WO2008078589A1 - 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 - Google Patents

放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 Download PDF

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Publication number
WO2008078589A1
WO2008078589A1 PCT/JP2007/074220 JP2007074220W WO2008078589A1 WO 2008078589 A1 WO2008078589 A1 WO 2008078589A1 JP 2007074220 W JP2007074220 W JP 2007074220W WO 2008078589 A1 WO2008078589 A1 WO 2008078589A1
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Prior art keywords
compound
base
leaving group
syn
carbon atoms
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PCT/JP2007/074220
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English (en)
French (fr)
Inventor
Masahito Toyama
Akio Hayashi
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Nihon Medi-Physics Co., Ltd.
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Publication date
Priority to EP07850708.4A priority Critical patent/EP2128130B1/en
Application filed by Nihon Medi-Physics Co., Ltd. filed Critical Nihon Medi-Physics Co., Ltd.
Priority to BRPI0720465A priority patent/BRPI0720465B8/pt
Priority to CA2672914A priority patent/CA2672914C/en
Priority to KR1020097010950A priority patent/KR101408727B1/ko
Priority to CN200780048213.XA priority patent/CN101573330B/zh
Priority to NO20181508A priority patent/NO345488B1/no
Priority to US12/448,311 priority patent/US8563771B2/en
Priority to AU2007337481A priority patent/AU2007337481B2/en
Priority to EP18198896.5A priority patent/EP3530648B1/en
Priority to JP2008551038A priority patent/JP5518337B2/ja
Publication of WO2008078589A1 publication Critical patent/WO2008078589A1/ja
Priority to NO20092389A priority patent/NO343437B1/no
Priority to HK09112138.9A priority patent/HK1135372A1/xx

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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)

Abstract

【課題】放射性フッ素標識アミノ酸標識化合物の製造に有用な標識前駆体の製造方法を提供すること。 【解決手段】ＦＡＣＢＣのｓｙｎ－ＯＨ体とａｎｔｉ－ＯＨ体との混合物に脱離基を導入する反応工程において、反応系に塩基を存在させることにより、塩基に対して反応性を示さず安定性の高いｓｙｎ脱離基付加体と、塩基と反応して水溶性化合物となるａｎｔｉ脱離基付加体とが生成する。この溶解度差を利用した精製方法により、ｓｙｎ脱離基付加体を選択的に分離できるようになる。塩基としては、直鎖又は分岐鎖の炭素数１から１０の一級から三級のアルキルアミン、炭素数２から２０の窒素含有複素環化合物、および炭素数２から２０の窒素含有ヘテロ芳香族環化合物が用いられる。
PCT/JP2007/074220 2006-12-27 2007-12-17 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 WO2008078589A1 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
NO20181508A NO345488B1 (no) 2006-12-27 2007-12-17 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse
BRPI0720465A BRPI0720465B8 (pt) 2006-12-27 2007-12-17 processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo
CA2672914A CA2672914C (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound
KR1020097010950A KR101408727B1 (ko) 2006-12-27 2007-12-17 방사성 할로겐 표식 유기 화합물의 전구체 화합물의 제조 방법
CN200780048213.XA CN101573330B (zh) 2006-12-27 2007-12-17 放射性卤素标记的有机化合物的前体化合物的制备方法
EP07850708.4A EP2128130B1 (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound
US12/448,311 US8563771B2 (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound
JP2008551038A JP5518337B2 (ja) 2006-12-27 2007-12-17 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
EP18198896.5A EP3530648B1 (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound
AU2007337481A AU2007337481B2 (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound
NO20092389A NO343437B1 (no) 2006-12-27 2009-06-23 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse
HK09112138.9A HK1135372A1 (en) 2006-12-27 2009-12-24 Process for production of precursor compound for radioactive halogen- labeled organic compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-351883 2006-12-27
JP2006351883 2006-12-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18198896.5A Previously-Filed-Application EP3530648B1 (en) 2006-12-27 2007-12-17 Process for production of precursor compound for radioactive halogen-labeled organic compound

Publications (1)

Publication Number Publication Date
WO2008078589A1 true WO2008078589A1 (ja) 2008-07-03

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ID=39562382

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Application Number Title Priority Date Filing Date
PCT/JP2007/074220 WO2008078589A1 (ja) 2006-12-27 2007-12-17 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法

Country Status (13)

Country Link
US (1) US8563771B2 (ja)
EP (2) EP2128130B1 (ja)
JP (1) JP5518337B2 (ja)
KR (1) KR101408727B1 (ja)
CN (1) CN101573330B (ja)
AU (1) AU2007337481B2 (ja)
BR (1) BRPI0720465B8 (ja)
CA (1) CA2672914C (ja)
HK (1) HK1135372A1 (ja)
NO (2) NO345488B1 (ja)
RU (1) RU2466984C2 (ja)
TW (1) TWI402079B (ja)
WO (1) WO2008078589A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011526932A (ja) * 2008-07-07 2011-10-20 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 放射性医薬品の製造のための方法
JP2014506236A (ja) * 2010-11-29 2014-03-13 ジーイー・ヘルスケア・リミテッド Ｐｅｔ前駆体の製造
JP2014509303A (ja) * 2010-12-20 2014-04-17 ジーイー・ヘルスケア・リミテッド 結晶化による前駆体化合物の精製
JP2015530985A (ja) * 2012-08-09 2015-10-29 ジーイー・ヘルスケア・リミテッド １８ｆ−フルシクロビンの製造
JP2017214389A (ja) * 2010-12-20 2017-12-07 ジーイー・ヘルスケア・リミテッド 結晶化による前駆体化合物の精製

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101608755B1 (ko) 2005-11-29 2016-04-04 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
BR112013020627B1 (pt) * 2011-03-08 2019-12-03 Ge Healthcare Ltd processo para preparação de um composto
CA3055417A1 (en) * 2017-03-07 2018-09-13 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeling precursor compound and method for producing radioactive fluorine-labeled compound using same

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WO2006126410A1 (ja) * 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
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WO2007132689A1 (ja) * 2006-05-11 2007-11-22 Nihon Medi-Physics Co., Ltd. 放射性フッ素標識有機化合物の製造方法

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GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
JP2004056725A (ja) * 2002-07-24 2004-02-19 Matsushita Electric Works Ltd 設備管理サーバ、設備監視制御システムおよび設備管理サーバ用プログラム
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WO1997017092A1 (en) 1995-11-09 1997-05-15 Emory University Amino acid analogs for tumor imaging
JP2000500442A (ja) * 1995-11-09 2000-01-18 エモリー ユニバーシティ 腫瘍画像化のためのアミノ酸アナログ
WO2004056725A1 (en) 2002-12-20 2004-07-08 Ge Healthcare Limited Solid-phase preparation of 18f-labelled amino acids
JP2006510706A (ja) * 2002-12-20 2006-03-30 ジーイー・ヘルスケア・リミテッド １８ｆ−標識アミノ酸の固相製造
WO2006126410A1 (ja) * 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
WO2007063824A1 (ja) * 2005-11-29 2007-06-07 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物
WO2007132689A1 (ja) * 2006-05-11 2007-11-22 Nihon Medi-Physics Co., Ltd. 放射性フッ素標識有機化合物の製造方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011526932A (ja) * 2008-07-07 2011-10-20 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 放射性医薬品の製造のための方法
JP2014506236A (ja) * 2010-11-29 2014-03-13 ジーイー・ヘルスケア・リミテッド Ｐｅｔ前駆体の製造
JP2014509303A (ja) * 2010-12-20 2014-04-17 ジーイー・ヘルスケア・リミテッド 結晶化による前駆体化合物の精製
JP2017214389A (ja) * 2010-12-20 2017-12-07 ジーイー・ヘルスケア・リミテッド 結晶化による前駆体化合物の精製
JP2015530985A (ja) * 2012-08-09 2015-10-29 ジーイー・ヘルスケア・リミテッド １８ｆ−フルシクロビンの製造
US10023525B2 (en) 2012-08-09 2018-07-17 Ge Healthcare Limited Preparation of 18F-fluciclovine

Also Published As

Publication number Publication date
TW200826965A (en) 2008-07-01
US8563771B2 (en) 2013-10-22
JPWO2008078589A1 (ja) 2010-04-22
NO343437B1 (no) 2019-03-11
CA2672914C (en) 2014-02-04
EP2128130B1 (en) 2018-10-10
EP3530648B1 (en) 2023-11-08
NO345488B1 (no) 2021-03-01
TWI402079B (zh) 2013-07-21
AU2007337481B2 (en) 2012-02-09
EP2128130A1 (en) 2009-12-02
US20100016626A1 (en) 2010-01-21
KR20090093969A (ko) 2009-09-02
CN101573330B (zh) 2015-04-08
RU2009128664A (ru) 2011-02-10
NO20092389L (no) 2009-09-21
KR101408727B1 (ko) 2014-06-17
BRPI0720465B1 (pt) 2018-11-27
RU2466984C2 (ru) 2012-11-20
JP5518337B2 (ja) 2014-06-11
CN101573330A (zh) 2009-11-04
CA2672914A1 (en) 2008-07-03
NO20181508A1 (no) 2009-09-21
AU2007337481A1 (en) 2008-07-03
HK1135372A1 (en) 2010-06-04
EP3530648A1 (en) 2019-08-28
BRPI0720465A2 (pt) 2014-01-14
EP2128130A4 (en) 2012-01-04
BRPI0720465B8 (pt) 2021-07-27

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