EP1741702A1 (fr) * | 2004-04-28 | 2007-01-10 | Ono Pharmaceutical Co., Ltd. | Composés hétérocycliques contenant de l'azote et utilisation médicinale de ceux-ci |
CA2644578A1 (fr) * | 2006-03-03 | 2007-09-07 | Torrent Pharmaceuticals Ltd | Nouveaux antagonistes a double action de recepteurs (dara) des recepteurs ati et eta |
GB0719180D0 (en) * | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
TW201111354A (en) | 2009-05-27 | 2011-04-01 | Sanofi Aventis | Process for the production of Dronedarone intermediates |
TW201107303A (en) | 2009-05-27 | 2011-03-01 | Sanofi Aventis | Process for the production of benzofurans |
HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
FR2958291B1 (fr) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | Procede de preparation de derives d'amino-benzofurane |
FR2973027A1 (fr) | 2011-03-24 | 2012-09-28 | Sanofi Aventis | Procede de synthese de derives de cetobenzofurane |
HUP1100166A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Reductive amination process for preparation of dronedarone using amine intermediary compound |
HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
WO2013014479A1 (fr) | 2011-07-26 | 2013-01-31 | Sanofi | Procédé d'amination réductrice pour la préparation de dronédarone, utilisant un composé intermédiaire aldéhyde |
WO2013014480A1 (fr) | 2011-07-26 | 2013-01-31 | Sanofi | Procédé de préparation de dronédarone utilisant un composé intermédiaire amide |
WO2013014478A1 (fr) | 2011-07-26 | 2013-01-31 | Sanofi | Procédé d'amination réductrice pour la préparation de dronédarone, utilisant un composé intermédiaire carboxyle |
-
2010
- 2010-03-02 FR FR1051510A patent/FR2957079B1/fr not_active Expired - Fee Related
-
2011
- 2011-02-28 AR ARP110100607A patent/AR080332A1/es not_active Application Discontinuation
- 2011-03-01 BR BR112012021865A patent/BR112012021865A2/pt not_active IP Right Cessation
- 2011-03-01 AU AU2011222828A patent/AU2011222828A1/en not_active Abandoned
- 2011-03-01 TW TW100106760A patent/TW201139400A/zh unknown
- 2011-03-01 EP EP11712941A patent/EP2542544A1/fr not_active Withdrawn
- 2011-03-01 RU RU2012141889/04A patent/RU2012141889A/ru not_active Application Discontinuation
- 2011-03-01 KR KR1020127025590A patent/KR20130045249A/ko not_active Application Discontinuation
- 2011-03-01 WO PCT/FR2011/050420 patent/WO2011107705A1/fr active Application Filing
- 2011-03-01 CA CA2791482A patent/CA2791482A1/fr not_active Abandoned
- 2011-03-01 MX MX2012010121A patent/MX2012010121A/es not_active Application Discontinuation
- 2011-03-01 JP JP2012555470A patent/JP2013521264A/ja active Pending
- 2011-03-01 SG SG2012063525A patent/SG183516A1/en unknown
- 2011-03-01 CN CN2011800219969A patent/CN102884056A/zh active Pending
- 2011-03-02 UY UY0001033256A patent/UY33256A/es not_active Application Discontinuation
-
2012
- 2012-08-30 US US13/599,374 patent/US8796489B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2791482A1 (fr) | 2011-09-09 |
US8796489B2 (en) | 2014-08-05 |
SG183516A1 (en) | 2012-10-30 |
RU2012141889A (ru) | 2014-04-10 |
UY33256A (es) | 2011-09-30 |
TW201139400A (en) | 2011-11-16 |
KR20130045249A (ko) | 2013-05-03 |
JP2013521264A (ja) | 2013-06-10 |
AR080332A1 (es) | 2012-03-28 |
MX2012010121A (es) | 2012-09-12 |
AU2011222828A1 (en) | 2012-09-20 |
EP2542544A1 (fr) | 2013-01-09 |
BR112012021865A2 (pt) | 2016-05-17 |
US20130012729A1 (en) | 2013-01-10 |
WO2011107705A1 (fr) | 2011-09-09 |
FR2957079A1 (fr) | 2011-09-09 |
CN102884056A (zh) | 2013-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20151130 |