WO2010030132A3 - 아데포비어 디피복실의 정제방법 - Google Patents

아데포비어 디피복실의 정제방법 Download PDF

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Publication number
WO2010030132A3
WO2010030132A3 PCT/KR2009/005150 KR2009005150W WO2010030132A3 WO 2010030132 A3 WO2010030132 A3 WO 2010030132A3 KR 2009005150 W KR2009005150 W KR 2009005150W WO 2010030132 A3 WO2010030132 A3 WO 2010030132A3
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WO
WIPO (PCT)
Prior art keywords
adefovir dipivoxil
purified
chemical formula
solution
present
Prior art date
Application number
PCT/KR2009/005150
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English (en)
French (fr)
Other versions
WO2010030132A9 (ko
WO2010030132A2 (ko
Inventor
조일환
윤명식
최광도
이용택
이시범
방성철
이민경
오다원
Original Assignee
씨제이제일제당 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 씨제이제일제당 주식회사 filed Critical 씨제이제일제당 주식회사
Priority to JP2011526814A priority Critical patent/JP5390617B2/ja
Priority to EP09813254A priority patent/EP2327708A4/en
Priority to CN200980134900.2A priority patent/CN102143967B/zh
Priority to US13/063,449 priority patent/US20110207928A1/en
Publication of WO2010030132A2 publication Critical patent/WO2010030132A2/ko
Publication of WO2010030132A3 publication Critical patent/WO2010030132A3/ko
Publication of WO2010030132A9 publication Critical patent/WO2010030132A9/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

본 발명은 화학식 1의 아데포비어 디피복실의 새로운 정제 방법에 관한 것으로, 본 발명에 따른 정제 방법은, 합성을 통하여 제조된 부산물이 포함된 불순한 상태의 아데포비어 디피복실, 이의 염 또는 이의 복합체를, 물 또는 물을 포함한 혼합용매에 용해시키는 단계, 아데포비어 디피복실 용액을 역상컬럼으로 통해 정제하는 단계 및 정제된 아데포비어 디피복실 용액에 염기를 첨가하고 유기용매로 추출하는 단계를 이용하여 화학식 1로 표시되는 고순도의 아데포비어 디피복실을 정제하는 방법을 포함한다. 또한 본 발명은 상기 방법을 사용하여 정제된 화학식 1로 표시되는 고순도의 아데포비어 디피복실 용액에서 용매를 제거하여 무정형의 아데포비어 디피복실을 제조하는 방법을 포함한다.
PCT/KR2009/005150 2008-09-11 2009-09-10 아데포비어 디피복실의 정제방법 WO2010030132A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2011526814A JP5390617B2 (ja) 2008-09-11 2009-09-10 アデホビルジピボキシルの精製方法
EP09813254A EP2327708A4 (en) 2008-09-11 2009-09-10 PROCESS FOR PURIFYING ADEFOVIR DIPIVOXIL
CN200980134900.2A CN102143967B (zh) 2008-09-11 2009-09-10 阿德福韦酯的纯化方法
US13/063,449 US20110207928A1 (en) 2008-09-11 2009-09-10 Purification method for adefovir dipivoxil

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20080089907 2008-09-11
KR10-2008-0089907 2008-09-11
KR1020090001395A KR20100031045A (ko) 2008-09-11 2009-01-08 아데포비어 디피복실의 정제방법
KR10-2009-0001395 2009-01-08

Publications (3)

Publication Number Publication Date
WO2010030132A2 WO2010030132A2 (ko) 2010-03-18
WO2010030132A3 true WO2010030132A3 (ko) 2010-06-10
WO2010030132A9 WO2010030132A9 (ko) 2010-08-05

Family

ID=42180843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005150 WO2010030132A2 (ko) 2008-09-11 2009-09-10 아데포비어 디피복실의 정제방법

Country Status (7)

Country Link
US (1) US20110207928A1 (ko)
EP (1) EP2327708A4 (ko)
JP (2) JP5390617B2 (ko)
KR (2) KR20100031045A (ko)
CN (1) CN102143967B (ko)
TW (1) TWI372761B (ko)
WO (1) WO2010030132A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR101247653B1 (ko) * 2010-11-08 2013-04-01 (주) 성운파마코피아 아데포비어 디피복실 제조방법
US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
CN103880884A (zh) * 2014-03-21 2014-06-25 浙江苏泊尔制药有限公司 一种高纯度富马酸泰诺福韦酯的制备方法
TWI609745B (zh) * 2015-07-02 2018-01-01 嘉新精密有限公司 側向夾持的彈性定位塊結構
CN105294762A (zh) * 2015-11-13 2016-02-03 中国药科大学 阿德福韦酯杂质的制备方法
CN106167503B (zh) * 2016-07-07 2018-06-22 福建广生堂药业股份有限公司 一种阿德福韦酯羟甲基杂质的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates

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PT1256584E (pt) 1997-07-25 2004-12-31 Gilead Sciences Inc Processo para a preparacao de adefovir-dipivoxil
ZA986614B (en) * 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
TWI230618B (en) 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
CN1935818B (zh) * 2006-09-22 2011-11-09 闫敬武 阿德福韦酯新晶态、晶态组合物、制备方法及应用
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
WO2010032958A2 (ko) * 2008-09-17 2010-03-25 씨제이제일제당 (주) 아데포비어 디피복실의 안정화된 고체 분산체 및 이의 제조 방법
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUI-CHANG BI ET AL: "Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to pharmacokinetic study", RAPID COMMUNACATIONS IN MASS SEPCTROMETRY, vol. 19, no. 20, 2005, pages 2911 - 2917, XP002658318 *

Also Published As

Publication number Publication date
EP2327708A2 (en) 2011-06-01
TW201016713A (en) 2010-05-01
JP2014114271A (ja) 2014-06-26
WO2010030132A9 (ko) 2010-08-05
KR100970434B1 (ko) 2010-07-15
TWI372761B (en) 2012-09-21
CN102143967B (zh) 2015-02-04
EP2327708A4 (en) 2011-11-30
JP5390617B2 (ja) 2014-01-15
US20110207928A1 (en) 2011-08-25
KR20100031045A (ko) 2010-03-19
WO2010030132A2 (ko) 2010-03-18
JP2012512137A (ja) 2012-05-31
CN102143967A (zh) 2011-08-03
KR20100031085A (ko) 2010-03-19

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