HUP0301108A2 - Oxidációs eljárás a 6alfa, 9alfa-difluor-11béta, 17alfa-dihidroxi-16alfa-metil-androszt-1,4-dien-3-on-17béta-karbonsav intermedier előállítására - Google Patents

Oxidációs eljárás a 6alfa, 9alfa-difluor-11béta, 17alfa-dihidroxi-16alfa-metil-androszt-1,4-dien-3-on-17béta-karbonsav intermedier előállítására

Info

Publication number
HUP0301108A2
HUP0301108A2 HU0301108A HUP0301108A HUP0301108A2 HU P0301108 A2 HUP0301108 A2 HU P0301108A2 HU 0301108 A HU0301108 A HU 0301108A HU P0301108 A HUP0301108 A HU P0301108A HU P0301108 A2 HUP0301108 A2 HU P0301108A2
Authority
HU
Hungary
Prior art keywords
oxidation process
9alpha
6alpha
16alpha
11beta
Prior art date
Application number
HU0301108A
Other languages
English (en)
Inventor
Frederick David Albinson
Steven John Coote
John Malcolm Robinson
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HUP0301108A2 publication Critical patent/HUP0301108A2/hu
Publication of HUP0301108A3 publication Critical patent/HUP0301108A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány tárgyát képezi új oxidációs eljárás egy ismert, agyulladásellenes szteroidok (pl. flutikazonpropionát) előállításábanalkalmazott (I) általános képletű intermedier előállítására. Atalálmány szerinti eljárást úgy végzik, hogy az (a) lépésben oxidálnakegy (II) általános képletű vegyületet tartalmazó oldatot, ahol azoldatot víz és THF elegyeként képezik. Ó
HU0301108A 2000-07-21 2001-07-20 Oxidation process for preparing the intermediate 6alpha, 9alpha HUP0301108A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0017988.7A GB0017988D0 (en) 2000-07-21 2000-07-21 Novel process
PCT/GB2001/003289 WO2002008243A1 (en) 2000-07-21 2001-07-20 Oxidation process for preparing the intermediate 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid

Publications (2)

Publication Number Publication Date
HUP0301108A2 true HUP0301108A2 (hu) 2003-08-28
HUP0301108A3 HUP0301108A3 (en) 2008-04-28

Family

ID=9896132

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301108A HUP0301108A3 (en) 2000-07-21 2001-07-20 Oxidation process for preparing the intermediate 6alpha, 9alpha

Country Status (26)

Country Link
US (1) US20040043974A1 (hu)
EP (1) EP1301526B1 (hu)
JP (1) JP2004504403A (hu)
KR (1) KR100787293B1 (hu)
CN (1) CN1315864C (hu)
AT (1) ATE398628T1 (hu)
AU (2) AU2001270906B2 (hu)
BR (1) BR0110430A (hu)
CA (1) CA2406963A1 (hu)
CY (1) CY1108553T1 (hu)
CZ (1) CZ302592B6 (hu)
DE (1) DE60134472D1 (hu)
DK (1) DK1301526T3 (hu)
ES (1) ES2307628T3 (hu)
GB (1) GB0017988D0 (hu)
HK (1) HK1056179B (hu)
HU (1) HUP0301108A3 (hu)
IL (2) IL152348A0 (hu)
MX (1) MXPA02010967A (hu)
NO (1) NO324836B1 (hu)
NZ (1) NZ522083A (hu)
PL (1) PL206652B1 (hu)
PT (1) PT1301526E (hu)
SI (1) SI1301526T1 (hu)
WO (1) WO2002008243A1 (hu)
ZA (1) ZA200208372B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
EP1611149A1 (en) * 2003-04-04 2006-01-04 Alpharma APS Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en) 2006-06-16 2006-07-26 Glaxo Group Ltd Novel process
NO331891B1 (no) * 2007-03-20 2012-04-30 Clavis Pharma Asa Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) * 2010-06-01 2013-01-29 Hovione Farmaciencia S A Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
US8841442B2 (en) 2010-09-01 2014-09-23 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
GB2088877B (en) * 1980-02-15 1984-07-04 Glaxo Group Ltd Androstane 17 carbothioates
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
CA2241728A1 (en) * 1995-12-29 1997-07-10 Panayiotis Alexandrou Procopiou Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
DE60028618T2 (de) * 2000-04-04 2007-06-06 Celanese International Corp., Dallas Tintenaufnehmende zusammensetzung, die polyvinylalkohol mit gepfropften amingruppen enthaelt
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions

