WO2008090819A1 - 二環性プロリン化合物の製造方法 - Google Patents
二環性プロリン化合物の製造方法 Download PDFInfo
- Publication number
- WO2008090819A1 WO2008090819A1 PCT/JP2008/050607 JP2008050607W WO2008090819A1 WO 2008090819 A1 WO2008090819 A1 WO 2008090819A1 JP 2008050607 W JP2008050607 W JP 2008050607W WO 2008090819 A1 WO2008090819 A1 WO 2008090819A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compound represented
- compound
- hydrogen atom
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
工業的製造に適した光学活性3-アザビシクロ[3.3.0]オクタン-2-カルボン酸に代表される二環性プロリン化合物の製造方法の提供。 式(1)で表される化合物を、塩基存在下、式(2)で表されるシクロペンテン-1-カルボアルデヒドと反応させ、式(3)で表される化合物を得る。式(3)で表される化合物を酸で処理し、式(4)で表される化合物を得る。式(4)で表される化合物を得た後、さらに還元反応を行う工程、及びアミノ基を保護基で保護するか又は保護しない工程を経て、式(5)で表される二環性プロリン化合物又はその塩に誘導する。 [式中、Xは水素原子又は塩素原子を示し、*1、*2、*3及び*4は不斉炭素原子であることを示し、不斉炭素原子の立体配置はS又はRである。*1、*2、*3及び*4の不斉炭素原子の立体配置はそれぞれS,S,S,R又はR,R,R,Sである。R1及びR2は、それぞれ独立に水素原子又はカルボキシル基の保護基を示す。Pは水素原子又はアミノ基の保護基を示す。]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007012361A JP2010090031A (ja) | 2007-01-23 | 2007-01-23 | 二環性プロリン化合物の製造方法 |
JP2007-012361 | 2007-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008090819A1 true WO2008090819A1 (ja) | 2008-07-31 |
Family
ID=39644396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/050607 WO2008090819A1 (ja) | 2007-01-23 | 2008-01-18 | 二環性プロリン化合物の製造方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2010090031A (ja) |
WO (1) | WO2008090819A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014033667A1 (en) | 2012-08-30 | 2014-03-06 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir |
WO2014096374A1 (en) | 2012-12-21 | 2014-06-26 | Sandoz Ag | Process for the synthesis of pyrrolidines and pyrroles |
WO2014203224A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and its intermediates |
WO2014203208A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and intermediates thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5829529B2 (ja) * | 2011-08-29 | 2015-12-09 | 日本曹達株式会社 | 光学活性4級アンモニウム塩、および光学活性化合物の製造方法 |
-
2007
- 2007-01-23 JP JP2007012361A patent/JP2010090031A/ja active Pending
-
2008
- 2008-01-18 WO PCT/JP2008/050607 patent/WO2008090819A1/ja active Application Filing
Non-Patent Citations (2)
Title |
---|
BERGMEIER S.C. ET AL.: "Synthesis of bicyclic proline analogs using a formal [3 + 2] intramolecular aziridine-allylsilane cycloaddition reaction", TETRAHEDRON, vol. 55, no. 26, 1999, pages 8025 - 8038, XP004168571, DOI: doi:10.1016/S0040-4020(99)00425-1 * |
MONN J.A. ET AL.: "A Concise, Stereocontrolled Thiazolium Ylide Approach to Kainic Acid", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 10, 1994, pages 2773 - 2778, XP002419726, DOI: doi:10.1021/jo00089a022 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014033667A1 (en) | 2012-08-30 | 2014-03-06 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir |
WO2014096374A1 (en) | 2012-12-21 | 2014-06-26 | Sandoz Ag | Process for the synthesis of pyrrolidines and pyrroles |
WO2014203224A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and its intermediates |
WO2014203208A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and intermediates thereof |
Also Published As
Publication number | Publication date |
---|---|
JP2010090031A (ja) | 2010-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1806408A4 (en) | PROCESS FOR SYNTHESIZING AN AMINO ACID DERIVATIVE FROM A HYDROXYIMINOACID | |
EP2412700A4 (en) | PROCESS FOR PREPARING A BICYCLIC GAMMA AMINO ACID DERIVATIVE | |
SG170729A1 (en) | Processes and intermediates for preparing steric compounds | |
TW200633989A (en) | Method for producing (4,5-dihydroisoxazolo-3-yl)thioformamidine chloride | |
WO2008090819A1 (ja) | 二環性プロリン化合物の製造方法 | |
WO2008078589A1 (ja) | 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 | |
EP1880987A4 (en) | PROCESS FOR PREPARING A CYCLOPROPYLPHENOL DERIVATIVE | |
PT1656381E (pt) | Cristalização de formas sólidas de sais de adição de clopidogrel | |
IL186014A (en) | Process for the preparation of 2-azabicyclo[3.3.0] octane-3-carboxylic acid derivatives | |
WO2008102669A1 (ja) | 新規な糖連結クロリン誘導体及びその製造方法 | |
EP1460065A4 (en) | METHOD FOR THE PRODUCTION OF CYCLIC DIAMINO COMPOUNDS BZW. THE SALTS | |
MXPA03011516A (es) | Procedimiento de sintesis tecnico para la preparacion de tropenol. | |
MX2007006747A (es) | Procedimiento para la preparacion de anilinas. | |
ATE486867T1 (de) | Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz | |
HK1139135A1 (en) | Process for the preparation of pleuromutilins | |
IL164978A0 (en) | A process for the preparation of clopidogrel | |
SG195161A1 (en) | Method for producing proline compound | |
TW200624422A (en) | Process for production of 2-chloro-4-nitroimidazole | |
WO2014133291A9 (ko) | (2rs)-아미노-(3s)-히드록시-부티르산 또는 이의 유도체의 제조방법 | |
MY161959A (en) | Continuous production of high purity carbon dioxide | |
EP1342715A3 (en) | Process for producing oximes using nitirites | |
WO2009028563A1 (ja) | シス-3-置換-3-アザビシクロ[3.2.1]オクタン-8-オール誘導体の製造方法 | |
EP1518856A4 (en) | PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE | |
TW200724527A (en) | Process for the production of hydroxyalkylmaleimides | |
MY141734A (en) | Methods for producing quinazoline alkaloids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08703457 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 08703457 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: JP |