PE20131097A1 - Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable - Google Patents

Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable

Info

Publication number
PE20131097A1
PE20131097A1 PE2012002077A PE2012002077A PE20131097A1 PE 20131097 A1 PE20131097 A1 PE 20131097A1 PE 2012002077 A PE2012002077 A PE 2012002077A PE 2012002077 A PE2012002077 A PE 2012002077A PE 20131097 A1 PE20131097 A1 PE 20131097A1
Authority
PE
Peru
Prior art keywords
ivabradine
synthesis
salts
pharmaceutically acceptable
addition
Prior art date
Application number
PE2012002077A
Other languages
English (en)
Inventor
Jean-Luc Renaud
Jean-Pierre Lecouve
Solenne Moulin
Nicolas Pannetier
Lucile Vaysse-Ludot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47115640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131097(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of PE20131097A1 publication Critical patent/PE20131097A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UN PROCEDIMIENTO DE SINTESIS DE LA IVABRADINA DE FORMULA (I), DONDE UN COMPUESTO DE FORMULA (V) SE SOMETE A UNA REACCION DE AMINACION REDUCTORA POR LA AMINA DE FORMULA (VI) EN PRESENCIA DE UN CATALIZADOR A BASE DE HIERRO, N-OXIDO DE TRIMETILAMINA, BAJO UNA PRESION DE DIHIDROGENO DE ENTRE 1 BAR Y 20 BAR, EN UN DISOLVENTE ORGANICO TAL COMO ETANOL Y A UNA TEMPERATURA DE ENTRE 25 °C Y 100 °C
PE2012002077A 2011-12-20 2012-10-25 Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable PE20131097A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103933A FR2984319B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
PE20131097A1 true PE20131097A1 (es) 2013-10-12

Family

ID=47115640

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002077A PE20131097A1 (es) 2011-12-20 2012-10-25 Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable

Country Status (35)

Country Link
US (1) US8513410B2 (es)
EP (1) EP2607353B1 (es)
JP (1) JP5670406B2 (es)
KR (1) KR101470879B1 (es)
CN (1) CN103172566B (es)
AR (1) AR088678A1 (es)
AU (1) AU2012244188B2 (es)
BR (1) BR102012028614A2 (es)
CA (1) CA2795741C (es)
CL (1) CL2012003136A1 (es)
CY (1) CY1115682T1 (es)
DK (1) DK2607353T3 (es)
EA (1) EA026510B1 (es)
ES (1) ES2525032T3 (es)
FR (1) FR2984319B1 (es)
GE (1) GEP20156350B (es)
HK (1) HK1186733A1 (es)
HR (1) HRP20141023T1 (es)
JO (1) JO3031B1 (es)
MA (1) MA34276B1 (es)
MD (1) MD4336C1 (es)
MX (1) MX2012012938A (es)
MY (1) MY170662A (es)
PE (1) PE20131097A1 (es)
PL (1) PL2607353T3 (es)
PT (1) PT2607353E (es)
RS (1) RS53541B1 (es)
SA (1) SA112330994B1 (es)
SG (1) SG191471A1 (es)
SI (1) SI2607353T1 (es)
TW (1) TWI440627B (es)
UA (1) UA111329C2 (es)
UY (1) UY34423A (es)
WO (1) WO2013093220A1 (es)
ZA (1) ZA201208160B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN105669554A (zh) * 2016-02-22 2016-06-15 徐建立 一种盐酸伊伐布雷定杂质及其制备方法和应用
FR3071833B1 (fr) * 2017-09-29 2020-01-03 Universite Paris-Sud Nouveau procede de synthese d'amines tertiaires dissymetriques

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US6225487B1 (en) * 1998-04-17 2001-05-01 Symyx Technologies, Inc. Ancillary ligands and metal complexes, catalysts and compositions using same and methods of testing
US6521793B1 (en) * 1998-10-08 2003-02-18 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP1595888A1 (en) * 2004-05-11 2005-11-16 Degussa AG Cycloolefin phosphine ligands and their use in catalysis
EP2097383B1 (en) * 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
US8212026B2 (en) * 2007-05-30 2012-07-03 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof
US7857994B2 (en) 2007-05-30 2010-12-28 GE Lighting Solutions, LLC Green emitting phosphors and blends thereof
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2940287B1 (fr) 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
AR088678A1 (es) 2014-06-25
CA2795741C (fr) 2015-09-08
MY170662A (en) 2019-08-26
MA34276B1 (fr) 2013-06-01
MX2012012938A (es) 2013-06-19
FR2984319B1 (fr) 2013-12-27
HK1186733A1 (zh) 2014-03-21
AU2012244188A1 (en) 2013-07-04
US20130158256A1 (en) 2013-06-20
US8513410B2 (en) 2013-08-20
CY1115682T1 (el) 2017-01-25
TW201326132A (zh) 2013-07-01
HRP20141023T1 (hr) 2014-12-05
ZA201208160B (en) 2013-06-26
NZ603483A (en) 2014-02-28
TWI440627B (zh) 2014-06-11
KR101470879B1 (ko) 2014-12-09
KR20130071350A (ko) 2013-06-28
EP2607353B1 (fr) 2014-08-27
EA026510B1 (ru) 2017-04-28
CA2795741A1 (fr) 2013-06-20
CN103172566A (zh) 2013-06-26
WO2013093220A1 (fr) 2013-06-27
EP2607353A1 (fr) 2013-06-26
GEP20156350B (en) 2015-08-25
PL2607353T3 (pl) 2015-01-30
CN103172566B (zh) 2015-11-18
JP5670406B2 (ja) 2015-02-18
ES2525032T3 (es) 2014-12-16
CL2012003136A1 (es) 2014-08-01
FR2984319A1 (fr) 2013-06-21
RS53541B1 (en) 2015-02-27
DK2607353T3 (en) 2014-12-08
AU2012244188B2 (en) 2015-07-30
UA111329C2 (uk) 2016-04-25
JP2013129650A (ja) 2013-07-04
SG191471A1 (en) 2013-07-31
SI2607353T1 (sl) 2014-12-31
MD4336C1 (ro) 2015-10-31
BR102012028614A2 (pt) 2014-12-16
EA201201385A1 (ru) 2013-06-28
MD4336B1 (ro) 2015-03-31
PT2607353E (pt) 2014-10-10
SA112330994B1 (ar) 2015-08-03
JO3031B1 (ar) 2016-09-05
UY34423A (es) 2013-07-31

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