EA201000147A1 - Способ выделения и очистки монтелукаста - Google Patents
Способ выделения и очистки монтелукастаInfo
- Publication number
- EA201000147A1 EA201000147A1 EA201000147A EA201000147A EA201000147A1 EA 201000147 A1 EA201000147 A1 EA 201000147A1 EA 201000147 A EA201000147 A EA 201000147A EA 201000147 A EA201000147 A EA 201000147A EA 201000147 A1 EA201000147 A1 EA 201000147A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- montelukast
- salts
- formula
- primary amines
- isolation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Способ выделения монтелукаста формулы (I) из реакционных смесей, включающий преобразование сырого вещества в хорошо кристаллизующиеся соли с первичными аминами в среде по меньшей мере с одним органическим растворителем и ацетонитрилом с последующей перекристаллизацией этих солей с одновременным удалением химических примесей и использование химически чистых солей монтелукаста с первичными аминами для прямого преобразования в фармацевтически пригодную аморфную форму монтелукаста натрия формулы (II)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20070455A CZ302518B6 (cs) | 2007-07-09 | 2007-07-09 | Zpusob izolace a cištení montelukastu |
PCT/CZ2008/000081 WO2009006861A2 (en) | 2007-07-09 | 2008-07-08 | A method for isolation and purification of montelukast |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201000147A1 true EA201000147A1 (ru) | 2010-06-30 |
EA018481B1 EA018481B1 (ru) | 2013-08-30 |
Family
ID=40229131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000147A EA018481B1 (ru) | 2007-07-09 | 2008-07-08 | Способ выделения аморфной соли монтелукаста натрия |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100267958A1 (ru) |
EP (1) | EP2173718A2 (ru) |
CZ (1) | CZ302518B6 (ru) |
EA (1) | EA018481B1 (ru) |
UA (1) | UA100125C2 (ru) |
WO (1) | WO2009006861A2 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2287154A1 (en) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
WO2012077133A1 (en) * | 2010-12-07 | 2012-06-14 | Ind-Swift Laboratories Limited | Processes for preparation of montelukast sodium and purification of diol intermediate |
CN102060762B (zh) * | 2011-01-28 | 2013-05-29 | 海南美大制药有限公司 | 孟鲁司特化合物及其新制法 |
JP6162004B2 (ja) * | 2013-09-10 | 2017-07-12 | 株式会社トクヤマ | モンテルカストナトリウム中間体の分析方法 |
JP6173864B2 (ja) * | 2013-10-01 | 2017-08-02 | 株式会社トクヤマ | モンテルカストナトリウムのアモルファスを製造する方法 |
CN104119270A (zh) * | 2014-08-12 | 2014-10-29 | 牡丹江恒远药业有限公司 | 一种孟鲁司特钠的制备方法 |
CN105924392B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种孟鲁司特钠制备方法 |
CN105585524B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种由孟鲁司特酸制备孟鲁司特钠的方法 |
CN109503476A (zh) * | 2018-12-26 | 2019-03-22 | 哈尔滨珍宝制药有限公司 | 一种孟鲁司特钠的合成工艺 |
CN112028824B (zh) * | 2020-09-30 | 2021-12-14 | 山东安信制药有限公司 | 一种孟鲁司特钠的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
US5937536A (en) * | 1997-10-06 | 1999-08-17 | Pharmacopeia, Inc. | Rapid drying oven for providing rapid drying of multiple samples |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
CA2528228C (en) * | 2003-06-06 | 2011-09-20 | Morepen Laboratories Limited | A method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
WO2005074935A1 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
DE602005015174D1 (de) * | 2004-04-21 | 2009-08-13 | Teva Pharma | Verfahren zur herstellung von montelukast-natrium |
PL205637B1 (pl) * | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
US7812168B2 (en) * | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
US20110092708A1 (en) * | 2006-08-04 | 2011-04-21 | Seeta Ramanjaneyulu Gorantla | Process for the preparation of montelukast and its salts thereof |
WO2008062478A2 (en) * | 2006-11-20 | 2008-05-29 | Manne Satyanarayana Reddy | Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts |
-
2007
- 2007-07-09 CZ CZ20070455A patent/CZ302518B6/cs not_active IP Right Cessation
-
2008
- 2008-07-08 EA EA201000147A patent/EA018481B1/ru not_active IP Right Cessation
- 2008-07-08 UA UAA201001362A patent/UA100125C2/ru unknown
- 2008-07-08 EP EP08784159A patent/EP2173718A2/en not_active Withdrawn
- 2008-07-08 WO PCT/CZ2008/000081 patent/WO2009006861A2/en active Application Filing
- 2008-07-08 US US12/667,147 patent/US20100267958A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CZ302518B6 (cs) | 2011-06-29 |
US20100267958A1 (en) | 2010-10-21 |
CZ2007455A3 (cs) | 2009-03-04 |
WO2009006861A2 (en) | 2009-01-15 |
EP2173718A2 (en) | 2010-04-14 |
EA018481B1 (ru) | 2013-08-30 |
UA100125C2 (ru) | 2012-11-26 |
WO2009006861A3 (en) | 2009-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |