NO20025054L - Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre - Google Patents

Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Info

Publication number
NO20025054L
NO20025054L NO20025054A NO20025054A NO20025054L NO 20025054 L NO20025054 L NO 20025054L NO 20025054 A NO20025054 A NO 20025054A NO 20025054 A NO20025054 A NO 20025054A NO 20025054 L NO20025054 L NO 20025054L
Authority
NO
Norway
Prior art keywords
alpha
beta
preparation
androst
dien
Prior art date
Application number
NO20025054A
Other languages
English (en)
Other versions
NO324836B1 (no
NO20025054D0 (no
Inventor
Frederick David Albinson
Steven John Coote
John Malcolm Robinson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20025054D0 publication Critical patent/NO20025054D0/no
Publication of NO20025054L publication Critical patent/NO20025054L/no
Publication of NO324836B1 publication Critical patent/NO324836B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO20025054A 2000-07-21 2002-10-21 Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre NO324836B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0017988.7A GB0017988D0 (en) 2000-07-21 2000-07-21 Novel process
PCT/GB2001/003289 WO2002008243A1 (en) 2000-07-21 2001-07-20 Oxidation process for preparing the intermediate 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid

Publications (3)

Publication Number Publication Date
NO20025054D0 NO20025054D0 (no) 2002-10-21
NO20025054L true NO20025054L (no) 2002-11-05
NO324836B1 NO324836B1 (no) 2007-12-17

Family

ID=9896132

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025054A NO324836B1 (no) 2000-07-21 2002-10-21 Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Country Status (26)

Country Link
US (1) US20040043974A1 (no)
EP (1) EP1301526B1 (no)
JP (1) JP2004504403A (no)
KR (1) KR100787293B1 (no)
CN (1) CN1315864C (no)
AT (1) ATE398628T1 (no)
AU (2) AU7090601A (no)
BR (1) BR0110430A (no)
CA (1) CA2406963A1 (no)
CY (1) CY1108553T1 (no)
CZ (1) CZ302592B6 (no)
DE (1) DE60134472D1 (no)
DK (1) DK1301526T3 (no)
ES (1) ES2307628T3 (no)
GB (1) GB0017988D0 (no)
HK (1) HK1056179B (no)
HU (1) HUP0301108A3 (no)
IL (2) IL152348A0 (no)
MX (1) MXPA02010967A (no)
NO (1) NO324836B1 (no)
NZ (1) NZ522083A (no)
PL (1) PL206652B1 (no)
PT (1) PT1301526E (no)
SI (1) SI1301526T1 (no)
WO (1) WO2002008243A1 (no)
ZA (1) ZA200208372B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en) 2006-06-16 2006-07-26 Glaxo Group Ltd Novel process
NO331891B1 (no) 2007-03-20 2012-04-30 Clavis Pharma Asa Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) * 2010-06-01 2013-01-29 Hovione Farmaciencia S A Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
JP2013536835A (ja) 2010-09-01 2013-09-26 カディラ・ヘルスケア・リミテッド プロピオン酸／フロ酸フルチカゾンを調製するための方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
CY1291A (en) * 1980-02-15 1985-10-18 Glaxo Group Ltd Androstane 17 beta carbothioates
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
BR9612309A (pt) * 1995-12-29 1999-07-13 Glaxo Group Ltd Composto uso de um composto composição farmacêutica formulação farmacêutica de aerossol combinação e processos para o tratamento de um indivíduo humano ou animal com uma condição anti-inflamatória e/ou alérgica e para a preparação de um composto
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
CZ20023320A3 (cs) * 2000-04-04 2003-04-16 Celanese International Corporation Prostředek pro tvorbu povlaku
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions

Also Published As

Publication number Publication date
MXPA02010967A (es) 2003-03-27
IL152348A0 (en) 2003-05-29
HK1056179B (zh) 2009-07-17
PT1301526E (pt) 2008-09-09
US20040043974A1 (en) 2004-03-04
NZ522083A (en) 2004-06-25
BR0110430A (pt) 2003-07-08
KR100787293B1 (ko) 2007-12-20
PL359462A1 (en) 2004-08-23
GB0017988D0 (en) 2000-09-13
HUP0301108A3 (en) 2008-04-28
CA2406963A1 (en) 2002-01-31
CZ302592B6 (cs) 2011-07-27
CN1437610A (zh) 2003-08-20
DK1301526T3 (da) 2008-10-06
PL206652B1 (pl) 2010-09-30
ES2307628T3 (es) 2008-12-01
WO2002008243A1 (en) 2002-01-31
SI1301526T1 (sl) 2008-10-31
DE60134472D1 (de) 2008-07-31
ZA200208372B (en) 2004-02-11
EP1301526A1 (en) 2003-04-16
IL152348A (en) 2008-08-07
AU2001270906B2 (en) 2005-10-13
CY1108553T1 (el) 2014-04-09
NO324836B1 (no) 2007-12-17
ATE398628T1 (de) 2008-07-15
AU7090601A (en) 2002-02-05
NO20025054D0 (no) 2002-10-21
EP1301526B1 (en) 2008-06-18
HK1056179A1 (en) 2004-02-06
KR20030028736A (ko) 2003-04-10
CZ20023472A3 (cs) 2003-04-16
CN1315864C (zh) 2007-05-16
JP2004504403A (ja) 2004-02-12
HUP0301108A2 (hu) 2003-08-28

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