Also Published As

Publication number Publication date
WO2002008243A1 (en) 2002-01-31
AU7090601A (en) 2002-02-05
SI1301526T1 (sl) 2008-10-31
HK1056179A1 (en) 2004-02-06
GB0017988D0 (en) 2000-09-13
MXPA02010967A (es) 2003-03-27
CZ302592B6 (cs) 2011-07-27
KR100787293B1 (ko) 2007-12-20
BR0110430A (pt) 2003-07-08
CN1315864C (zh) 2007-05-16
JP2004504403A (ja) 2004-02-12
ZA200208372B (en) 2004-02-11
HUP0301108A3 (en) 2008-04-28
PT1301526E (pt) 2008-09-09
IL152348A0 (en) 2003-05-29
CA2406963A1 (en) 2002-01-31
PL359462A1 (en) 2004-08-23
CY1108553T1 (el) 2014-04-09
CN1437610A (zh) 2003-08-20
DE60134472D1 (de) 2008-07-31
AU2001270906B2 (en) 2005-10-13
NO324836B1 (no) 2007-12-17
DK1301526T3 (da) 2008-10-06
ATE398628T1 (de) 2008-07-15
NO20025054L (no) 2002-11-05
ES2307628T3 (es) 2008-12-01
HK1056179B (zh) 2009-07-17
EP1301526B1 (en) 2008-06-18
PL206652B1 (pl) 2010-09-30
NZ522083A (en) 2004-06-25
NO20025054D0 (no) 2002-10-21
KR20030028736A (ko) 2003-04-10
EP1301526A1 (en) 2003-04-16
CZ20023472A3 (cs) 2003-04-16
IL152348A (en) 2008-08-07
US20040043974A1 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
HUP0301108A2 (hu) Oxidációs eljárás a 6alfa, 9alfa-difluor-11béta, 17alfa-dihidroxi-16alfa-metil-androszt-1,4-dien-3-on-17béta-karbonsav intermedier előállítására
ATE461934T1 (de) Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-car onsäure -lacton und schlüsselzwischenprodukte für dieses verfahren
ATE246180T1 (de) Benzofuranon-derivate und verfahren zu ihrer herstellung
NO20023276L (no) Fremgangsmåter fremstilling av betulinsyre
DE60322852D1 (de) Verfahren zur herstellung von eplerenon
HUP9903747A2 (hu) Új eljárás mometazon-furoát előállítására
HUP9902040A2 (hu) Új eljárás 4-fenil-1,2,3,6-tetrahidro-piridin-származékok előállítására és az alkalmazott köztitermékek
ATE276660T1 (de) Verfahren zur herstellung eines bioziden konzentrates
ATE302749T1 (de) Verfahren zur herstellung von 5-aminosalicylsäure
DE50209490D1 (de) Verfahren zur herstellung von zolpidem
EE200300124A (et) 17alfa-fluoroalküülsteroidid, nende valmistamismeetod ja neid ühendeid sisaldavad farmatseutilised kompositsioonid
ATE277071T1 (de) Durch 11-beta-aryl-17,17-spirothiolan substituierte steroide
NO20054636L (no) Fremgangsmate for fremstilling av steroidale karbotiosyrederivater og -intermediater
MY140446A (en) Process for the production of 6.alpha.,9.alpha-difluoro-17.alpha.-(1-oxo-propoxy-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4-diene-17.beta.-carbothioic acid
HUP0204456A2 (hu) Eljárás (S)-2-acetil-tio-3-fenil-propionsav előállítására
DE69915965D1 (de) Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid
DE60102547D1 (de) Verfahren zur Herstellung von Anthrachinon-2-Carbonsäure durch Oxidation von Ethyl-2-anthrachinon mit Salpetersäure
MXPA04002758A (es) Transacetalizacion estereoselectiva de acetonido c-22 esteroidal.
UA30788A (uk) Спосіб одержання графіту, що термічно розширюється
WO2003029267A3 (es) PROCEDIMIENTO PARA LA OBTENCION DE 17β-(SUSTITUIDO)-3-OXO-Δ1,2-4-AZAESTEROIDES E INTERMEDIOS
DK1163257T3 (da) Fremgangsmåde til fremstilling af 4,4-dimethyl-3beta-hydroxypregna-8,14-dien-21-carboxylsyreestere og mellemprodukter i fremgangsmåden
JPH08176187A (ja) １４α−ヒドロキシ−４−アンドロステン−３，６，１７−トリオンの新規製造法
HUP0302407A2 (hu) Új eljárás (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására és az eljárás intermedierjei

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished