TWI372761B - Method for purification of adefovir dipivoxil - Google Patents

Method for purification of adefovir dipivoxil

Info

Publication number
TWI372761B
TWI372761B TW098130789A TW98130789A TWI372761B TW I372761 B TWI372761 B TW I372761B TW 098130789 A TW098130789 A TW 098130789A TW 98130789 A TW98130789 A TW 98130789A TW I372761 B TWI372761 B TW I372761B
Authority
TW
Taiwan
Prior art keywords
purification
adefovir dipivoxil
dipivoxil
adefovir
Prior art date
Application number
TW098130789A
Other languages
English (en)
Other versions
TW201016713A (en
Inventor
Il-Hwan Cho
Myeong-Sik Yoon
Kwang-Do Choi
Yong-Tack Lee
Si-Beum Lee
Seong-Cheol Bang
Min-Kyoung Lee
Da-Won Oh
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of TW201016713A publication Critical patent/TW201016713A/zh
Application granted granted Critical
Publication of TWI372761B publication Critical patent/TWI372761B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW098130789A 2008-09-11 2009-09-11 Method for purification of adefovir dipivoxil TWI372761B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080089907 2008-09-11
KR1020090001395A KR20100031045A (ko) 2008-09-11 2009-01-08 아데포비어 디피복실의 정제방법

Publications (2)

Publication Number Publication Date
TW201016713A TW201016713A (en) 2010-05-01
TWI372761B true TWI372761B (en) 2012-09-21

Family

ID=42180843

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098130789A TWI372761B (en) 2008-09-11 2009-09-11 Method for purification of adefovir dipivoxil

Country Status (7)

Country Link
US (1) US20110207928A1 (zh)
EP (1) EP2327708A4 (zh)
JP (2) JP5390617B2 (zh)
KR (2) KR20100031045A (zh)
CN (1) CN102143967B (zh)
TW (1) TWI372761B (zh)
WO (1) WO2010030132A2 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI609745B (zh) * 2015-07-02 2018-01-01 嘉新精密有限公司 側向夾持的彈性定位塊結構

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR101247653B1 (ko) * 2010-11-08 2013-04-01 (주) 성운파마코피아 아데포비어 디피복실 제조방법
US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
CN103880884A (zh) * 2014-03-21 2014-06-25 浙江苏泊尔制药有限公司 一种高纯度富马酸泰诺福韦酯的制备方法
CN105294762A (zh) * 2015-11-13 2016-02-03 中国药科大学 阿德福韦酯杂质的制备方法
CN106167503B (zh) * 2016-07-07 2018-06-22 福建广生堂药业股份有限公司 一种阿德福韦酯羟甲基杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE167679T1 (de) * 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
ZA986614B (en) 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
TR200000224T2 (tr) 1997-07-25 2000-07-21 Gilead Sciences, Inc. Nükleotid analog kompozisyonlar.
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
CN1935818B (zh) * 2006-09-22 2011-11-09 闫敬武 阿德福韦酯新晶态、晶态组合物、制备方法及应用
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
CN102149715A (zh) * 2008-09-17 2011-08-10 Cj第一制糖株式会社 肝适能的稳定化固态分散物及其制备方法
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI609745B (zh) * 2015-07-02 2018-01-01 嘉新精密有限公司 側向夾持的彈性定位塊結構

Also Published As

Publication number Publication date
CN102143967B (zh) 2015-02-04
JP5390617B2 (ja) 2014-01-15
TW201016713A (en) 2010-05-01
KR100970434B1 (ko) 2010-07-15
EP2327708A2 (en) 2011-06-01
WO2010030132A3 (ko) 2010-06-10
WO2010030132A2 (ko) 2010-03-18
JP2012512137A (ja) 2012-05-31
US20110207928A1 (en) 2011-08-25
JP2014114271A (ja) 2014-06-26
WO2010030132A9 (ko) 2010-08-05
KR20100031045A (ko) 2010-03-19
EP2327708A4 (en) 2011-11-30
KR20100031085A (ko) 2010-03-19
CN102143967A (zh) 2011-08-03

Similar Documents

Publication Publication Date Title
TWI372761B (en) Method for purification of adefovir dipivoxil
EP2128151A4 (en) CYCLIC ESTER PURIFICATION METHOD
EP2266067A4 (en) METHOD OF PATIENT GENOTYPING
EP2363467A4 (en) PROCESS FOR INHIBITING MICRO-RNA FUNCTION
EP2246353A4 (en) PROCESS FOR PREPARING AN ADENINE COMPOUND
EP2471740A4 (en) PROCESS FOR THE PURIFICATION OF CHLOROSILANE
PL2297169T3 (pl) Sposób wytwarzania kwasu aminoalkilenofosfonowego
EP2281567A4 (en) INHIBITOR OF INCREASED PHOSPHORUS RATE IN BLOOD
EP2357164A4 (en) PROCESS FOR THE PRODUCTION OF A -SUBSTITUTED ESTER
IL200945A0 (en) Method for producing phosphorus-containing ?? -keto acid
IL219348A (en) A method for cleaning colistin
HK1163664A1 (zh) 製備活化酯的方法
GB0816242D0 (en) Method of purifying protien complexes
EP2266943A4 (en) PROCESS FOR PRODUCING 2-ALKYL-2-CYCLOALCENE-1-ONE
ZA201202611B (en) Process for the preparetion of fosamprenavir calcium
ZA201003816B (en) Method for production of calcium compounds
EP2465819A4 (en) PROCESS FOR THE PURIFICATION OF CHLOROSILANES
EP2330107A4 (en) PROCESS FOR THE IMPROVED PRODUCTION OF ADEFOVIR DIPIVOXIL
GB2459738B (en) Method of purification
EP2211616A4 (en) PROCESS FOR PREPARING IMIDAZOAZEPINONE COMPOUNDS
HK1162856A1 (en) Method of preparing deoxyribofuranose compounds
IL208294A0 (en) Process for purifying an ??-keto ester
EP2218492A4 (en) PROCESS FOR REMOVING CIO3F
EP2427776A4 (en) METHOD OF DETERMINING SYSTEM P OF BLOOD GROUPS
EP2252149A4 (en) PROCESS FOR PREPARING FENTANYLE

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees