BRPI0720465B8 - processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo - Google Patents

processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo

Info

Publication number
BRPI0720465B8
BRPI0720465B8 BRPI0720465A BRPI0720465A BRPI0720465B8 BR PI0720465 B8 BRPI0720465 B8 BR PI0720465B8 BR PI0720465 A BRPI0720465 A BR PI0720465A BR PI0720465 A BRPI0720465 A BR PI0720465A BR PI0720465 B8 BRPI0720465 B8 BR PI0720465B8
Authority
BR
Brazil
Prior art keywords
compound
base
leaving group
producing
adduct
Prior art date
Application number
BRPI0720465A
Other languages
English (en)
Inventor
Hayashi Akio
Toyama Masahito
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of BRPI0720465A2 publication Critical patent/BRPI0720465A2/pt
Publication of BRPI0720465B1 publication Critical patent/BRPI0720465B1/pt
Publication of BRPI0720465B8 publication Critical patent/BRPI0720465B8/pt

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)

Abstract

processo para produção de composto precursor para composto orgânico marcado com halogênio radioativo. trata-se de um processo para produzir um precursor marcado que é útil para a produção de um composto aminoácido marcado com flúor radioativo. na etapa de reação para introduzir um grupo abandonador em uma mistura da forma sin e da forma anti do facbc, deixa-se uma base estar presente no sistema de reação para produzir um aduto do grupo abandonador sin que não reage com a base e é altamente estável, e um aduto do grupo abandonador anti capaz de reagir com a base para formar um composto hidrossolúvel. ao empregar um método de purificação que utiliza tal diferença na solubilidade, o aduto do grupo abandonador sin pode ser separado seletivamente. a base pode ser uma alquila-mina primária a terciária, de cadeia linear ou cadeia ramificada, com 1 a 10 átomos de carbono, um composto heterocíclico contendo nitrogênio com 2 a 20 átomos de carbono, e um composto heteroaromático contendo nitrogênio com 2 a 20 átomos de carbono.
BRPI0720465A 2006-12-27 2007-12-17 processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo BRPI0720465B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-351883 2006-12-27
JP2006351883 2006-12-27
PCT/JP2007/074220 WO2008078589A1 (ja) 2006-12-27 2007-12-17 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法

Publications (3)

Publication Number Publication Date
BRPI0720465A2 BRPI0720465A2 (pt) 2014-01-14
BRPI0720465B1 BRPI0720465B1 (pt) 2018-11-27
BRPI0720465B8 true BRPI0720465B8 (pt) 2021-07-27

Family

ID=39562382

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720465A BRPI0720465B8 (pt) 2006-12-27 2007-12-17 processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo

Country Status (13)

Country Link
US (1) US8563771B2 (pt)
EP (2) EP2128130B1 (pt)
JP (1) JP5518337B2 (pt)
KR (1) KR101408727B1 (pt)
CN (1) CN101573330B (pt)
AU (1) AU2007337481B2 (pt)
BR (1) BRPI0720465B8 (pt)
CA (1) CA2672914C (pt)
HK (1) HK1135372A1 (pt)
NO (2) NO345488B1 (pt)
RU (1) RU2466984C2 (pt)
TW (1) TWI402079B (pt)
WO (1) WO2008078589A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101608755B1 (ko) 2005-11-29 2016-04-04 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물
EP2318332A1 (en) * 2008-07-07 2011-05-11 Bayer Schering Pharma Aktiengesellschaft Process for production of radiopharmaceuticals
AU2011335084B2 (en) 2010-11-29 2015-08-20 Ge Healthcare Limited Preparation of pet precursor
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
US9061977B2 (en) 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
BR112013020627B1 (pt) * 2011-03-08 2019-12-03 Ge Healthcare Ltd processo para preparação de um composto
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
CA3055417A1 (en) * 2017-03-07 2018-09-13 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeling precursor compound and method for producing radioactive fluorine-labeled compound using same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
JP2004056725A (ja) * 2002-07-24 2004-02-19 Matsushita Electric Works Ltd 設備管理サーバ、設備監視制御システムおよび設備管理サーバ用プログラム
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
GB0422004D0 (en) 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
ATE506347T1 (de) * 2005-05-23 2011-05-15 Nihon Mediphysics Co Ltd Neue organische verbindung und verfahren zur herstellung einer mit radioaktivem halogen markierten organischen verbindung unter anwendung davon
JP5349960B2 (ja) 2005-06-23 2013-11-20 エモリー ユニバーシティー 腫瘍画像化のためのアミノ酸類似体の立体選択的合成
KR101608755B1 (ko) 2005-11-29 2016-04-04 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물
RU2434846C2 (ru) 2006-05-11 2011-11-27 Нихон Меди-Физикс Ко., Лтд. Способ получения радиоактивного фтор-меченного органического соединения

Also Published As

Publication number Publication date
TW200826965A (en) 2008-07-01
US8563771B2 (en) 2013-10-22
JPWO2008078589A1 (ja) 2010-04-22
NO343437B1 (no) 2019-03-11
CA2672914C (en) 2014-02-04
EP2128130B1 (en) 2018-10-10
EP3530648B1 (en) 2023-11-08
NO345488B1 (no) 2021-03-01
TWI402079B (zh) 2013-07-21
AU2007337481B2 (en) 2012-02-09
EP2128130A1 (en) 2009-12-02
US20100016626A1 (en) 2010-01-21
KR20090093969A (ko) 2009-09-02
CN101573330B (zh) 2015-04-08
RU2009128664A (ru) 2011-02-10
NO20092389L (no) 2009-09-21
KR101408727B1 (ko) 2014-06-17
BRPI0720465B1 (pt) 2018-11-27
RU2466984C2 (ru) 2012-11-20
JP5518337B2 (ja) 2014-06-11
CN101573330A (zh) 2009-11-04
CA2672914A1 (en) 2008-07-03
NO20181508A1 (no) 2009-09-21
AU2007337481A1 (en) 2008-07-03
HK1135372A1 (en) 2010-06-04
EP3530648A1 (en) 2019-08-28
BRPI0720465A2 (pt) 2014-01-14
EP2128130A4 (en) 2012-01-04
WO2008078589A1 (ja) 2008-07-03

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO